ramifenazone-2534 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ramifenazone-2534 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP44 Rho GTPase activating protein 44
ART1 ADP-ribosyltransferase 1
ATP9B ATPase, class II, type 9B
BMP1 bone morphogenetic protein 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CD22 CD22 molecule
CD28 CD28 molecule
CDC14A cell division cycle 14A
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
COL15A1 collagen, type XV, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CRYGD crystallin, gamma D
CUL2 cullin 2
CUL7 cullin 7
CYHR1 cysteine/histidine-rich 1
DFNA5 deafness, autosomal dominant 5
DMWD dystrophia myotonica, WD repeat containing
DNM3 dynamin 3
DNMBP dynamin binding protein
DTX2 deltex 2, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
ESR2 estrogen receptor 2 (ER beta)
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DMA major histocompatibility complex, class II, DM alpha
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLF3 Kruppel-like factor 3 (basic)
KRIT1 KRIT1, ankyrin repeat containing
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00597 long intergenic non-protein coding RNA 597
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP6D1 MAP6 domain containing 1
MEG3 maternally expressed 3 (non-protein coding)
MTSS1 metastasis suppressor 1
MXD4 MAX dimerization protein 4
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRP1 neuropilin 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARP16 poly (ADP-ribose) polymerase family, member 16
PCLO piccolo presynaptic cytomatrix protein
PHACTR1 phosphatase and actin regulator 1
PHF8 PHD finger protein 8
PID1 phosphotyrosine interaction domain containing 1
PLK2 polo-like kinase 2
PLK3 polo-like kinase 3
PLK4 polo-like kinase 4
PLS3 plastin 3
POFUT1 protein O-fucosyltransferase 1
PORCN porcupine homolog (Drosophila)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP4R4 protein phosphatase 4, regulatory subunit 4
PPP5C protein phosphatase 5, catalytic subunit
PVR poliovirus receptor
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAP2B RAP2B, member of RAS oncogene family
RASAL2 RAS protein activator like 2
RB1 retinoblastoma 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RNGTT RNA guanylyltransferase and 5'-phosphatase
SAA4 serum amyloid A4, constitutive
SALL2 spalt-like transcription factor 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SOCS3 suppressor of cytokine signaling 3
SPAG1 sperm associated antigen 1
SPAG8 sperm associated antigen 8
SUMO1 small ubiquitin-like modifier 1
TACR1 tachykinin receptor 1
TADA3 transcriptional adaptor 3
TBRG4 transforming growth factor beta regulator 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD3 TEA domain family member 3
TGFB1 transforming growth factor, beta 1
TM4SF5 transmembrane 4 L six family member 5
TMEM63A transmembrane protein 63A
TMOD1 tropomodulin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM36 tripartite motif containing 36
TRPS1 trichorhinophalangeal syndrome I
TYMP thymidine phosphorylase
TYRO3 TYRO3 protein tyrosine kinase
ZFP64 ZFP64 zinc finger protein
ZNF219 zinc finger protein 219

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADORA3 adenosine A3 receptor
ALS2CL ALS2 C-terminal like
AMH anti-Mullerian hormone
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
AXIN1 axin 1
C1ORF56 chromosome 1 open reading frame 56
CBX8 chromobox homolog 8
CCDC57 coiled-coil domain containing 57
CCDC92 coiled-coil domain containing 92
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD300C CD300c molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDHR2 cadherin-related family member 2
CPTP ceramide-1-phosphate transfer protein
CRABP2 cellular retinoic acid binding protein 2
CRYGC crystallin, gamma C
CST1 cystatin SN
CTSO cathepsin O
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDN dendrin
DKFZP434L187 uncharacterized LOC26082
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSPP dentin sialophosphoprotein
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM86C1 family with sequence similarity 86, member C1
FBXO40 F-box protein 40
FRMPD1 FERM and PDZ domain containing 1
GIPR gastric inhibitory polypeptide receptor
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
HAMP hepcidin antimicrobial peptide
HCG4 HLA complex group 4 (non-protein coding)
HIST1H2BI histone cluster 1, H2bi
HIST1H3B histone cluster 1, H3b
HOXD11 homeobox D11
HP haptoglobin
HPR haptoglobin-related protein
HYAL4 hyaluronoglucosaminidase 4
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP4 insulin-like growth factor binding protein 4
INO80D INO80 complex subunit D
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT20 keratin 20, type I
KRT81 keratin 81, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LOC257152 uncharacterized LOC257152
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MGP matrix Gla protein
MKRN3 makorin ring finger protein 3
MUC3A mucin 3A, cell surface associated
MYO1E myosin IE
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NINJ2 ninjurin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PBOV1 prostate and breast cancer overexpressed 1
PICK1 protein interacting with PRKCA 1
PIPOX pipecolic acid oxidase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCD1 phospholipase C, delta 1
POU5F1B POU class 5 homeobox 1B
PPT2 palmitoyl-protein thioesterase 2
PRO2964 uncharacterized protein PRO2964
PROL1 proline rich, lacrimal 1
RAPSN receptor-associated protein of the synapse
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN2 Ras and Rab interactor 2
RNF39 ring finger protein 39
SLC16A6 solute carrier family 16, member 6
SLC35F6 solute carrier family 35, member F6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SPEF1 sperm flagellar 1
SPRR2B small proline-rich protein 2B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAS2R10 taste receptor, type 2, member 10
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM209 transmembrane protein 209
TNS2 tensin 2
ULBP2 UL16 binding protein 2
UPB1 ureidopropionase, beta
USB1 U6 snRNA biogenesis 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
ZNF132 zinc finger protein 132
ZNF41 zinc finger protein 41
ZNF574 zinc finger protein 574
ZNF768 zinc finger protein 768