ramipril-6150 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the ramipril-6150 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACOT11 acyl-CoA thioesterase 11
ADGRL3 adhesion G protein-coupled receptor L3
ADORA1 adenosine A1 receptor
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANGPT4 angiopoietin 4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATN1 atrophin 1
BBS9 Bardet-Biedl syndrome 9
BMP7 bone morphogenetic protein 7
C19ORF26 chromosome 19 open reading frame 26
CD226 CD226 molecule
CLCN4 chloride channel, voltage-sensitive 4
CSRP2 cysteine and glycine-rich protein 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCR6 chemokine (C-X-C motif) receptor 6
DHRS12 dehydrogenase/reductase (SDR family) member 12
DLK2 delta-like 2 homolog (Drosophila)
DSCAM Down syndrome cell adhesion molecule
EFCAB6 EF-hand calcium binding domain 6
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EXTL3 exostosin-like glycosyltransferase 3
FADS3 fatty acid desaturase 3
FDXR ferredoxin reductase
FGF22 fibroblast growth factor 22
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSHB follicle stimulating hormone, beta polypeptide
FXYD2 FXYD domain containing ion transport regulator 2
GAST gastrin
GLRA1 glycine receptor, alpha 1
GPR19 G protein-coupled receptor 19
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
IDS iduronate 2-sulfatase
IFNA16 interferon, alpha 16
IL11 interleukin 11
IL22 interleukin 22
ING4 inhibitor of growth family, member 4
INO80B INO80 complex subunit B
IZUMO4 IZUMO family member 4
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF1C kinesin family member 1C
KLF4 Kruppel-like factor 4 (gut)
KRTAP2-4 keratin associated protein 2-4
LCAT lecithin-cholesterol acyltransferase
MAP7 microtubule-associated protein 7
MASP2 mannan-binding lectin serine peptidase 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIA melanoma inhibitory activity
MISP mitotic spindle positioning
MPPE1 metallophosphoesterase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTNG1 netrin G1
ONECUT2 one cut homeobox 2
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PCNXL2 pecanex-like 2 (Drosophila)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE10A phosphodiesterase 10A
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER3 period circadian clock 3
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPT2 palmitoyl-protein thioesterase 2
PRB1 proline-rich protein BstNI subfamily 1
RAB40C RAB40C, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RBFA ribosome binding factor A (putative)
SAMD4A sterile alpha motif domain containing 4A
SCIN scinderin
SCRN3 secernin 3
SETD1A SET domain containing 1A
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOX4 SRY (sex determining region Y)-box 4
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TAPT1 transmembrane anterior posterior transformation 1
TBXA2R thromboxane A2 receptor
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TMPRSS6 transmembrane protease, serine 6
TRD T cell receptor delta locus
TRPM3 transient receptor potential cation channel, subfamily M, member 3
WWC1 WW and C2 domain containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF219 zinc finger protein 219

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
CBR3 carbonyl reductase 3
CD70 CD70 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHM choroideremia (Rab escort protein 1)
CHML choroideremia-like (Rab escort protein 2)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLEC2D C-type lectin domain family 2, member D
CLEC4E C-type lectin domain family 4, member E
CRABP2 cellular retinoic acid binding protein 2
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNMBP dynamin binding protein
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EYA3 EYA transcriptional coactivator and phosphatase 3
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GIPC1 GIPC PDZ domain containing family, member 1
GPC3 glypican 3
GPR20 G protein-coupled receptor 20
GPR21 G protein-coupled receptor 21
GSPT2 G1 to S phase transition 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H3G histone cluster 1, H3g
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HOXA1 homeobox A1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT81 intraflagellar transport 81
INO80D INO80 complex subunit D
IRX5 iroquois homeobox 5
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIAA0556 KIAA0556
KIAA1024 KIAA1024
KLF3 Kruppel-like factor 3 (basic)
LOC100287590 uncharacterized LOC100287590
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTC4S leukotriene C4 synthase
MBOAT2 membrane bound O-acyltransferase domain containing 2
MTERF1 mitochondrial transcription termination factor 1
MVD mevalonate (diphospho) decarboxylase
NDE1 nudE neurodevelopment protein 1
NSUN6 NOP2/Sun domain family, member 6
OMG oligodendrocyte myelin glycoprotein
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAQR6 progestin and adipoQ receptor family member VI
PCDHGB5 protocadherin gamma subfamily B, 5
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIPOX pipecolic acid oxidase
PLCD1 phospholipase C, delta 1
POLL polymerase (DNA directed), lambda
PORCN porcupine homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
RFXAP regulatory factor X-associated protein
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBX19 T-box 19
TEX40 testis expressed 40
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM140 transmembrane protein 140
TMEM212 transmembrane protein 212
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNS2 tensin 2
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSPAN13 tetraspanin 13
TSPAN2 tetraspanin 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UBQLN4 ubiquilin 4
USP19 ubiquitin specific peptidase 19
USP36 ubiquitin specific peptidase 36
WASF3 WAS protein family, member 3
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
ZBTB22 zinc finger and BTB domain containing 22
ZBTB6 zinc finger and BTB domain containing 6
ZC4H2 zinc finger, C4H2 domain containing
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZHX2 zinc fingers and homeoboxes 2
ZNF32 zinc finger protein 32
ZNF37BP zinc finger protein 37B, pseudogene
ZNF552 zinc finger protein 552