rifabutin-4527 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the rifabutin-4527 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BMP4 bone morphogenetic protein 4
C2ORF27A chromosome 2 open reading frame 27A
CAPN3 calpain 3, (p94)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP68 centrosomal protein 68kDa
CHN2 chimerin 2
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLCN7 chloride channel, voltage-sensitive 7
CLDN1 claudin 1
CLDN8 claudin 8
COBL cordon-bleu WH2 repeat protein
COL21A1 collagen, type XXI, alpha 1
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
CYTH4 cytohesin 4
DNAAF1 dynein, axonemal, assembly factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL4 dihydropyrimidinase-like 4
DUSP10 dual specificity phosphatase 10
ELOVL4 ELOVL fatty acid elongase 4
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EREG epiregulin
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM110B family with sequence similarity 110, member B
FAM134B family with sequence similarity 134, member B
FAM69A family with sequence similarity 69, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GK glycerol kinase
GMPR guanosine monophosphate reductase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRAMD1C GRAM domain containing 1C
GRK5 G protein-coupled receptor kinase 5
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H2AL histone cluster 1, H2al
HOXA1 homeobox A1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LOC100130741 uncharacterized LOC100130741
LPPR4 lipid phosphate phosphatase-related protein type 4
MAK male germ cell-associated kinase
MAL mal, T-cell differentiation protein
MAPT microtubule-associated protein tau
MERTK MER proto-oncogene, tyrosine kinase
MLYCD malonyl-CoA decarboxylase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAIP2B poly(A) binding protein interacting protein 2B
PCDH17 protocadherin 17
PCDH7 protocadherin 7
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAG1 pleiomorphic adenoma gene 1
PLSCR4 phospholipid scramblase 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRPH peripherin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RLN1 relaxin 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF24 ring finger protein 24
RRAGD Ras-related GTP binding D
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCEL sciellin
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SHOX2 short stature homeobox 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SOSTDC1 sclerostin domain containing 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STC1 stanniocalcin 1
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
TGFBR3 transforming growth factor, beta receptor III
TNIK TRAF2 and NCK interacting kinase
TUBB2B tubulin, beta 2B class IIb
VCAN versican

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRG6 adhesion G protein-coupled receptor G6
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP19 Rho GTPase activating protein 19
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
C9ORF91 chromosome 9 open reading frame 91
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CASD1 CAS1 domain containing 1
CCDC94 coiled-coil domain containing 94
CENPT centromere protein T
CNTNAP1 contactin associated protein 1
CORT cortistatin
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPNE7 copine VII
CTCF CCCTC-binding factor (zinc finger protein)
CTPS1 CTP synthase 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYTH2 cytohesin 2
DEAF1 DEAF1 transcription factor
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GPATCH3 G patch domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
GTF2I general transcription factor IIi
HAS2 hyaluronan synthase 2
HDAC7 histone deacetylase 7
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL17RA interleukin 17 receptor A
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KAT7 K(lysine) acetyltransferase 7
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMNB1 lamin B1
LMNB2 lamin B2
LRRK1 leucine-rich repeat kinase 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEPCE methylphosphate capping enzyme
MKS1 Meckel syndrome, type 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MX1 MX dynamin-like GTPase 1
NDP Norrie disease (pseudoglioma)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NMI N-myc (and STAT) interactor
NUPR1 nuclear protein, transcriptional regulator, 1
PALMD palmdelphin
PARP3 poly (ADP-ribose) polymerase family, member 3
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RBL1 retinoblastoma-like 1
RBM23 RNA binding motif protein 23
RBM4B RNA binding motif protein 4B
RIN1 Ras and Rab interactor 1
RIN2 Ras and Rab interactor 2
RRAGB Ras-related GTP binding B
SDCCAG3 serologically defined colon cancer antigen 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SMYD5 SMYD family member 5
SPAG7 sperm associated antigen 7
STK16 serine/threonine kinase 16
STRN4 striatin, calmodulin binding protein 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TARBP2 TAR (HIV-1) RNA binding protein 2
TENM4 teneurin transmembrane protein 4
TMEM254 transmembrane protein 254
TRIM16 tripartite motif containing 16
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UBTF upstream binding transcription factor, RNA polymerase I
UBXN8 UBX domain protein 8
UNKL unkempt family zinc finger-like
USP21 ubiquitin specific peptidase 21
VWA9 von Willebrand factor A domain containing 9
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WBSCR16 Williams-Beuren syndrome chromosome region 16
ZBED1 zinc finger, BED-type containing 1
ZNF197 zinc finger protein 197
ZNF282 zinc finger protein 282
ZNF33B zinc finger protein 33B
ZNF358 zinc finger protein 358
ZNF532 zinc finger protein 532
ZNF787 zinc finger protein 787