roxarsone-5470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the roxarsone-5470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTSL4 ADAMTS-like 4
ALDOB aldolase B, fructose-bisphosphate
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
BCL2L1 BCL2-like 1
BIN1 bridging integrator 1
BMP2 bone morphogenetic protein 2
BPY2 basic charge, Y-linked, 2
CASD1 CAS1 domain containing 1
CCDC93 coiled-coil domain containing 93
CD300C CD300c molecule
CES3 carboxylesterase 3
CFLAR CASP8 and FADD-like apoptosis regulator
CLEC11A C-type lectin domain family 11, member A
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COLEC10 collectin sub-family member 10 (C-type lectin)
CRABP1 cellular retinoic acid binding protein 1
CROCC ciliary rootlet coiled-coil, rootletin
CSF1R colony stimulating factor 1 receptor
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DFNB31 deafness, autosomal recessive 31
DST dystonin
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ENO3 enolase 3 (beta, muscle)
ERAP1 endoplasmic reticulum aminopeptidase 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM120C family with sequence similarity 120C
FGF9 fibroblast growth factor 9
FRMPD1 FERM and PDZ domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GAL galanin/GMAP prepropeptide
GLB1L galactosidase, beta 1-like
GNS glucosamine (N-acetyl)-6-sulfatase
GSTA4 glutathione S-transferase alpha 4
HNMT histamine N-methyltransferase
IFT140 intraflagellar transport 140
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
KIF21B kinesin family member 21B
KIF5A kinesin family member 5A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
LEFTY2 left-right determination factor 2
LINC00597 long intergenic non-protein coding RNA 597
LOXL2 lysyl oxidase-like 2
LRRC23 leucine rich repeat containing 23
MAGEA5 melanoma antigen family A5
MCF2L MCF.2 cell line derived transforming sequence-like
MKL1 megakaryoblastic leukemia (translocation) 1
MPO myeloperoxidase
MYBPC3 myosin binding protein C, cardiac
MZF1 myeloid zinc finger 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NOX1 NADPH oxidase 1
PDLIM5 PDZ and LIM domain 5
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POFUT1 protein O-fucosyltransferase 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRPF31 pre-mRNA processing factor 31
PTBP3 polypyrimidine tract binding protein 3
PYGB phosphorylase, glycogen; brain
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBBP4 retinoblastoma binding protein 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF6 ring finger protein (C3H2C3 type) 6
RPH3A rabphilin 3A
RPS6 ribosomal protein S6
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNDC3A RUN domain containing 3A
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SIRT3 sirtuin 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SP1 Sp1 transcription factor
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRRT serrate, RNA effector molecule
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAOK2 TAO kinase 2
TBC1D2B TBC1 domain family, member 2B
TFPI2 tissue factor pathway inhibitor 2
TK2 thymidine kinase 2, mitochondrial
TNPO2 transportin 2
TRIM25 tripartite motif containing 25
TRIO trio Rho guanine nucleotide exchange factor
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDFY3 WD repeat and FYVE domain containing 3
WDR76 WD repeat domain 76
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WTAP Wilms tumor 1 associated protein
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZNF204P zinc finger protein 204, pseudogene
ZNF318 zinc finger protein 318
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG7 autophagy related 7
ATP7B ATPase, Cu++ transporting, beta polypeptide
BTBD2 BTB (POZ) domain containing 2
BTF3P12 basic transcription factor 3 pseudogene 12
CBX4 chromobox homolog 4
CCDC88C coiled-coil domain containing 88C
CCNL2 cyclin L2
CD302 CD302 molecule
CDKN2AIP CDKN2A interacting protein
CENPO centromere protein O
CEP170B centrosomal protein 170B
CGREF1 cell growth regulator with EF-hand domain 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CISH cytokine inducible SH2-containing protein
CLASRP CLK4-associating serine/arginine rich protein
CLDN9 claudin 9
CTDNEP1 CTD nuclear envelope phosphatase 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DET1 de-etiolated homolog 1 (Arabidopsis)
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ENO2 enolase 2 (gamma, neuronal)
ETAA1 Ewing tumor-associated antigen 1
FAM186A family with sequence similarity 186, member A
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
GAS8 growth arrest-specific 8
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL1 guanine nucleotide binding protein-like 1
HMHA1 histocompatibility (minor) HA-1
HMOX1 heme oxygenase 1
HPS6 Hermansky-Pudlak syndrome 6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
INO80D INO80 complex subunit D
IRF6 interferon regulatory factor 6
JMJD4 jumonji domain containing 4
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM5C lysine (K)-specific demethylase 5C
KIAA0556 KIAA0556
KLC2 kinesin light chain 2
KLF2 Kruppel-like factor 2
KRI1 KRI1 homolog (S. cerevisiae)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIN7B lin-7 homolog B (C. elegans)
LRP2 low density lipoprotein receptor-related protein 2
MAGOHB mago-nashi homolog B (Drosophila)
MANBA mannosidase, beta A, lysosomal
MOSPD3 motile sperm domain containing 3
NHEJ1 nonhomologous end-joining factor 1
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUD3 OTU deubiquitinase 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PC pyruvate carboxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POMZP3 POM121 and ZP3 fusion
POPDC3 popeye domain containing 3
PRSS8 protease, serine, 8
PSKH1 protein serine kinase H1
PTK6 protein tyrosine kinase 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASA2 RAS p21 protein activator 2
RIBC2 RIB43A domain with coiled-coils 2
RNF43 ring finger protein 43
SCAI suppressor of cancer cell invasion
SCML2 sex comb on midleg-like 2 (Drosophila)
SETMAR SET domain and mariner transposase fusion gene
SH2B3 SH2B adaptor protein 3
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPHK1 sphingosine kinase 1
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
STARD13 StAR-related lipid transfer (START) domain containing 13
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM57 transmembrane protein 57
TRAPPC11 trafficking protein particle complex 11
TTC23 tetratricopeptide repeat domain 23
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR19 WD repeat domain 19
XYLT2 xylosyltransferase II
ZNF574 zinc finger protein 574
ZNF586 zinc finger protein 586
ZNF639 zinc finger protein 639
ZNF701 zinc finger protein 701