sex differentiation disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

273 genes co-occuring with the disease sex differentiation disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AR androgen receptor 2.84425
SHBG sex hormone-binding globulin 2.56721
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.24311
INS insulin 2.04236
SRY sex determining region Y 2.02884
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.93656
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.8541
POMC proopiomelanocortin 1.80066
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 1.78489
AMH anti-Mullerian hormone 1.7623
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 1.68408
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.60189
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.54849
LHCGR luteinizing hormone/choriogonadotropin receptor 1.4443
PRL prolactin 1.41314
WT1 Wilms tumor 1 1.31974
INSR insulin receptor 1.30314
IGF1 insulin-like growth factor 1 (somatomedin C) 1.29396
IGFBP1 insulin-like growth factor binding protein 1 1.22649
ZFY zinc finger protein, Y-linked 1.20526
LEP leptin 1.14051
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.10048
KLK3 kallikrein-related peptidase 3 1.08915
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.06606
AMHR2 anti-Mullerian hormone receptor, type II 1.05135
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.00879
FSHR follicle stimulating hormone receptor 0.965825
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.913903
ESR1 estrogen receptor 1 0.909787
INSL3 insulin-like 3 (Leydig cell) 0.889668
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.874919
SOX9 SRY (sex determining region Y)-box 9 0.845031
SPAG11A sperm associated antigen 11A 0.831918
SPATA7 spermatogenesis associated 7 0.831508
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.830279
SPAG11B sperm associated antigen 11B 0.793771
DMXL2 Dmx-like 2 0.783526
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.763494
IGFBP3 insulin-like growth factor binding protein 3 0.758601
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.744766
TRH thyrotropin-releasing hormone 0.743547
AASS aminoadipate-semialdehyde synthase 0.741517
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.741517
INHA inhibin, alpha 0.732191
NCOA2 nuclear receptor coactivator 2 0.70434
CGNL1 cingulin-like 1 0.703938
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.685891
PHF6 PHD finger protein 6 0.672722
CRP C-reactive protein, pentraxin-related 0.671527
PGR progesterone receptor 0.665563
STAR steroidogenic acute regulatory protein 0.658818
DHH desert hedgehog 0.648138
TMOD3 tropomodulin 3 (ubiquitous) 0.647348
NAMPT nicotinamide phosphoribosyltransferase 0.605762
PPARG peroxisome proliferator-activated receptor gamma 0.603811
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 0.60264
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.60108
POR P450 (cytochrome) oxidoreductase 0.582384
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.549359
ZFX zinc finger protein, X-linked 0.544318
REN renin 0.524588
CAPN10 calpain 10 0.524588
DENND1A DENN/MADD domain containing 1A 0.518805
GGN gametogenetin 0.518034
IRS1 insulin receptor substrate 1 0.51188
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.495029
AFP alpha-fetoprotein 0.486646
RSPO1 R-spondin 1 0.481705
APOD apolipoprotein D 0.481325
WNT7A wingless-type MMTV integration site family, member 7A 0.478289
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.459751
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.452962
ACE angiotensin I converting enzyme 0.446182
ABI3 ABI family, member 3 0.438282
FST follistatin 0.435651
CLEC2A C-type lectin domain family 2, member A 0.431894
DBT dihydrolipoamide branched chain transacylase E2 0.417644
CRH corticotropin releasing hormone 0.416521
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.409414
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.404557
THADA thyroid adenoma associated 0.403438
AMELY amelogenin, Y-linked 0.399334
SORBS1 sorbin and SH3 domain containing 1 0.39598
PIP prolactin-induced protein 0.390769
GHRH growth hormone releasing hormone 0.372217
