small thymus Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced size of the thymus (Mammalian Phenotype Ontology, MP_0000706)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000706
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Genes

206 gene mutations causing the small thymus phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
AFF1 AF4/FMR2 family, member 1
AIRE autoimmune regulator
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP1 Rho GTPase activating protein 1
ARHGAP5 Rho GTPase activating protein 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAG4 BCL2-associated athanogene 4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACYBP calcyclin binding protein
CARM1 coactivator-associated arginine methyltransferase 1
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCNB2 cyclin B2
CCND3 cyclin D3
CD247 CD247 molecule
CD2AP CD2-associated protein
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CDK6 cyclin-dependent kinase 6
CHD7 chromodomain helicase DNA binding protein 7
COL10A1 collagen, type X, alpha 1
CRIP3 cysteine-rich protein 3
CTC1 CTS telomere maintenance complex component 1
CTSD cathepsin D
CTSV cathepsin V
CUX1 cut-like homeobox 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYCS cytochrome c, somatic
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYS1 cystin 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAD1 defender against cell death 1
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DFNB31 deafness, autosomal recessive 31
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNASE2 deoxyribonuclease II, lysosomal
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F4 E2F transcription factor 4, p107/p130-binding
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FES FES proto-oncogene, tyrosine kinase
FGF10 fibroblast growth factor 10
FGF23 fibroblast growth factor 23
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUS FUS RNA binding protein
FZD9 frizzled class receptor 9
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLRA1 glycine receptor, alpha 1
GNAS GNAS complex locus
HAX1 HCLS1 associated protein X-1
HELLS helicase, lymphoid-specific
HOXA1 homeobox A1
HOXB9 homeobox B9
HR hair growth associated
HTRA2 HtrA serine peptidase 2
HYDIN HYDIN, axonemal central pair apparatus protein
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0101 KIAA0101
KIFAP3 kinesin-associated protein 3
KITLG KIT ligand
KL klotho
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LRP2 low density lipoprotein receptor-related protein 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
NBN nibrin
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCOR1 nuclear receptor corepressor 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NLK nemo-like kinase
NOTCH3 notch 3
PARL presenilin associated, rhomboid-like
PCSK5 proprotein convertase subtilisin/kexin type 5
PFDN1 prefoldin subunit 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIKFYVE phosphoinositide kinase, FYVE finger containing
PKNOX1 PBX/knotted 1 homeobox 1
PLXND1 plexin D1
PNP purine nucleoside phosphorylase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RECQL4 RecQ protein-like 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RIPPLY3 ripply transcriptional repressor 3
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPL27A ribosomal protein L27a
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
SATB1 SATB homeobox 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPL1 sphingosine-1-phosphate lyase 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC46A2 solute carrier family 46, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SP3 Sp3 transcription factor
SP4 Sp4 transcription factor
SPI1 Spi-1 proto-oncogene
STK36 serine/threonine kinase 36
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACC3 transforming, acidic coiled-coil containing protein 3
TBX1 T-box 1
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDP2 tyrosyl-DNA phosphodiesterase 2
TNF tumor necrosis factor
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
VAV1 vav 1 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
WWOX WW domain containing oxidoreductase
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMPSTE24 zinc metallopeptidase STE24