securinine-3470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the securinine-3470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AKAP11 A kinase (PRKA) anchor protein 11
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALMS1 Alstrom syndrome protein 1
AREG amphiregulin
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARTN artemin
ATXN7L3B ataxin 7-like 3B
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC85B coiled-coil domain containing 85B
CD70 CD70 molecule
CDC25A cell division cycle 25A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DIO2 deiodinase, iodothyronine, type II
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EPOR erythropoietin receptor
ERC2-IT1 ERC2 intronic transcript 1
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM155B family with sequence similarity 155, member B
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FOSL1 FOS-like antigen 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD10 frizzled class receptor 10
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H1D histone cluster 1, H1d
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1L heat shock 70kDa protein 1-like
IGFBP5 insulin-like growth factor binding protein 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ITGB5 integrin, beta 5
JAK2 Janus kinase 2
LDB1 LIM domain binding 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MED16 mediator complex subunit 16
MED18 mediator complex subunit 18
MEFV Mediterranean fever
METTL7A methyltransferase like 7A
MRPL41 mitochondrial ribosomal protein L41
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL10 myosin, light chain 10, regulatory
NCOA2 nuclear receptor coactivator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFYA nuclear transcription factor Y, alpha
NMT1 N-myristoyltransferase 1
NPY5R neuropeptide Y receptor Y5
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
PARD6B par-6 family cell polarity regulator beta
PAX5 paired box 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCE protein kinase C, epsilon
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PVR poliovirus receptor
RNF2 ring finger protein 2
RNFT1 ring finger protein, transmembrane 1
RPL10L ribosomal protein L10-like
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TMEM120B transmembrane protein 120B
TMEM63A transmembrane protein 63A
TRIM16 tripartite motif containing 16
UBE3A ubiquitin protein ligase E3A
USP34 ubiquitin specific peptidase 34
VGF VGF nerve growth factor inducible
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YTHDC1 YTH domain containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZHX3 zinc fingers and homeoboxes 3
ZNF117 zinc finger protein 117
ZNF286A zinc finger protein 286A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF419 zinc finger protein 419

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASB9 ankyrin repeat and SOCS box containing 9
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAHD1 bromo adjacent homology domain containing 1
BFSP1 beaded filament structural protein 1, filensin
C11ORF80 chromosome 11 open reading frame 80
C16ORF45 chromosome 16 open reading frame 45
C2ORF54 chromosome 2 open reading frame 54
CAPN15 calpain 15
CASD1 CAS1 domain containing 1
CASZ1 castor zinc finger 1
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CDK20 cyclin-dependent kinase 20
CEP170B centrosomal protein 170B
CFD complement factor D (adipsin)
CLMN calmin (calponin-like, transmembrane)
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTX4 deltex 4, E3 ubiquitin ligase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA1 ephrin-A1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELOVL4 ELOVL fatty acid elongase 4
EPHA4 EPH receptor A4
F8 coagulation factor VIII, procoagulant component
FAM169A family with sequence similarity 169, member A
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GATA6 GATA binding protein 6
HDAC4 histone deacetylase 4
HOXC11 homeobox C11
HPS6 Hermansky-Pudlak syndrome 6
HS1BP3 HCLS1 binding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFT81 intraflagellar transport 81
IRF9 interferon regulatory factor 9
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0513 KIAA0513
KIF13B kinesin family member 13B
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRRC8E leucine rich repeat containing 8 family, member E
LYPD3 LY6/PLAUR domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK12 mitogen-activated protein kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MCOLN3 mucolipin 3
MRPL52 mitochondrial ribosomal protein L52
MSMB microseminoprotein, beta-
MUM1 melanoma associated antigen (mutated) 1
NDRG4 NDRG family member 4
NKAIN1 Na+/K+ transporting ATPase interacting 1
NMU neuromedin U
NREP neuronal regeneration related protein
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI2 peptidyl arginine deiminase, type II
PARD6A par-6 family cell polarity regulator alpha
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PROS1 protein S (alpha)
PTPRU protein tyrosine phosphatase, receptor type, U
RNF123 ring finger protein 123
SELENBP1 selenium binding protein 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFXN3 sideroflexin 3
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIDT1 SID1 transmembrane family, member 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC46A3 solute carrier family 46, member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP1 Sp1 transcription factor
STAG3 stromal antigen 3
TCEAL1 transcription elongation factor A (SII)-like 1
TRIM45 tripartite motif containing 45
TRIM5 tripartite motif containing 5
TUBA3C tubulin, alpha 3c
XYLT2 xylosyltransferase II
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF211 zinc finger protein 211
ZNF280D zinc finger protein 280D
ZNF324 zinc finger protein 324
ZNF623 zinc finger protein 623