serotonin-2449 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the serotonin-2449 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AIF1 allograft inflammatory factor 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANGPTL2 angiopoietin-like 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOE apolipoprotein E
AR androgen receptor
ARHGAP32 Rho GTPase activating protein 32
ARHGAP44 Rho GTPase activating protein 44
ARRB1 arrestin, beta 1
ASPH aspartate beta-hydroxylase
ATP13A2 ATPase type 13A2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AURKA aurora kinase A
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BEND5 BEN domain containing 5
BMP8A bone morphogenetic protein 8a
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNK cyclin K
CD59 CD59 molecule, complement regulatory protein
CDC25C cell division cycle 25C
CDRT1 CMT1A duplicated region transcript 1
CHM choroideremia (Rab escort protein 1)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DRD2 dopamine receptor D2
DSTYK dual serine/threonine and tyrosine protein kinase
EFNA3 ephrin-A3
EIF1 eukaryotic translation initiation factor 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOC7 exocyst complex component 7
FANCA Fanconi anemia, complementation group A
GJC1 gap junction protein, gamma 1, 45kDa
HN1L hematological and neurological expressed 1-like
HPX hemopexin
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
INCENP inner centromere protein antigens 135/155kDa
IQCK IQ motif containing K
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KAT8 K(lysine) acetyltransferase 8
KIAA0087 KIAA0087
KIAA1654 KIAA1654 protein
KRT9 keratin 9, type I
MAX MYC associated factor X
MBP myelin basic protein
MED25 mediator complex subunit 25
MLXIPL MLX interacting protein-like
MRPS12 mitochondrial ribosomal protein S12
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NDRG3 NDRG family member 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOX1 NADPH oxidase 1
NPC1 Niemann-Pick disease, type C1
NRF1 nuclear respiratory factor 1
NRP2 neuropilin 2
NUP214 nucleoporin 214kDa
PCGF2 polycomb group ring finger 2
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB6A RAB6A, member RAS oncogene family
RND1 Rho family GTPase 1
SDS serine dehydratase
SIX1 SIX homeobox 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD5 SMAD family member 5
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPAG8 sperm associated antigen 8
SPATA2L spermatogenesis associated 2-like
SS18 synovial sarcoma translocation, chromosome 18
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAT2 signal transducer and activator of transcription 2, 113kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX6 T-box 6
THSD7A thrombospondin, type I, domain containing 7A
TNC tenascin C
TRBC1 T cell receptor beta constant 1
TRIM62 tripartite motif containing 62
TULP2 tubby like protein 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
ZBTB22 zinc finger and BTB domain containing 22
ZC3H7B zinc finger CCCH-type containing 7B
ZNF174 zinc finger protein 174
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AMH anti-Mullerian hormone
AOAH acyloxyacyl hydrolase (neutrophil)
APOL6 apolipoprotein L, 6
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AXIN1 axin 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C16ORF59 chromosome 16 open reading frame 59
C9ORF9 chromosome 9 open reading frame 9
CCDC176 coiled-coil domain containing 176
CD79A CD79a molecule, immunoglobulin-associated alpha
CHMP1A charged multivesicular body protein 1A
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNPY4 canopy FGF signaling regulator 4
COL15A1 collagen, type XV, alpha 1
CPNE7 copine VII
CTSO cathepsin O
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DOK3 docking protein 3
DPEP2 dipeptidase 2
DSPP dentin sialophosphoprotein
EMID1 EMI domain containing 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
FCHO1 FCH domain only 1
FGF23 fibroblast growth factor 23
FGGY FGGY carbohydrate kinase domain containing
FLT4 fms-related tyrosine kinase 4
G6PD glucose-6-phosphate dehydrogenase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GATA6 GATA binding protein 6
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GJA8 gap junction protein, alpha 8, 50kDa
GRIP2 glutamate receptor interacting protein 2
HAMP hepcidin antimicrobial peptide
HIST1H2BN histone cluster 1, H2bn
HP haptoglobin
HPSE heparanase
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL3RA interleukin 3 receptor, alpha (low affinity)
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCTD7 potassium channel tetramerization domain containing 7
KLHL28 kelch-like family member 28
LINS lines homolog (Drosophila)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC20 leucine rich repeat containing 20
MANSC1 MANSC domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCOLN1 mucolipin 1
MRAS muscle RAS oncogene homolog
MTERF1 mitochondrial transcription termination factor 1
MX2 MX dynamin-like GTPase 2
MYL5 myosin, light chain 5, regulatory
NCKAP1L NCK-associated protein 1-like
NEUROD4 neuronal differentiation 4
NIPAL2 NIPA-like domain containing 2
NXPH4 neurexophilin 4
OLFML2A olfactomedin-like 2A
OXCT2 3-oxoacid CoA transferase 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDGFRL platelet-derived growth factor receptor-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTCD1 pentatricopeptide repeat domain 1
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RCAN3 RCAN family member 3
RNF2 ring finger protein 2
RPAP1 RNA polymerase II associated protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMYD5 SMYD family member 5
SNAI1 snail family zinc finger 1
SPATA1 spermatogenesis associated 1
STX11 syntaxin 11
TCTN2 tectonic family member 2
TIGD6 tigger transposable element derived 6
TMEM206 transmembrane protein 206
TRAF2 TNF receptor-associated factor 2
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
TUFT1 tuftelin 1
VEGFC vascular endothelial growth factor C
VWA1 von Willebrand factor A domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF493 zinc finger protein 493
ZNF701 zinc finger protein 701
ZNF862 zinc finger protein 862