rationale Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

142 genes co-occuring with the biological term rationale in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APP amyloid beta (A4) precursor protein
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTLA B and T lymphocyte associated
CA9 carbonic anhydrase IX
CCDC54 coiled-coil domain containing 54
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1B CD1b molecule
CD274 CD274 molecule
CD38 CD38 molecule
CD40LG CD40 ligand
CD52 CD52 molecule
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETP cholesteryl ester transfer protein, plasma
CLDN4 claudin 4
COMT catechol-O-methyltransferase
CRH corticotropin releasing hormone
CST2 cystatin SA
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDR2 discoidin domain receptor tyrosine kinase 2
DIABLO diablo, IAP-binding mitochondrial protein
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
ENG endoglin
EPHA2 EPH receptor A2
ETFA electron-transfer-flavoprotein, alpha polypeptide
ETFB electron-transfer-flavoprotein, beta polypeptide
ETV6 ets variant 6
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FGFR4 fibroblast growth factor receptor 4
FGL2 fibrinogen-like 2
FKBP8 FK506 binding protein 8, 38kDa
FOXM1 forkhead box M1
GATA4 GATA binding protein 4
GEMIN2 gem (nuclear organelle) associated protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHSR growth hormone secretagogue receptor
GNRHR gonadotropin-releasing hormone receptor
GSTP1 glutathione S-transferase pi 1
HDAC2 histone deacetylase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-G major histocompatibility complex, class I, G
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
HTT huntingtin
IFT140 intraflagellar transport 140
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
INSR insulin receptor
KAT2B K(lysine) acetyltransferase 2B
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
MALT1 MALT1 paracaspase
MCL1 myeloid cell leukemia 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR103A1 microRNA 103a-1
MIR103A2 microRNA 103a-2
MIR125B1 microRNA 125b-1
MIR199A1 microRNA 199a-1
MIR21 microRNA 21
MIR29A microRNA 29a
MIR30B microRNA 30b
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NF2 neurofibromin 2 (merlin)
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NT5C3A 5'-nucleotidase, cytosolic IIIA
OSMR oncostatin M receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDCD1 programmed cell death 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIP prolactin-induced protein
PKLR pyruvate kinase, liver and RBC
PML promyelocytic leukemia
PPARD peroxisome proliferator-activated receptor delta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PROM1 prominin 1
PSEN1 presenilin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTEN phosphatase and tensin homolog
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RET ret proto-oncogene
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RUNX1 runt-related transcription factor 1
S1PR1 sphingosine-1-phosphate receptor 1
SHH sonic hedgehog
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMN2 survival of motor neuron 2, centromeric
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TGFB1 transforming growth factor, beta 1
THRB thyroid hormone receptor, beta
THRSP thyroid hormone responsive
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPO translocator protein (18kDa)