rough endoplasmic reticulum Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. (Gene Ontology, GO_0005791)
Similar Terms
Downloads & Tools

Genes

332 proteins co-occuring with the rough endoplasmic reticulum cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.82524
ACPP acid phosphatase, prostate 1.4593
RPN1 ribophorin I 1.45421
PRL prolactin 1.25022
COMP cartilage oligomeric matrix protein 1.16901
TG thyroglobulin 1.15928
ALPPL2 alkaline phosphatase, placental-like 2 1.09442
ALPP alkaline phosphatase, placental 1.09391
ALPL alkaline phosphatase, liver/bone/kidney 1.0934
INS insulin 1.06701
POMC proopiomelanocortin 1.04431
GAB2 GRB2-associated binding protein 2 1.0408
FN1 fibronectin 1 1.02679
ALB albumin 1.02181
SEC62 SEC62 homolog (S. cerevisiae) 1.00497
ENGASE endo-beta-N-acetylglucosaminidase 1.00448
SEC63 SEC63 homolog (S. cerevisiae) 0.962146
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.95831
A1BG alpha-1-B glycoprotein 0.952573
RPN2 ribophorin II 0.941636
CANX calnexin 0.906926
IRS1 insulin receptor substrate 1 0.850665
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.839187
DNAH8 dynein, axonemal, heavy chain 8 0.811652
MATN3 matrilin 3 0.802479
SRPR signal recognition particle receptor (docking protein) 0.799728
HSPA4 heat shock 70kDa protein 4 0.790106
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.780954
GAB3 GRB2-associated binding protein 3 0.771819
PTH parathyroid hormone 0.770451
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.766804
SAMM50 SAMM50 sorting and assembly machinery component 0.766804
CALR calreticulin 0.756799
P4HB prolyl 4-hydroxylase, beta polypeptide 0.75181
NPTN neuroplastin 0.75181
AFP alpha-fetoprotein 0.740965
CD79A CD79a molecule, immunoglobulin-associated alpha 0.729732
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.721242
ACHE acetylcholinesterase (Yt blood group) 0.719015
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.711465
NT5E 5'-nucleotidase, ecto (CD73) 0.711465
CD34 CD34 molecule 0.707039
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.704831
IRS2 insulin receptor substrate 2 0.703067
LYZ lysozyme 0.688139
TSHB thyroid stimulating hormone, beta 0.68639
GRB2 growth factor receptor-bound protein 2 0.681155
CYB5A cytochrome b5 type A (microsomal) 0.680284
FTH1 ferritin, heavy polypeptide 1 0.679849
SST somatostatin 0.672026
FRS2 fibroblast growth factor receptor substrate 2 0.659913
CALCA calcitonin-related polypeptide alpha 0.656464
GCG glucagon 0.654311
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.651299
APOB apolipoprotein B 0.650439
SRP54 signal recognition particle 54kDa 0.64958
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.648721
FTL ferritin, light polypeptide 0.636723
INSR insulin receptor 0.61968
CSN1S1 casein alpha s1 0.611201
TMEM57 transmembrane protein 57 0.606973
IRS4 insulin receptor substrate 4 0.604017
TF transferrin 0.592232
CKAP4 cytoskeleton-associated protein 4 0.590553
ENO2 enolase 2 (gamma, neuronal) 0.58678
DERL1 derlin 1 0.583012
CAT catalase 0.58134
TRH thyrotropin-releasing hormone 0.577999
CD68 CD68 molecule 0.574662
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.571745
SRPX sushi-repeat containing protein, X-linked 0.551012
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.542764
REN renin 0.539883
P3H1 prolyl 3-hydroxylase 1 0.53906
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.53454
LMAN1 lectin, mannose-binding, 1 0.531258
MTTP microsomal triglyceride transfer protein 0.529618
TSPO translocator protein (18kDa) 0.510826
CABP5 calcium binding protein 5 0.501476
BGLAP bone gamma-carboxyglutamate (gla) protein 0.497015
G6PC glucose-6-phosphatase, catalytic subunit 0.495395
THY1 Thy-1 cell surface antigen 0.493371
PHF20 PHD finger protein 20 0.489731
MOGS mannosyl-oligosaccharide glucosidase 0.484886
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.483676
DERL3 derlin 3 0.482064
CABP2 calcium binding protein 2 0.476831
COL2A1 collagen, type II, alpha 1 0.475223
HDLBP high density lipoprotein binding protein 0.473617
GPX5 glutathione peroxidase 5 0.472813
CD44 CD44 molecule (Indian blood group) 0.468401
GPX4 glutathione peroxidase 4 0.466799
BCHE butyrylcholinesterase 0.458803
ISOC1 isochorismatase domain containing 1 0.458404
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.457208
TRAM1 translocation associated membrane protein 1 0.456012
GPX1 glutathione peroxidase 1 0.455613
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.453223
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.452825
MGAT4C MGAT4 family, member C 0.452029
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.448451
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.447259
TMCC1 transmembrane and coiled-coil domain family 1 0.446862
CHGA chromogranin A 0.444482
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.442104
ANPEP alanyl (membrane) aminopeptidase 0.441312
CCK cholecystokinin 0.437356
CSH2 chorionic somatomammotropin hormone 2 0.434591
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.433407
DAD1 defender against cell death 1 0.433012
GAST gastrin 0.432618
PEX14 peroxisomal biogenesis factor 14 0.432618
ACAN aggrecan 0.426711
XBP1 X-box binding protein 1 0.426318
TGFB1 transforming growth factor, beta 1 0.423567
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.418468
MGAM maltase-glucoamylase 0.416902
F8 coagulation factor VIII, procoagulant component 0.416511
CRTAP cartilage associated protein 0.416511
GUSB glucuronidase, beta 0.412601
MUC2 mucin 2, oligomeric mucus/gel-forming 0.41143
PCNA proliferating cell nuclear antigen 0.404415
SYP synaptophysin 0.404415
SERP1 stress-associated endoplasmic reticulum protein 1 0.40247
FGF20 fibroblast growth factor 20 0.397423
COL1A2 collagen, type I, alpha 2 0.397035
CHRDL1 chordin-like 1 0.396648
NPS neuropeptide S 0.393936
MAN1A1 mannosidase, alpha, class 1A, member 1 0.392775
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.392388
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 0.392001
FGF2 fibroblast growth factor 2 (basic) 0.390068
NTS neurotensin 0.390068
TGOLN2 trans-golgi network protein 2 0.388909
TRAM2 translocation associated membrane protein 2 0.38428
ERVW-1 endogenous retrovirus group W, member 1 0.381584
SPRY4 sprouty homolog 4 (Drosophila) 0.381199
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.375818
LHFPL5 lipoma HMGIC fusion partner-like 5 0.369684
THBS3 thrombospondin 3 0.367388
GPR137B G protein-coupled receptor 137B 0.367388
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 0.367388
TPO thyroid peroxidase 0.365095
PLP1 proteolipid protein 1 0.363185
NRM nurim (nuclear envelope membrane protein) 0.362422
OPCML opioid binding protein/cell adhesion molecule-like 0.361277
DPP4 dipeptidyl-peptidase 4 0.360896
TH tyrosine hydroxylase 0.359371
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.358228
NOMO1 NODAL modulator 1 0.350243
TMCC2 transmembrane and coiled-coil domain family 2 0.349484
RBM28 RNA binding motif protein 28 0.347208
HEXB hexosaminidase B (beta polypeptide) 0.347208
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.346829
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.343421
AMELX amelogenin, X-linked 0.342664
CTSD cathepsin D 0.341529
SOD2 superoxide dismutase 2, mitochondrial 0.340017
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.339639
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.338884
VWF von Willebrand factor 0.337373
DOK2 docking protein 2, 56kDa 0.335864
AMELY amelogenin, Y-linked 0.335864
TAC1 tachykinin, precursor 1 0.333602
PLLP plasmolipin 0.332095
ACP2 acid phosphatase 2, lysosomal 0.330966
DSPP dentin sialophosphoprotein 0.329084