DMRT2 doublesex and mab-3 related transcription factor 2 0.358551
HMGA2 high mobility group AT-hook 2 0.352659
DMRT1 doublesex and mab-3 related transcription factor 1 0.349717
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.347511
MAPK6 mitogen-activated protein kinase 6 0.346409
FBN3 fibrillin 3 0.346042
GML glycosylphosphatidylinositol anchored molecule like 0.342006
NMRK2 nicotinamide riboside kinase 2 0.333218
IL6 interleukin 6 0.331756
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.33066
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.325552
FIGLA folliculogenesis specific basic helix-loop-helix 0.324458
BRCA2 breast cancer 2, early onset 0.321909
TLN2 talin 2 0.315729
ZNF274 zinc finger protein 274 0.30848
RETN resistin 0.304503
ACPP acid phosphatase, prostate 0.299452
APOB apolipoprotein B 0.284371
RBP4 retinol binding protein 4, plasma 0.279367
ALG6 ALG6, alpha-1,3-glucosyltransferase 0.277584
GDF9 growth differentiation factor 9 0.266203
ESR2 estrogen receptor 2 (ER beta) 0.264785
GPR83 G protein-coupled receptor 83 0.261599
RAD54B RAD54 homolog B (S. cerevisiae) 0.259124
GHRL ghrelin/obestatin prepropeptide 0.257358
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.254536
KAT7 K(lysine) acetyltransferase 7 0.252774
MAMLD1 mastermind-like domain containing 1 0.25207
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.250663
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.24996
COG2 component of oligomeric golgi complex 2 0.247852
LMNA lamin A/C 0.244696
GLDN gliomedin 0.238752
CSH2 chorionic somatomammotropin hormone 2 0.237706
APOA1 apolipoprotein A-I 0.229716
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.223853
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.222822
YIPF2 Yip1 domain family, member 2 0.222479
ADRB3 adrenoceptor beta 3 0.221793
AMELX amelogenin, X-linked 0.217693
GHR growth hormone receptor 0.217012
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.215653
MKI67 marker of proliferation Ki-67 0.214975
MC4R melanocortin 4 receptor 0.209918
CST1 cystatin SN 0.207912
STXBP3 syntaxin binding protein 3 0.207245
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.205585
STK11 serine/threonine kinase 11 0.204923
FGF9 fibroblast growth factor 9 0.203604
HARS histidyl-tRNA synthetase 0.20229
LY96 lymphocyte antigen 96 0.194865
ALB albumin 0.194232
TBC1D4 TBC1 domain family, member 4 0.193915
NNT nicotinamide nucleotide transhydrogenase 0.193285
NF1 neurofibromin 1 0.189859
FTO fat mass and obesity associated 0.189859
ANLN anillin, actin binding protein 0.187113
IGF2 insulin-like growth factor 2 0.18591
KLF15 Kruppel-like factor 15 0.185016
FOXL2 forkhead box L2 0.182375
ECI1 enoyl-CoA delta isomerase 1 0.180367
CD34 CD34 molecule 0.179802
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.179802
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.176215
F2 coagulation factor II (thrombin) 0.176215
TBX4 T-box 4 0.172799
PEA15 phosphoprotein enriched in astrocytes 15 0.170789
FOXJ2 forkhead box J2 0.170299
ALPPL2 alkaline phosphatase, placental-like 2 0.165001
ALPP alkaline phosphatase, placental 0.164786
ALPL alkaline phosphatase, liver/bone/kidney 0.164571
ECEL1 endothelin converting enzyme-like 1 0.163317
HRH2 histamine receptor H2 0.162908
BBS9 Bardet-Biedl syndrome 9 0.162306
PLG plasminogen 0.162109
CSN2 casein beta 0.158605
ATAD3C ATPase family, AAA domain containing 3C 0.141598
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.141545
RXFP2 relaxin/insulin-like family peptide receptor 2 0.140905
HDC histidine decarboxylase 0.140543
PRM1 protamine 1 0.139781
BEST1 bestrophin 1 0.13959
ARAF A-Raf proto-oncogene, serine/threonine kinase 0.139135
TSPY1 testis specific protein, Y-linked 1 0.138275
MEA1 male-enhanced antigen 1 0.137929
CTRL chymotrypsin-like 0.137893
ATL1 atlastin GTPase 1 0.137809
SET SET nuclear proto-oncogene 0.137651
PIAS3 protein inhibitor of activated STAT, 3 0.137639
HOXA5 homeobox A5 0.136848
TSPY10 testis specific protein, Y-linked 10 0.136771
TSPY3 testis specific protein, Y-linked 3 0.136771
PON3 paraoxonase 3 0.13587
GUSB glucuronidase, beta 0.13587
