smooth endoplasmic reticulum Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. (Gene Ontology, GO_0005790)
Similar Terms
Downloads & Tools


18 proteins localized to the smooth endoplasmic reticulum cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GBA2 glucosidase, beta (bile acid) 2 0.663342
PSEN1 presenilin 1 0.663342
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.237908
RYR1 ryanodine receptor 1 (skeletal) 0.237908
SLMAP sarcolemma associated protein 0.237908
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.237908
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.237908
STX17 syntaxin 17 0.237908
TH tyrosine hydroxylase 0.237908
RYR2 ryanodine receptor 2 (cardiac) 0.03318
PLCB4 phospholipase C, beta 4 0.03318
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.03318
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.03318
TTYH1 tweety family member 1 0.03318
JPH4 junctophilin 4 0.03318
MYO1D myosin ID 0.03318
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.03318
GABARAP GABA(A) receptor-associated protein 0.03318