sinus node Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A small mass of tissue that is embedded in the musculature of the right atrium of higher vertebrates and that originates the impulses stimulating the heartbeat. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004358)
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Genes

203 proteins co-occuring with the tissue sinus node in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 3.30817
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.26202
SCN5A sodium channel, voltage gated, type V alpha subunit 2.15861
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 2.07279
SHOX2 short stature homeobox 2 1.96145
TBX3 T-box 3 1.93939
GJC1 gap junction protein, gamma 1, 45kDa 1.88891
TBX18 T-box 18 1.76977
GJA1 gap junction protein, alpha 1, 43kDa 1.67905
GJA5 gap junction protein, alpha 5, 40kDa 1.62457
USH1G Usher syndrome 1G (autosomal recessive) 1.60117
ANK2 ankyrin 2, neuronal 1.57454
RYR2 ryanodine receptor 2 (cardiac) 1.47101
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 1.45007
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 1.37088
CA5B carbonic anhydrase VB, mitochondrial 1.34134
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.25458
POPDC2 popeye domain containing 2 1.22648
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.20334
TBX2 T-box 2 1.1758
NKX2-5 NK2 homeobox 5 1.07132
NPPA natriuretic peptide A 1.07132
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.05545
SHOX short stature homeobox 1.05457
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.0462
PLN phospholamban 1.01856
TBX5 T-box 5 1.012
ISL1 ISL LIM homeobox 1 1.00719
HOMEZ homeobox and leucine zipper encoding 0.994119
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.988032
CNGB1 cyclic nucleotide gated channel beta 1 0.950393
TBX20 T-box 20 0.948239
ETV3 ets variant 3 0.936629
INA internexin neuronal intermediate filament protein, alpha 0.92291
GATA4 GATA binding protein 4 0.914788
NPR3 natriuretic peptide receptor 3 0.904553
ACHE acetylcholinesterase (Yt blood group) 0.885862
MEGF9 multiple EGF-like-domains 9 0.876129
NPPB natriuretic peptide B 0.868951
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.854629
RGS6 regulator of G-protein signaling 6 0.851266
BVES blood vessel epicardial substance 0.841608
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.838252
PODXL podocalyxin-like 0.832385
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 0.829034
CPLX4 complexin 4 0.820248
MEF2D myocyte enhancer factor 2D 0.78938
BCHE butyrylcholinesterase 0.776494
CHAT choline O-acetyltransferase 0.775664
GPANK1 G patch domain and ankyrin repeats 1 0.767783
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.762811
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.762811
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.76157
NPY neuropeptide Y 0.757432
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.743389
TH tyrosine hydroxylase 0.734735
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.731854
PITX2 paired-like homeodomain 2 0.726097
S1PR3 sphingosine-1-phosphate receptor 3 0.720755
CCNA2 cyclin A2 0.7146
RYR1 ryanodine receptor 1 (skeletal) 0.707631
SCN3B sodium channel, voltage gated, type III beta subunit 0.704355
ANK1 ankyrin 1, erythrocytic 0.699853
EMD emerin 0.692493
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.687184
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 0.687184
TMEM43 transmembrane protein 43 0.684327
MEF2A myocyte enhancer factor 2A 0.676987
CALCA calcitonin-related polypeptide alpha 0.668436
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.667622
IARS isoleucyl-tRNA synthetase 0.663149
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.655836
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.654618
RIC8A RIC8 guanine nucleotide exchange factor A 0.643263
MEF2C myocyte enhancer factor 2C 0.642048
ADCY2 adenylate cyclase 2 (brain) 0.640428
RGS4 regulator of G-protein signaling 4 0.636785
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.625061
MGAM maltase-glucoamylase 0.623043
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.61175
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.608527
CHRM2 cholinergic receptor, muscarinic 2 0.608124
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.606916
PDCL3 phosducin-like 3 0.59646
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.584823
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 0.581218
PHF12 PHD finger protein 12 0.577615
ADRA2B adrenoceptor alpha 2B 0.574017
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.567227
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.566828
TNNT2 troponin T type 2 (cardiac) 0.565232
NPPC natriuretic peptide C 0.558059
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.557263
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.552888
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.548914
ACE angiotensin I converting enzyme 0.533856
ACOT7 acyl-CoA thioesterase 7 0.528719
KIAA0101 KIAA0101 0.524377
