sin3 complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. (Gene Ontology, GO_0016580)
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10 proteins localized to the sin3 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MORF4 mortality factor 4 (pseudogene) 0.663342
PHF12 PHD finger protein 12 0.663342
HDAC2 histone deacetylase 2 0.663342
ING2 inhibitor of growth family, member 2 0.663342
FAM60A family with sequence similarity 60, member A 0.663342
SIN3A SIN3 transcription regulator family member A 0.663342
RBBP4 retinoblastoma binding protein 4 0.237908
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.237908
HDAC1 histone deacetylase 1 0.237908
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.237908