raloxifene-388 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the raloxifene-388 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM20 ADAM metallopeptidase domain 20
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AR androgen receptor
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARSF arylsulfatase F
ASCL1 achaete-scute family bHLH transcription factor 1
ATOX1 antioxidant 1 copper chaperone
AVIL advillin
BAIAP2 BAI1-associated protein 2
BATF basic leucine zipper transcription factor, ATF-like
BICD1 bicaudal D homolog 1 (Drosophila)
BTN2A1 butyrophilin, subfamily 2, member A1
C8B complement component 8, beta polypeptide
CAMKV CaM kinase-like vesicle-associated
CDC14A cell division cycle 14A
CDKN2A cyclin-dependent kinase inhibitor 2A
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLIC4 chloride intracellular channel 4
CSN2 casein beta
CUX1 cut-like homeobox 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DOCK10 dedicator of cytokinesis 10
EDA2R ectodysplasin A2 receptor
EPHB1 EPH receptor B1
ETV5 ets variant 5
FBRS fibrosin
GAST gastrin
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GM2A GM2 ganglioside activator
GPKOW G patch domain and KOW motifs
GRM7 glutamate receptor, metabotropic 7
GYPB glycophorin B (MNS blood group)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H2AC histone cluster 1, H2ac
HIST1H2BI histone cluster 1, H2bi
HK2 hexokinase 2
HRASLS2 HRAS-like suppressor 2
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA1 HtrA serine peptidase 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KAZN kazrin, periplakin interacting protein
KDM8 lysine (K)-specific demethylase 8
KLHL25 kelch-like family member 25
KLK10 kallikrein-related peptidase 10
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT75 keratin 75, type II
LCN2 lipocalin 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00216 long intergenic non-protein coding RNA 216
LMO3 LIM domain only 3 (rhombotin-like 2)
LRMP lymphoid-restricted membrane protein
LRRC48 leucine rich repeat containing 48
LUC7L LUC7-like (S. cerevisiae)
MLH3 mutL homolog 3
MOB3B MOB kinase activator 3B
MSH3 mutS homolog 3
MTERF4 mitochondrial transcription termination factor 4
MVP major vault protein
NNAT neuronatin
NRG1 neuregulin 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OCRL oculocerebrorenal syndrome of Lowe
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE4DIP phosphodiesterase 4D interacting protein
PDE8A phosphodiesterase 8A
PGAP2 post-GPI attachment to proteins 2
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
POU5F1B POU class 5 homeobox 1B
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRB1 proline-rich protein BstNI subfamily 1
PRPF18 pre-mRNA processing factor 18
PRY PTPN13-like, Y-linked
PTCD1 pentatricopeptide repeat domain 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRA protein tyrosine phosphatase, receptor type, A
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRT3 sirtuin 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMOX spermine oxidase
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
TCF3 transcription factor 3
TMEM161A transmembrane protein 161A
TMF1 TATA element modulatory factor 1
TMPRSS6 transmembrane protease, serine 6
TNK1 tyrosine kinase, non-receptor, 1
TPSAB1 tryptase alpha/beta 1
TUBA4B tubulin, alpha 4b
VAC14 Vac14 homolog (S. cerevisiae)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF592 zinc finger protein 592

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADGRA3 adhesion G protein-coupled receptor A3
ASAP1-IT1 ASAP1 intronic transcript 1
BCL7B B-cell CLL/lymphoma 7B
BHMT betaine--homocysteine S-methyltransferase
BICC1 BicC family RNA binding protein 1
BTBD18 BTB (POZ) domain containing 18
CA9 carbonic anhydrase IX
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CARD9 caspase recruitment domain family, member 9
CCDC53 coiled-coil domain containing 53
CD68 CD68 molecule
CDC37 cell division cycle 37
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CLEC2B C-type lectin domain family 2, member B
CNGB3 cyclic nucleotide gated channel beta 3
COG7 component of oligomeric golgi complex 7
CRYBB2P1 crystallin, beta B2 pseudogene 1
CST4 cystatin S
DGAT1 diacylglycerol O-acyltransferase 1
DSG2 desmoglein 2
FBXL15 F-box and leucine-rich repeat protein 15
FSTL4 follistatin-like 4
GAGE3 G antigen 3
GUSBP3 glucuronidase, beta pseudogene 3
HCG9 HLA complex group 9 (non-protein coding)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMX1 H6 family homeobox 1
HOOK2 hook microtubule-tethering protein 2
HYAL1 hyaluronoglucosaminidase 1
IL15RA interleukin 15 receptor, alpha
IL22 interleukin 22
IQCG IQ motif containing G
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
JMJD4 jumonji domain containing 4
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLC2 kinesin light chain 2
KLF15 Kruppel-like factor 15
KLHL3 kelch-like family member 3
KRT23 keratin 23, type I
LHB luteinizing hormone beta polypeptide
LIAS lipoic acid synthetase
LMAN2L lectin, mannose-binding 2-like
MBNL3 muscleblind-like splicing regulator 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFAP2 microfibrillar-associated protein 2
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCS1 neuronal calcium sensor 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
OMG oligodendrocyte myelin glycoprotein
OVGP1 oviductal glycoprotein 1, 120kDa
OVOL1 ovo-like zinc finger 1
PCTP phosphatidylcholine transfer protein
PF4 platelet factor 4
PISD phosphatidylserine decarboxylase
PRR11 proline rich 11
PRR15L proline rich 15-like
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QTRT1 queuine tRNA-ribosyltransferase 1
RABL3 RAB, member of RAS oncogene family-like 3
RABL6 RAB, member RAS oncogene family-like 6
RASIP1 Ras interacting protein 1
RCAN2 regulator of calcineurin 2
RDH8 retinol dehydrogenase 8 (all-trans)
RHBDD3 rhomboid domain containing 3
RLBP1 retinaldehyde binding protein 1
RNASE3 ribonuclease, RNase A family, 3
SETMAR SET domain and mariner transposase fusion gene
SHPK sedoheptulokinase
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLIT2 slit homolog 2 (Drosophila)
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SPON2 spondin 2, extracellular matrix protein
SPP2 secreted phosphoprotein 2, 24kDa
TCN2 transcobalamin II
TCP10 t-complex 10
TESC tescalcin
THBS3 thrombospondin 3
TMEM39B transmembrane protein 39B
TMPRSS5 transmembrane protease, serine 5
TMSB15B thymosin beta 15B
TPSD1 tryptase delta 1
TPSG1 tryptase gamma 1
TRAPPC12 trafficking protein particle complex 12
TSPO2 translocator protein 2
TTC26 tetratricopeptide repeat domain 26
TUFT1 tuftelin 1
WDR46 WD repeat domain 46
WDR62 WD repeat domain 62
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZFP30 ZFP30 zinc finger protein
ZNF211 zinc finger protein 211
ZNF271P zinc finger protein 271, pseudogene