BMP15 bone morphogenetic protein 15 0.135823
FHL1 four and a half LIM domains 1 0.135672
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.135378
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.135319
POU5F1B POU class 5 homeobox 1B 0.134889
IGFBP5 insulin-like growth factor binding protein 5 0.133659
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.133371
TBX3 T-box 3 0.133319
CRYGB crystallin, gamma B 0.132811
ACTN4 actinin, alpha 4 0.132096
DHCR7 7-dehydrocholesterol reductase 0.131342
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.13068
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.129709
ADD2 adducin 2 (beta) 0.128537
PAX2 paired box 2 0.127931
UBC ubiquitin C 0.127706
MPG N-methylpurine-DNA glycosylase 0.127565
RPS27A ribosomal protein S27a 0.127279
CUTA cutA divalent cation tolerance homolog (E. coli) 0.126707
GH1 growth hormone 1 0.126688
HOXD10 homeobox D10 0.126669
KLF10 Kruppel-like factor 10 0.126189
RHCG Rh family, C glycoprotein 0.126031
MIR197 microRNA 197 0.125732
UBB ubiquitin B 0.12484
MECOM MDS1 and EVI1 complex locus 0.124602
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.124384
XG Xg blood group 0.123689
TAC3 tachykinin 3 0.123106
KRT14 keratin 14, type I 0.1226
AVP arginine vasopressin 0.122153
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.121979
NOTCH1 notch 1 0.121851
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.121284
SOX5 SRY (sex determining region Y)-box 5 0.121258
PDGFA platelet-derived growth factor alpha polypeptide 0.119729
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.119673
BSN bassoon presynaptic cytomatrix protein 0.119215
CALB2 calbindin 2 0.117903
HDAC8 histone deacetylase 8 0.117716
ERBB2 erb-b2 receptor tyrosine kinase 2 0.117216
MLANA melan-A 0.116832
AKR1C3 aldo-keto reductase family 1, member C3 0.115949
DAND5 DAN domain family member 5, BMP antagonist 0.115311
TACR3 tachykinin receptor 3 0.115311
IRS4 insulin receptor substrate 4 0.115208
GATA6 GATA binding protein 6 0.115139
SDC3 syndecan 3 0.115036
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.11448
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.11441
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.113949
TRPS1 trichorhinophalangeal syndrome I 0.113698
SYNPO synaptopodin 0.113552
FRY furry homolog (Drosophila) 0.113479
SOX3 SRY (sex determining region Y)-box 3 0.113333
POLK polymerase (DNA directed) kappa 0.113333
DCLRE1C DNA cross-link repair 1C 0.113077
ADD1 adducin 1 (alpha) 0.112856
GAB1 GRB2-associated binding protein 1 0.112819
PROKR2 prokineticin receptor 2 0.111991
CD2AP CD2-associated protein 0.111913
MIR183 microRNA 183 0.111681
CRLF1 cytokine receptor-like factor 1 0.111564
FEN1 flap structure-specific endonuclease 1 0.111564
WNT10B wingless-type MMTV integration site family, member 10B 0.111371
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 0.109981
SLC35E2B solute carrier family 35, member E2B 0.109817
CLEC3A C-type lectin domain family 3, member A 0.109571
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.10953
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 0.10953
CYTL1 cytokine-like 1 0.109407
CYS1 cystin 1 0.109202
CLEC2B C-type lectin domain family 2, member B 0.109036
GREB1 growth regulation by estrogen in breast cancer 1 0.10891
CES1 carboxylesterase 1 0.108572
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.108277
HIRA histone cell cycle regulator 0.107416
TRO trophinin 0.106626
LMNB2 lamin B2 0.106537
CLEC10A C-type lectin domain family 10, member A 0.106358
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.106225
GGT2 gamma-glutamyltransferase 2 0.105822
AQP9 aquaporin 9 0.105045
BRCA1 breast cancer 1, early onset 0.104908
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.104723
MN1 meningioma (disrupted in balanced translocation) 1 0.104395
PGC progastricsin (pepsinogen C) 0.10416
EED embryonic ectoderm development 0.104067
CST4 cystatin S 0.103453
EXOSC4 exosome component 4 0.103212
INHBA inhibin, beta A 0.103068
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.102245
POU5F1 POU class 5 homeobox 1 0.102048
PROP1 PROP paired-like homeobox 1 0.101999