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.523194
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.521223
SCN3A sodium channel, voltage gated, type III alpha subunit 0.510599
GFRA2 GDNF family receptor alpha 2 0.506279
ECI1 enoyl-CoA delta isomerase 1 0.502357
PDE4A phosphodiesterase 4A, cAMP-specific 0.499615
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.496092
CAV3 caveolin 3 0.491009
RYR3 ryanodine receptor 3 0.490619
ADCY1 adenylate cyclase 1 (brain) 0.490619
HAUS3 HAUS augmin-like complex, subunit 3 0.489838
DMPK dystrophia myotonica-protein kinase 0.483596
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.479312
TNNI3 troponin I type 3 (cardiac) 0.478145
DNAH8 dynein, axonemal, heavy chain 8 0.472704
CASQ2 calsequestrin 2 (cardiac muscle) 0.470375
RRAD Ras-related associated with diabetes 0.464174
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.454898
REST RE1-silencing transcription factor 0.451428
S1PR2 sphingosine-1-phosphate receptor 2 0.451428
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.447961
SETD7 SET domain containing (lysine methyltransferase) 7 0.444115
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.441426
ADORA1 adenosine A1 receptor 0.439123
GJA4 gap junction protein, alpha 4, 37kDa 0.433374
RCAN2 regulator of calcineurin 2 0.428783
VIP vasoactive intestinal peptide 0.428018
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.425726
IGLV3-10 immunoglobulin lambda variable 3-10 0.424199
SKAP2 src kinase associated phosphoprotein 2 0.422673
ADRB1 adrenoceptor beta 1 0.414673
ARR3 arrestin 3, retinal (X-arrestin) 0.410111
TMEM51 transmembrane protein 51 0.408212
ADCY6 adenylate cyclase 6 0.404418
WRAP73 WD repeat containing, antisense to TP73 0.40328
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.402901
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.401386
SON SON DNA binding protein 0.397979
RPIA ribose 5-phosphate isomerase A 0.393064
GJA3 gap junction protein, alpha 3, 46kDa 0.392686
TAC1 tachykinin, precursor 1 0.388158
THEM5 thioesterase superfamily member 5 0.387781
SST somatostatin 0.38439
TMOD1 tropomodulin 1 0.382131
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.374618
HES4 hes family bHLH transcription factor 4 0.374618
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.373118
RERE arginine-glutamic acid dipeptide (RE) repeats 0.370121
CTRC chymotrypsin C (caldecrin) 0.369373
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.36825
PDE2A phosphodiesterase 2A, cGMP-stimulated 0.367129
ADRB2 adrenoceptor beta 2, surface 0.366007
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.36526
GJA8 gap junction protein, alpha 8, 50kDa 0.360409
CLCN2 chloride channel, voltage-sensitive 2 0.355198
HRH2 histamine receptor H2 0.350372
B3GAT1 beta-1,3-glucuronyltransferase 1 0.348519
BARX1 BARX homeobox 1 0.34371
SSB Sjogren syndrome antigen B (autoantigen La) 0.342602
NRTN neurturin 0.339282
NOTCH1 notch 1 0.33413
INVS inversin 0.331927
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.331194
GCG glucagon 0.331194
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.32753
SCN1B sodium channel, voltage gated, type I beta subunit 0.325335
MYBPC2 myosin binding protein C, fast type 0.321685
TXNRD2 thioredoxin reductase 2 0.315498
HBE1 hemoglobin, epsilon 1 0.312957
SHD Src homology 2 domain containing transforming protein D 0.306805
KNG1 kininogen 1 0.30464
GJB3 gap junction protein, beta 3, 31kDa 0.303559
S1PR1 sphingosine-1-phosphate receptor 1 0.297447
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.296372
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.294223
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.293866
ACOT13 acyl-CoA thioesterase 13 0.289226
NPS neuropeptide S 0.287447
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.287092
PKP2 plakophilin 2 0.287092
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.286381
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.284962
PDPN podoplanin 0.282483
ACTN2 actinin, alpha 2 0.28107
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.276495
PARVA parvin, alpha 0.270214
PRKCSH protein kinase C substrate 80K-H 0.269867
KL klotho 0.267791
EDN1 endothelin 1 0.265381
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.265381
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.262986
ARID1A AT rich interactive domain 1A (SWI-like) 0.256902
PIDD1 p53-induced death domain protein 1 0.255567
THBS4 thrombospondin 4 0.255234
MUT methylmalonyl CoA mutase 0.253578
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.239007
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.236921
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.235167
GATA5 GATA binding protein 5 0.227445
SET SET nuclear proto-oncogene 0.227445
ZFPM2 zinc finger protein, FOG family member 2 0.225395
SAG S-antigen; retina and pineal gland (arrestin) 0.22246
LOXL2 lysyl oxidase-like 2 0.222224
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.220152
SLURP1 secreted LY6/PLAUR domain containing 1 0.217762