sanguinarine-2927 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sanguinarine-2927 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AQP1 aquaporin 1 (Colton blood group)
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BMP6 bone morphogenetic protein 6
CLU clusterin
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EPS8L1 EPS8-like 1
ESRP1 epithelial splicing regulatory protein 1
FAM46C family with sequence similarity 46, member C
FBXL14 F-box and leucine-rich repeat protein 14
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLB1L galactosidase, beta 1-like
HES1 hes family bHLH transcription factor 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
HIST1H2AM histone cluster 1, H2am
HIST1H2BG histone cluster 1, H2bg
HIST1H3A histone cluster 1, H3a
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIST1H3I histone cluster 1, H3i
HIST1H3J histone cluster 1, H3j
HIST1H4A histone cluster 1, H4a
HIST1H4B histone cluster 1, H4b
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HIST1H4J histone cluster 1, H4j
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL24 interleukin 24
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLHL25 kelch-like family member 25
LRRC23 leucine rich repeat containing 23
MMP1 matrix metallopeptidase 1
MMP19 matrix metallopeptidase 19
MRPL18 mitochondrial ribosomal protein L18
MT1G metallothionein 1G
MT2A metallothionein 2A
MXD1 MAX dimerization protein 1
NOV nephroblastoma overexpressed
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RPL13P5 ribosomal protein L13 pseudogene 5
RSRC2 arginine/serine-rich coiled-coil 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
THBS1 thrombospondin 1
TMEM143 transmembrane protein 143
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN13 tetraspanin 13
USPL1 ubiquitin specific peptidase like 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACYP1 acylphosphatase 1, erythrocyte (common) type
AGO1 argonaute RISC catalytic component 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
APOLD1 apolipoprotein L domain containing 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
BHLHE40 basic helix-loop-helix family, member e40
C1ORF106 chromosome 1 open reading frame 106
C8ORF60 chromosome 8 open reading frame 60
CAAP1 caspase activity and apoptosis inhibitor 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBR4 carbonyl reductase 4
CCDC47 coiled-coil domain containing 47
CCL2 chemokine (C-C motif) ligand 2
CD302 CD302 molecule
CDC7 cell division cycle 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTPS1 CTP synthase 1
DCAF6 DDB1 and CUL4 associated factor 6
DDHD2 DDHD domain containing 2
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYD dihydropyrimidine dehydrogenase
E2F8 E2F transcription factor 8
ELOVL6 ELOVL fatty acid elongase 6
FAM188A family with sequence similarity 188, member A
FAR2 fatty acyl CoA reductase 2
FOXJ2 forkhead box J2
FPGT fucose-1-phosphate guanylyltransferase
GCA grancalcin, EF-hand calcium binding protein
GFI1 growth factor independent 1 transcription repressor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GMCL1 germ cell-less, spermatogenesis associated 1
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
IMPACT impact RWD domain protein
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM3A lysine (K)-specific demethylase 3A
KIAA0922 KIAA0922
LINC00341 long intergenic non-protein coding RNA 341
LRRC37A2 leucine rich repeat containing 37, member A2
LRRC42 leucine rich repeat containing 42
LY75 lymphocyte antigen 75
MNS1 meiosis-specific nuclear structural 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
NPIPB3 nuclear pore complex interacting protein family, member B3
OXCT1 3-oxoacid CoA transferase 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGRMC2 progesterone receptor membrane component 2
PIEZO1 piezo-type mechanosensitive ion channel component 1
POGK pogo transposable element with KRAB domain
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RABL3 RAB, member of RAS oncogene family-like 3
RARS arginyl-tRNA synthetase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM38 RNA binding motif protein 38
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REEP4 receptor accessory protein 4
RGS13 regulator of G-protein signaling 13
RINT1 RAD50 interactor 1
RPIA ribose 5-phosphate isomerase A
RRAS related RAS viral (r-ras) oncogene homolog
RSBN1 round spermatid basic protein 1
SACS sacsin molecular chaperone
SEH1L SEH1-like (S. cerevisiae)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFXN3 sideroflexin 3
SLA Src-like-adaptor
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
STK39 serine threonine kinase 39
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGM5 transglutaminase 5
TMEM183A transmembrane protein 183A
TMEM38B transmembrane protein 38B
TMEM45A transmembrane protein 45A
TNF tumor necrosis factor
TRIM8 tripartite motif containing 8
TUBGCP5 tubulin, gamma complex associated protein 5
UBA5 ubiquitin-like modifier activating enzyme 5
WDR3 WD repeat domain 3
WT1 Wilms tumor 1
ZBED1 zinc finger, BED-type containing 1
ZNRD1-AS1 ZNRD1 antisense RNA 1