F2 coagulation factor II (thrombin) 0.328708
IGF1 insulin-like growth factor 1 (somatomedin C) 0.328332
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.324951
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.321201
EDA ectodysplasin A 0.319702
LAP3 leucine aminopeptidase 3 0.318953
GAB1 GRB2-associated binding protein 1 0.317082
RAB1A RAB1A, member RAS oncogene family 0.316708
CTSW cathepsin W 0.315212
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.314465
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.313718
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.311851
CELA1 chymotrypsin-like elastase family, member 1 0.311105
CLEC17A C-type lectin domain family 17, member A 0.308494
CGA glycoprotein hormones, alpha polypeptide 0.307749
ESR1 estrogen receptor 1 0.305515
SI sucrase-isomaltase (alpha-glucosidase) 0.304771
CANT1 calcium activated nucleotidase 1 0.304027
CELA3B chymotrypsin-like elastase family, member 3B 0.30254
EPOR erythropoietin receptor 0.300682
GLB1 galactosidase, beta 1 0.29994
MATN1 matrilin 1, cartilage matrix protein 0.299569
NRBP1 nuclear receptor binding protein 1 0.298826
GPR45 G protein-coupled receptor 45 0.297342
PEX11B peroxisomal biogenesis factor 11 beta 0.295119
DOLK dolichol kinase 0.294748
EDN1 endothelin 1 0.293637
STAU1 staufen double-stranded RNA binding protein 1 0.293267
RPL23 ribosomal protein L23 0.291047
FKBP10 FK506 binding protein 10, 65 kDa 0.289569
PRNP prion protein 0.289199
PSG5 pregnancy specific beta-1-glycoprotein 5 0.286245
NTM neurotrimin 0.284032
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.283295
IL3 interleukin 3 0.27998
FSHB follicle stimulating hormone, beta polypeptide 0.279612
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.275569
ERP27 endoplasmic reticulum protein 27 0.273734
TYR tyrosinase 0.273
GGT1 gamma-glutamyltransferase 1 0.272267
FMOD fibromodulin 0.271167
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.2708
KRAS Kirsten rat sarcoma viral oncogene homolog 0.269335
GSTA3 glutathione S-transferase alpha 3 0.268603
CHAT choline O-acetyltransferase 0.267871
PPY pancreatic polypeptide 0.267505
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.267139
GSTA4 glutathione S-transferase alpha 4 0.267139
GSTA2 glutathione S-transferase alpha 2 0.267139
GSTA1 glutathione S-transferase alpha 1 0.264946
MAN1B1 mannosidase, alpha, class 1B, member 1 0.264215
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.262025
MBP myelin basic protein 0.261296
LAMP1 lysosomal-associated membrane protein 1 0.261296
GGT2 gamma-glutamyltransferase 2 0.260202
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.260202
LALBA lactalbumin, alpha- 0.259473
COL8A2 collagen, type VIII, alpha 2 0.258745
TFRC transferrin receptor 0.257652
HM13 histocompatibility (minor) 13 0.257289
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.256561
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.255107
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.25438
GHRH growth hormone releasing hormone 0.254017
DDIT3 DNA-damage-inducible transcript 3 0.251476
AVP arginine vasopressin 0.249302
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.247492
FBRS fibrosin 0.24713
TNC tenascin C 0.244962
NGF nerve growth factor (beta polypeptide) 0.243519
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.242797
GFAP glial fibrillary acidic protein 0.241356
EFS embryonal Fyn-associated substrate 0.238478
CREB3L1 cAMP responsive element binding protein 3-like 1 0.238119
DOK5 docking protein 5 0.237401
ERF Ets2 repressor factor 0.237042
CD4 CD4 molecule 0.236324
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.236324
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.234891
SEC23A Sec23 homolog A (S. cerevisiae) 0.233459
TNF tumor necrosis factor 0.232386
PARP15 poly (ADP-ribose) polymerase family, member 15 0.229532
CD22 CD22 molecule 0.227041
SCG5 secretogranin V 0.227041
DEFB104B defensin, beta 104B 0.22385
BCAP31 B-cell receptor-associated protein 31 0.222436
CD7 CD7 molecule 0.220673
PNMT phenylethanolamine N-methyltransferase 0.218563
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.217511
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.217511
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.21681
FKBP2 FK506 binding protein 2, 13kDa 0.21646
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.215063
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.214714
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.214714
CPE carboxypeptidase E 0.211933
CDK20 cyclin-dependent kinase 20 0.21124
PMM1 phosphomannomutase 1 0.210549
LBR lamin B receptor 0.209169
PENK proenkephalin 0.208481
CP ceruloplasmin (ferroxidase) 0.207108
LUM lumican 0.206082
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.203022
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.202346
GPHA2 glycoprotein hormone alpha 2 0.200663
RHO rhodopsin 0.200328
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.199325
MDH1 malate dehydrogenase 1, NAD (soluble) 0.198991
ATL3 atlastin GTPase 3 0.198658
SOS1 son of sevenless homolog 1 (Drosophila) 0.198325
SORD sorbitol dehydrogenase 0.197662
REG3A regenerating islet-derived 3 alpha 0.197662
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.195025
HAND1 heart and neural crest derivatives expressed 1 0.193394
MAP2 microtubule-associated protein 2 0.191777
LEP leptin 0.190175
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 0.188905
VCAM1 vascular cell adhesion molecule 1 0.186708
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.185777
LEPR leptin receptor 0.18516
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.183631
GPX8 glutathione peroxidase 8 (putative) 0.182723
LCT lactase 0.182723
DOK4 docking protein 4 0.181823
PARP9 poly (ADP-ribose) polymerase family, member 9 0.181227
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.18093
AACS acetoacetyl-CoA synthetase 0.178588
CCDC34 coiled-coil domain containing 34 0.178299
CD37 CD37 molecule 0.177439
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.177439
LEMD3 LEM domain containing 3 0.17687
SRP9 signal recognition particle 9kDa 0.176587
SRP9P1 signal recognition particle 9 pseudogene 1 0.176587
LRP2 low density lipoprotein receptor-related protein 2 0.175466
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.175466
B2M beta-2-microglobulin 0.175188
TNMD tenomodulin 0.173814
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.172468
HAS1 hyaluronan synthase 1 0.172468
CABP4 calcium binding protein 4 0.17141
PGRMC1 progesterone receptor membrane component 1 0.169859
MYH11 myosin, heavy chain 11, smooth muscle 0.16935
CALB1 calbindin 1, 28kDa 0.168598
CTSK cathepsin K 0.166167
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 0.166167
G6PD glucose-6-phosphate dehydrogenase 0.165932
GIF gastric intrinsic factor (vitamin B synthesis) 0.165231
EPYC epiphycan 0.165
CALD1 caldesmon 1 0.163641
CDON cell adhesion associated, oncogene regulated 0.1632
CSTB cystatin B (stefin B) 0.16298
ESX1 ESX homeobox 1 0.16298
FSD1 fibronectin type III and SPRY domain containing 1 0.162763
KRTCAP2 keratinocyte associated protein 2 0.162546
EXOC5 exocyst complex component 5 0.161484
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.160658
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.159658
STARD5 StAR-related lipid transfer (START) domain containing 5 0.159658
GP2 glycoprotein 2 (zymogen granule membrane) 0.159074
TSPAN16 tetraspanin 16 0.158882
IL31RA interleukin 31 receptor A 0.158502
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.158502
CSN2 casein beta 0.158129
PRDX4 peroxiredoxin 4 0.157943
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.157218