sin3-type complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. (Gene Ontology, GO_0070822)
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10 proteins localized to the sin3-type complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MORF4 mortality factor 4 (pseudogene) 0.663342
PHF12 PHD finger protein 12 0.663342
HDAC2 histone deacetylase 2 0.663342
ING2 inhibitor of growth family, member 2 0.663342
FAM60A family with sequence similarity 60, member A 0.663342
SIN3A SIN3 transcription regulator family member A 0.663342
RBBP4 retinoblastoma binding protein 4 0.237908
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.237908
HDAC1 histone deacetylase 1 0.237908
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.237908