sleep disturbance Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness. (Human Phenotype Ontology, HP_0002360)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002360
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Genes

266 genes associated with the sleep disturbance phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
C6ORF10 chromosome 6 open reading frame 10 1.49995
MRPL24 mitochondrial ribosomal protein L24 1.44713
CENPC centromere protein C 1.40163
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.39826
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.33168
JAKMIP2 janus kinase and microtubule interacting protein 2 1.30633
NOTCH4 notch 4 1.29906
FAM171A1 family with sequence similarity 171, member A1 1.29629
CCDC68 coiled-coil domain containing 68 1.29185
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.29087
OXR1 oxidation resistance 1 1.28419
NPFFR2 neuropeptide FF receptor 2 1.27943
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.27585
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.25916
POLI polymerase (DNA directed) iota 1.25876
GPC5 glypican 5 1.25834
JPH1 junctophilin 1 1.25121
CTNND2 catenin (cadherin-associated protein), delta 2 1.25109
CSMD3 CUB and Sushi multiple domains 3 1.23966
PHF20 PHD finger protein 20 1.22888
TRIM9 tripartite motif containing 9 1.22854
CATSPER4 cation channel, sperm associated 4 1.2266
ACSS1 acyl-CoA synthetase short-chain family member 1 1.22108
RYR2 ryanodine receptor 2 (cardiac) 1.21909
ELMO1 engulfment and cell motility 1 1.20822
NOX4 NADPH oxidase 4 1.19406
MCC mutated in colorectal cancers 1.19381
LOC100507377 uncharacterized LOC100507377 1.19021
ZYG11B zyg-11 family member B, cell cycle regulator 1.18101
TMEM108 transmembrane protein 108 1.17899
FOLR1 folate receptor 1 (adult) 1.17818
DNAH8 dynein, axonemal, heavy chain 8 1.17786
WDR48 WD repeat domain 48 1.17517
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.17441
DPYD dihydropyrimidine dehydrogenase 1.16798
VAT1L vesicle amine transport 1-like 1.16104
NKAIN3 Na+/K+ transporting ATPase interacting 3 1.15722
SDK1 sidekick cell adhesion molecule 1 1.15324
PRCP prolylcarboxypeptidase (angiotensinase C) 1.14686
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.14625
SUN5 Sad1 and UNC84 domain containing 5 1.14219
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 1.14192
C8ORF34 chromosome 8 open reading frame 34 1.12942
RIT2 Ras-like without CAAX 2 1.12864
LYRM4 LYR motif containing 4 1.12785
TIAM1 T-cell lymphoma invasion and metastasis 1 1.12774
GRM8 glutamate receptor, metabotropic 8 1.1261
KIAA0922 KIAA0922 1.12208
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 1.12139
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.12053
PALLD palladin, cytoskeletal associated protein 1.11842
FHOD3 formin homology 2 domain containing 3 1.11675
FSTL5 follistatin-like 5 1.11101
TF transferrin 1.10948
TCERG1 transcription elongation regulator 1 1.10629
ATG5 autophagy related 5 1.10629
AGTR1 angiotensin II receptor, type 1 1.10536
ANO3 anoctamin 3 1.10285
PDE4B phosphodiesterase 4B, cAMP-specific 1.10162
GRM5 glutamate receptor, metabotropic 5 1.10035
NRXN1 neurexin 1 1.09306
BCR breakpoint cluster region 1.09212
CA10 carbonic anhydrase X 1.08843
NKAIN2 Na+/K+ transporting ATPase interacting 2 1.08695
GRID1 glutamate receptor, ionotropic, delta 1 1.08103
FOXP2 forkhead box P2 1.08098
ASTN1 astrotactin 1 1.07962
RBMS3 RNA binding motif, single stranded interacting protein 3 1.07265
ATF6 activating transcription factor 6 1.07237
UNC5D unc-5 homolog D (C. elegans) 1.07191
VAV1 vav 1 guanine nucleotide exchange factor 1.07005
UST uronyl-2-sulfotransferase 1.0674
CTNNA2 catenin (cadherin-associated protein), alpha 2 1.06569
KLF12 Kruppel-like factor 12 1.06093
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 1.05998
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 1.05838
RNGTT RNA guanylyltransferase and 5'-phosphatase 1.05477
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 1.05093
RAD50 RAD50 homolog (S. cerevisiae) 1.04962
VAV2 vav 2 guanine nucleotide exchange factor 1.04036
PPARA peroxisome proliferator-activated receptor alpha 1.039
SFRP1 secreted frizzled-related protein 1 1.03681
SERAC1 serine active site containing 1 1.03621
NT5DC1 5'-nucleotidase domain containing 1 1.0342
LOC339166 uncharacterized LOC339166 1.02541
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.02374
LINC00536 long intergenic non-protein coding RNA 536 1.02361
BTNL2 butyrophilin-like 2 1.02154
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 1.02086
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 1.01781
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 1.00953
GLIS3 GLIS family zinc finger 3 1.00733
GAREM GRB2 associated, regulator of MAPK1 1.00386
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 1.00226
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.992637
NOL4 nucleolar protein 4 0.991905
ANTXR2 anthrax toxin receptor 2 0.990459
MRAS muscle RAS oncogene homolog 0.985145
HINT3 histidine triad nucleotide binding protein 3 0.980955
DCDC2C doublecortin domain containing 2C 0.979364
DHODH dihydroorotate dehydrogenase (quinone) 0.97911
DCHS1 dachsous cadherin-related 1 0.974784
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.969683
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.969142
DAP3 death associated protein 3 0.963829
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.961507
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.960889
FRMPD2 FERM and PDZ domain containing 2 0.960091
CDK8 cyclin-dependent kinase 8 0.959896
BLMH bleomycin hydrolase 0.95486
CHODL chondrolectin 0.952642
CEP112 centrosomal protein 112kDa 0.951136
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.942765
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.942765
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 0.940185
STK32A serine/threonine kinase 32A 0.940153
ADAMTSL3 ADAMTS-like 3 0.935276
FGF12 fibroblast growth factor 12 0.919744
UBIAD1 UbiA prenyltransferase domain containing 1 0.911279
WWOX WW domain containing oxidoreductase 0.903602
EBF3 early B-cell factor 3 0.899912
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.895338
GRID2 glutamate receptor, ionotropic, delta 2 0.859243
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.856413
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.848993
CORO2A coronin, actin binding protein, 2A 0.834343
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.82221
CCDC184 coiled-coil domain containing 184 0.804323
NDRG1 N-myc downstream regulated 1 0.785384
NTN4 netrin 4 0.781779
FZD2 frizzled class receptor 2 0.776085
TBC1D2 TBC1 domain family, member 2 0.771265
AMPH amphiphysin 0.738585
PARK2 parkin RBR E3 ubiquitin protein ligase 0.730636
NWD2 NACHT and WD repeat domain containing 2 0.724474
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.712536
SLC35F3 solute carrier family 35, member F3 0.680272
RSRC1 arginine/serine-rich coiled-coil 1 0.678437
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.669923
OPCML opioid binding protein/cell adhesion molecule-like 0.63395
FHIT fragile histidine triad 0.570703
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.558232
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.522136
HLA-DRA major histocompatibility complex, class II, DR alpha 0.514669
EPB41 erythrocyte membrane protein band 4.1 0.511041
MYRIP myosin VIIA and Rab interacting protein 0.49076
HDAC9 histone deacetylase 9 0.488557
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.488464
LOC401324 uncharacterized LOC401324 0.477658
PARVA parvin, alpha 0.464962
GYLTL1B glycosyltransferase-like 1B 0.457491
GRK4 G protein-coupled receptor kinase 4 0.455306
EPHB1 EPH receptor B1 0.45248
TMEM165 transmembrane protein 165 0.445424
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.440297
NPAS2 neuronal PAS domain protein 2 0.43573
PDE4D phosphodiesterase 4D, cAMP-specific 0.431561
EDNRA endothelin receptor type A 0.431155
SHKBP1 SH3KBP1 binding protein 1 0.415375
ZNF365 zinc finger protein 365 0.409939
PDE7B phosphodiesterase 7B 0.407488
LOC100294145 uncharacterized LOC100294145 0.407202
BARX2 BARX homeobox 2 0.404893
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.404733
ITCH itchy E3 ubiquitin protein ligase 0.404129
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.40295
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.399615
HOXD-AS2 HOXD cluster antisense RNA 2 0.399387
ASIC2 acid sensing (proton gated) ion channel 2 0.399195
FAM179A family with sequence similarity 179, member A 0.397603
ING3 inhibitor of growth family, member 3 0.39588
PPAN peter pan homolog (Drosophila) 0.395511
HABP2 hyaluronan binding protein 2 0.393472
KALRN kalirin, RhoGEF kinase 0.393032
TENM2 teneurin transmembrane protein 2 0.392098
HLA-F-AS1 HLA-F antisense RNA 1 0.391321
EYA1 EYA transcriptional coactivator and phosphatase 1 0.390436
