ramipril-3572 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the ramipril-3572 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADAM11 ADAM metallopeptidase domain 11
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP35 Rho GTPase activating protein 35
BLVRA biliverdin reductase A
C6ORF10 chromosome 6 open reading frame 10
CALD1 caldesmon 1
CAV2 caveolin 2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAT choline O-acetyltransferase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRTC1 CREB regulated transcription coactivator 1
CRYM crystallin, mu
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DOCK6 dedicator of cytokinesis 6
DUSP6 dual specificity phosphatase 6
EFNA3 ephrin-A3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV5 ets variant 5
FBXO21 F-box protein 21
FGF18 fibroblast growth factor 18
FKBP10 FK506 binding protein 10, 65 kDa
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAS1 growth arrest-specific 1
GJA4 gap junction protein, alpha 4, 37kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR137 G protein-coupled receptor 137
GPR153 G protein-coupled receptor 153
GPR68 G protein-coupled receptor 68
GSPT1 G1 to S phase transition 1
GTDC1 glycosyltransferase-like domain containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIPK2 homeodomain interacting protein kinase 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1B HNF1 homeobox B
HRH2 histamine receptor H2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGFBP3 insulin-like growth factor binding protein 3
ING1 inhibitor of growth family, member 1
IRF4 interferon regulatory factor 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JPH3 junctophilin 3
KDM4B lysine (K)-specific demethylase 4B
KLF8 Kruppel-like factor 8
KLHL29 kelch-like family member 29
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAMC2 laminin, gamma 2
LHB luteinizing hormone beta polypeptide
LMTK2 lemur tyrosine kinase 2
LPL lipoprotein lipase
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAOB monoamine oxidase B
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYOF myoferlin
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOP14-AS1 NOP14 antisense RNA 1
OPCML opioid binding protein/cell adhesion molecule-like
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPRM1 opioid receptor, mu 1
PCDHB1 protocadherin beta 1
PENK proenkephalin
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
POFUT1 protein O-fucosyltransferase 1
PORCN porcupine homolog (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RHBDD3 rhomboid domain containing 3
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
RPH3A rabphilin 3A
SEC23IP SEC23 interacting protein
SENP7 SUMO1/sentrin specific peptidase 7
SIDT2 SID1 transmembrane family, member 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35E2 solute carrier family 35, member E2
SPINK1 serine peptidase inhibitor, Kazal type 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TENM1 teneurin transmembrane protein 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM8B transmembrane protein 8B
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM36 tripartite motif containing 36
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USP46 ubiquitin specific peptidase 46
VGF VGF nerve growth factor inducible
WDTC1 WD and tetratricopeptide repeats 1
WRAP53 WD repeat containing, antisense to TP53
ZNF236 zinc finger protein 236
ZNF79 zinc finger protein 79
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADGRE5 adhesion G protein-coupled receptor E5
ALPK1 alpha-kinase 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP10D ATPase, class V, type 10D
BCL9 B-cell CLL/lymphoma 9
C19ORF40 chromosome 19 open reading frame 40
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN15 calpain 15
CCNK cyclin K
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CFAP45 cilia and flagella associated protein 45
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CNGB3 cyclic nucleotide gated channel beta 3
CRLF1 cytokine receptor-like factor 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
ERN2 endoplasmic reticulum to nucleus signaling 2
FKBP5 FK506 binding protein 5
FLCN folliculin
FUZ fuzzy planar cell polarity protein
GALT galactose-1-phosphate uridylyltransferase
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR157 G protein-coupled receptor 157
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H4D histone cluster 1, H4d
HOXC10 homeobox C10
HOXC8 homeobox C8
INCENP inner centromere protein antigens 135/155kDa
INPP1 inositol polyphosphate-1-phosphatase
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNK15 potassium channel, two pore domain subfamily K, member 15
KDM5C lysine (K)-specific demethylase 5C
KLHL36 kelch-like family member 36
KREMEN2 kringle containing transmembrane protein 2
LAMA5 laminin, alpha 5
LINC00597 long intergenic non-protein coding RNA 597
LOC257152 uncharacterized LOC257152
LRP2 low density lipoprotein receptor-related protein 2
LRRC8E leucine rich repeat containing 8 family, member E
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MATK megakaryocyte-associated tyrosine kinase
MITF microphthalmia-associated transcription factor
MRPL41 mitochondrial ribosomal protein L41
MTSS1L metastasis suppressor 1-like
MYO1E myosin IE
NOL12 nucleolar protein 12
NPTX1 neuronal pentraxin I
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAQR6 progestin and adipoQ receptor family member VI
PCDHA9 protocadherin alpha 9
PCDHB3 protocadherin beta 3
PCDHGA10 protocadherin gamma subfamily A, 10
PLA2G3 phospholipase A2, group III
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RPL10L ribosomal protein L10-like
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SETD1A SET domain containing 1A
SLC12A8 solute carrier family 12, member 8
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SSBP3 single stranded DNA binding protein 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRD1 tudor domain containing 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC7 transmembrane channel-like 7
TMEM121 transmembrane protein 121
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF137P zinc finger protein 137, pseudogene
ZNF428 zinc finger protein 428
ZNF652 zinc finger protein 652
ZNF701 zinc finger protein 701
ZNF91 zinc finger protein 91