response to drug Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. (Gene Ontology, GO_0042493)
External Link http://amigo.geneontology.org/amigo/term/GO:0042493
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Genes

350 genes participating in the response to drug biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AACS acetoacetyl-CoA synthetase
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACACB acetyl-CoA carboxylase beta
ACER2 alkaline ceramidase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTC1 actin, alpha, cardiac muscle 1
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADCY1 adenylate cyclase 1 (brain)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
ADSSL1 adenylosuccinate synthase like 1
AIM2 absent in melanoma 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMH anti-Mullerian hormone
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANXA1 annexin A1
AOC1 amine oxidase, copper containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOC3 apolipoprotein C-III
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
ASS1 argininosuccinate synthase 1
ATG5 autophagy related 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
ATR ATR serine/threonine kinase
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BCAR3 breast cancer anti-estrogen resistance 3
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BGLAP bone gamma-carboxyglutamate (gla) protein
BLMH bleomycin hydrolase
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CA4 carbonic anhydrase IV
CA9 carbonic anhydrase IX
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALR calreticulin
CARD9 caspase recruitment domain family, member 9
CCL2 chemokine (C-C motif) ligand 2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNO cyclin O
CD38 CD38 molecule
CD69 CD69 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPF centromere protein F, 350/400kDa
CERS1 ceramide synthase 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHUK conserved helix-loop-helix ubiquitous kinase
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1A carnitine palmitoyltransferase 1A (liver)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CSAG3 CSAG family, member 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTPS1 CTP synthase 1
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAD1 defender against cell death 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHODH dihydroorotate dehydrogenase (quinone)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPEP1 dipeptidase 1 (renal)
DPYSL2 dihydropyrimidinase-like 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP6 dual specificity phosphatase 6
DVL3 dishevelled segment polarity protein 3
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EI24 etoposide induced 2.4
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EMX1 empty spiracles homeobox 1
EMX2 empty spiracles homeobox 2
ENG endoglin
ENO3 enolase 3 (beta, muscle)
FABP3 fatty acid binding protein 3, muscle and heart
FBP1 fructose-1,6-bisphosphatase 1
FECH ferrochelatase
FGF8 fibroblast growth factor 8 (androgen-induced)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD1 frizzled class receptor 1
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GIP gastric inhibitory polypeptide
GMPS guanine monphosphate synthase
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GNPAT glyceronephosphate O-acyltransferase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSK3B glycogen synthase kinase 3 beta
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL10 interleukin 10
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
INHBA inhibin, beta A
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LOX lysyl oxidase
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
LYST lysosomal trafficking regulator
MAOB monoamine oxidase B
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK9 mitogen-activated protein kinase 9
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MGMT O-6-methylguanine-DNA methyltransferase
MGST1 microsomal glutathione S-transferase 1
MMP7 matrix metallopeptidase 7
MT2A metallothionein 2A
MT3 metallothionein 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCF2 neutrophil cytosolic factor 2
NCKAP1L NCK-associated protein 1-like
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NEUROD1 neuronal differentiation 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NGF nerve growth factor (beta polypeptide)
NKX3-1 NK3 homeobox 1
NKX6-1 NK6 homeobox 1
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NPC1L1 NPC1-like 1
NPFF neuropeptide FF-amide peptide precursor
NPPC natriuretic peptide C
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OGG1 8-oxoguanine DNA glycosylase
OTC ornithine carbamoyltransferase
OXCT1 3-oxoacid CoA transferase 1
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAPD7 PAP associated domain containing 7
PARP4 poly (ADP-ribose) polymerase family, member 4
PAX4 paired box 4
PAX6 paired box 6
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDX1 pancreatic and duodenal homeobox 1
PFAS phosphoribosylformylglycinamidine synthase
PGF placental growth factor
PLIN2 perilipin 2
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNP purine nucleoside phosphorylase
POR P450 (cytochrome) oxidoreductase
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPAT phosphoribosyl pyrophosphate amidotransferase
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPOX protoporphyrinogen oxidase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTK2B protein tyrosine kinase 2 beta
PTPRM protein tyrosine phosphatase, receptor type, M
QDPR quinoid dihydropteridine reductase
RAB6C RAB6C, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RAP2A RAP2A, member of RAS oncogene family
RBM22 RNA binding motif protein 22
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
REST RE1-silencing transcription factor
RET ret proto-oncogene
RNF149 ring finger protein 149
RPH3AL rabphilin 3A-like (without C2 domains)
RPN2 ribophorin II
RPP21 ribonuclease P/MRP 21kDa subunit
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SLAMF8 SLAM family member 8
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD1 SMAD family member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPINK4 serine peptidase inhibitor, Kazal type 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SREBF1 sterol regulatory element binding transcription factor 1
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP19 signal recognition particle 19kDa
SRP54 signal recognition particle 54kDa
SRP68 signal recognition particle 68kDa
SRP72 signal recognition particle 72kDa
SRR serine racemase
SS18 synovial sarcoma translocation, chromosome 18
SST somatostatin
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBXA2R thromboxane A2 receptor
TCF3 transcription factor 3
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TH tyrosine hydroxylase
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP4 TIMP metallopeptidase inhibitor 4
TJP1 tight junction protein 1
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TSPO translocator protein (18kDa)
TXN2 thioredoxin 2
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
UBE2B ubiquitin-conjugating enzyme E2B
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UMPS uridine monophosphate synthetase
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP47 ubiquitin specific peptidase 47
UTS2 urotensin 2
UTS2R urotensin 2 receptor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
WFDC1 WAP four-disulfide core domain 1
XBP1 X-box binding protein 1
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta