sh3/sh2 adaptor activity Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). (Gene Ontology, GO_0005070)
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52 genes performing the sh3/sh2 adaptor activity molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
ARHGAP1 Rho GTPase activating protein 1
ARHGAP4 Rho GTPase activating protein 4
ARHGAP6 Rho GTPase activating protein 6
BLNK B-cell linker
CD28 CD28 molecule
CHN1 chimerin 1
CHN2 chimerin 2
CLNK cytokine-dependent hematopoietic cell linker
CNTNAP1 contactin associated protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
EPS8 epidermal growth factor receptor pathway substrate 8
FCRL2 Fc receptor-like 2
GAB1 GRB2-associated binding protein 1
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HSH2D hematopoietic SH2 domain containing
IRS4 insulin receptor substrate 4
ITSN2 intersectin 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LASP1 LIM and SH3 protein 1
LAT linker for activation of T cells
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RUSC1 RUN and SH3 domain containing 1
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SH2D2A SH2 domain containing 2A
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
SH3BGR SH3 domain binding glutamate-rich protein
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP2 SH3-domain binding protein 2
SHB Src homology 2 domain containing adaptor protein B
SKAP1 src kinase associated phosphoprotein 1
SKAP2 src kinase associated phosphoprotein 2
SLA Src-like-adaptor
SLA2 Src-like-adaptor 2
SOCS2 suppressor of cytokine signaling 2
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAP1 signal transducing adaptor family member 1
TOB1 transducer of ERBB2, 1
TP53BP2 tumor protein p53 binding protein 2
VAV3 vav 3 guanine nucleotide exchange factor