FGF10 fibroblast growth factor 10 0.38816
FRY furry homolog (Drosophila) 0.385307
AK5 adenylate kinase 5 0.385259
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.384911
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.384581
VTA1 vesicle (multivesicular body) trafficking 1 0.384122
NXPH1 neurexophilin 1 0.38297
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.382586
DENND3 DENN/MADD domain containing 3 0.381181
NCOA7 nuclear receptor coactivator 7 0.380936
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.380553
NUP37 nucleoporin 37kDa 0.380126
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.376825
TMEM132B transmembrane protein 132B 0.37523
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 0.373081
STIM1 stromal interaction molecule 1 0.372195
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.372031
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.370804
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.370368
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 0.368786
FXN frataxin 0.368354
AKAP6 A kinase (PRKA) anchor protein 6 0.366827
NFRKB nuclear factor related to kappaB binding protein 0.366756
AGBL1 ATP/GTP binding protein-like 1 0.366099
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.366036
SNX29 sorting nexin 29 0.365911
CHKB-CPT1B CHKB-CPT1B readthrough (NMD candidate) 0.364972
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.364961
FREM2 FRAS1 related extracellular matrix protein 2 0.364721
LRRC4C leucine rich repeat containing 4C 0.364701
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.364227
MAPT-AS1 MAPT antisense RNA 1 0.363942
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.363913
LRRN1 leucine rich repeat neuronal 1 0.361912
UBXN2B UBX domain protein 2B 0.361532
NCKAP5 NCK-associated protein 5 0.361532
LOC285692 uncharacterized LOC285692 0.34437
PRIMA1 proline rich membrane anchor 1 0.34437
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.338502
CPQ carboxypeptidase Q 0.338502
FAM169B family with sequence similarity 169, member B 0.338502
CFAP69 cilia and flagella associated protein 69 0.337265
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.336252
PTCD3 pentatricopeptide repeat domain 3 0.335058
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.33503
PLLP plasmolipin 0.33503
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.33503
LAMA1 laminin, alpha 1 0.333903
MTUS2 microtubule associated tumor suppressor candidate 2 0.332291
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.332125
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.331986
HAL histidine ammonia-lyase 0.330814
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.330164
MARK2 MAP/microtubule affinity-regulating kinase 2 0.32992
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.329902
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.329737
FGF14 fibroblast growth factor 14 0.328953
SNX6 sorting nexin 6 0.328739
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.326976
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.326275
RNF157 ring finger protein 157 0.324722
CCDC102B coiled-coil domain containing 102B 0.323291
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.321926
PLXNA2 plexin A2 0.320884
GPC6 glypican 6 0.318759
DOCK9 dedicator of cytokinesis 9 0.318539
NEB nebulin 0.31724
YAE1D1 Yae1 domain containing 1 0.316985
NPSR1 neuropeptide S receptor 1 0.316675
SPTBN1 spectrin, beta, non-erythrocytic 1 0.316493
PRSS56 protease, serine, 56 0.315683
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.315219
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 0.313876
PRUNE2 prune homolog 2 (Drosophila) 0.3119
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.311336
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.304658
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.304507
CALCR calcitonin receptor 0.301989
LENG8 leukocyte receptor cluster (LRC) member 8 0.30103
RYR3 ryanodine receptor 3 0.300713
TSHZ2 teashirt zinc finger homeobox 2 0.298881
SAMD3 sterile alpha motif domain containing 3 0.297331
NUMB numb homolog (Drosophila) 0.293661
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.293281
LRP1B low density lipoprotein receptor-related protein 1B 0.29305
CDADC1 cytidine and dCMP deaminase domain containing 1 0.278535
POM121C POM121 transmembrane nucleoporin C 0.276021
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.273678
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.250903