pyrvinium-5439 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pyrvinium-5439 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACTA2 actin, alpha 2, smooth muscle, aorta
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA1 annexin A1
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BBC3 BCL2 binding component 3
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEL carboxyl ester lipase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CREM cAMP responsive element modulator
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GPR87 G protein-coupled receptor 87
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HDAC5 histone deacetylase 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICA1 islet cell autoantigen 1, 69kDa
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL21R interleukin 21 receptor
INHBE inhibin, beta E
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDB3 LIM domain binding 3
LIF leukemia inhibitory factor
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MT1F metallothionein 1F
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NHLH2 nescient helix loop helix 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OVGP1 oviductal glycoprotein 1, 120kDa
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIDD1 p53-induced death domain protein 1
PLAU plasminogen activator, urokinase
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PVT1 Pvt1 oncogene (non-protein coding)
RAB32 RAB32, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS20 regulator of G-protein signaling 20
RNF19B ring finger protein 19B
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIRT5 sirtuin 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
STOM stomatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TES testin LIM domain protein
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XPC xeroderma pigmentosum, complementation group C
ZNF384 zinc finger protein 384
ZNF549 zinc finger protein 549

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
AHDC1 AT hook, DNA binding motif, containing 1
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP11A Rho GTPase activating protein 11A
ARMC6 armadillo repeat containing 6
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD5 ATPase family, AAA domain containing 5
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLM Bloom syndrome, RecQ helicase-like
BMP4 bone morphogenetic protein 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C19ORF40 chromosome 19 open reading frame 40
C2ORF44 chromosome 2 open reading frame 44
CBX8 chromobox homolog 8
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNF cyclin F
CCNO cyclin O
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPE centromere protein E, 312kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F8 E2F transcription factor 8
EFHD2 EF-hand domain family, member D2
ENO2 enolase 2 (gamma, neuronal)
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAAH fatty acid amide hydrolase
FAM64A family with sequence similarity 64, member A
FBXL6 F-box and leucine-rich repeat protein 6
FBXO5 F-box protein 5
FHOD1 formin homology 2 domain containing 1
FLT4 fms-related tyrosine kinase 4
GHR growth hormone receptor
GPR19 G protein-coupled receptor 19
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4D histone cluster 1, H4d
HPN hepsin
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
IRX5 iroquois homeobox 5
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LHX6 LIM homeobox 6
LOC730101 uncharacterized LOC730101
LRRC20 leucine rich repeat containing 20
LRRC61 leucine rich repeat containing 61
MCM10 minichromosome maintenance complex component 10
MDM1 Mdm1 nuclear protein homolog (mouse)
MRPS18C mitochondrial ribosomal protein S18C
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
NDC80 NDC80 kinetochore complex component
NEK11 NIMA-related kinase 11
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
ORC1 origin recognition complex, subunit 1
PAQR4 progestin and adipoQ receptor family member IV
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLK1 polo-like kinase 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPT2 palmitoyl-protein thioesterase 2
PRR15L proline rich 15-like
PSRC1 proline/serine-rich coiled-coil 1
PVRL3 poliovirus receptor-related 3
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SKI SKI proto-oncogene
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TMEM180 transmembrane protein 180
TRAF2 TNF receptor-associated factor 2
TRAF5 TNF receptor-associated factor 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TROAP trophinin associated protein
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASH2 vasohibin 2
ZDHHC11 zinc finger, DHHC-type containing 11