pyruvate dehydrogenase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). (Gene Ontology, GO_0045254)
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154 proteins co-occuring with the pyruvate dehydrogenase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DLD dihydrolipoamide dehydrogenase 2.95417
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.66208
PDHX pyruvate dehydrogenase complex, component X 2.50906
DLAT dihydrolipoamide S-acetyltransferase 2.12021
PDHB pyruvate dehydrogenase (lipoamide) beta 2.03869
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.91951
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 1.79574
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 1.76238
PC pyruvate carboxylase 1.68543
TKT transketolase 1.59546
ACSS2 acyl-CoA synthetase short-chain family member 2 1.3752
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.33739
INS insulin 1.21376
CS citrate synthase 1.19006
PDK2 pyruvate dehydrogenase kinase, isozyme 2 1.16953
LIPT1 lipoyltransferase 1 1.15364
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.09645
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.07106
BCKDK branched chain ketoacid dehydrogenase kinase 1.06448
PFKM phosphofructokinase, muscle 0.93785
PKLR pyruvate kinase, liver and RBC 0.924666
PKM pyruvate kinase, muscle 0.881477
TFEC transcription factor EC 0.86169
MDH1 malate dehydrogenase 1, NAD (soluble) 0.846991
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.846532
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.815322
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G 0.802479
ACSF2 acyl-CoA synthetase family member 2 0.776841
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.774558
LDHA lactate dehydrogenase A 0.749094
PPARA peroxisome proliferator-activated receptor alpha 0.735115
ACO2 aconitase 2, mitochondrial 0.725258
GLDC glycine dehydrogenase (decarboxylating) 0.712795
THTPA thiamine triphosphatase 0.705714
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 0.672026
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.627335
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.624781
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 0.606973
CPT1A carnitine palmitoyltransferase 1A (liver) 0.604017
CRAT carnitine O-acetyltransferase 0.579251
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.578416
CD79A CD79a molecule, immunoglobulin-associated alpha 0.576329
MGAM maltase-glucoamylase 0.575495
CRYZ crystallin, zeta (quinone reductase) 0.563847
ASPRV1 aspartic peptidase, retroviral-like 1 0.558042
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.553078
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.523067
FOXO1 forkhead box O1 0.49742
PPARG peroxisome proliferator-activated receptor gamma 0.496205
NPTX2 neuronal pentraxin II 0.491348
HK1 hexokinase 1 0.488115
HADH hydroxyacyl-CoA dehydrogenase 0.487711
ACSS3 acyl-CoA synthetase short-chain family member 3 0.482467
DBT dihydrolipoamide branched chain transacylase E2 0.478843
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 0.476429
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.462398
HK2 hexokinase 2 0.454019
BOLA3 bolA family member 3 0.445275
ANKK1 ankyrin repeat and kinase domain containing 1 0.440124
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.438937
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.432224
ACAA2 acetyl-CoA acyltransferase 2 0.429072
ZDHHC23 zinc finger, DHHC-type containing 23 0.420428
ACLY ATP citrate lyase 0.419252
PYGB phosphorylase, glycogen; brain 0.419252
PYGL phosphorylase, glycogen, liver 0.41886
PYGM phosphorylase, glycogen, muscle 0.416902
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.414555
ESRRA estrogen-related receptor alpha 0.412992
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.409869
SOX13 SRY (sex determining region Y)-box 13 0.406361
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.391615
SP100 SP100 nuclear antigen 0.387365
PFKL phosphofructokinase, liver 0.367006
CCBL1 cysteine conjugate-beta lyase, cytoplasmic 0.366241
WFDC2 WAP four-disulfide core domain 2 0.362422
ACSS1 acyl-CoA synthetase short-chain family member 1 0.357847
PIGR polymeric immunoglobulin receptor 0.355183
CD4 CD4 molecule 0.345314
GCG glucagon 0.343042
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.338506
DAND5 DAN domain family member 5, BMP antagonist 0.338128
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.331719
LDHAL6A lactate dehydrogenase A-like 6A 0.331342
LIAS lipoic acid synthetase 0.326078
ASPN asporin 0.32195
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.320826
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.316334
TGM2 transglutaminase 2 0.312224
ILVBL ilvB (bacterial acetolactate synthase)-like 0.30924
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.307004
ETFB electron-transfer-flavoprotein, beta polypeptide 0.305515
G6PD glucose-6-phosphate dehydrogenase 0.293637
AKAP4 A kinase (PRKA) anchor protein 4 0.293637
TPI1 triosephosphate isomerase 1 0.293267
PANK1 pantothenate kinase 1 0.278877
GPR17 G protein-coupled receptor 17 0.277038
CUTA cutA divalent cation tolerance homolog (E. coli) 0.2708
CDKL5 cyclin-dependent kinase-like 5 0.266774
NFU1 NFU1 iron-sulfur cluster scaffold 0.266774
THRB thyroid hormone receptor, beta 0.262025
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.261296
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.254017
LRG1 leucine-rich alpha-2-glycoprotein 1 0.251839
SPAG11A sperm associated antigen 11A 0.251839
GCK glucokinase (hexokinase 4) 0.243879
MICA MHC class I polypeptide-related sequence A 0.242437
GLRX5 glutaredoxin 5 0.236324
SPAG11B sperm associated antigen 11B 0.227752
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 0.227397
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.212627
LDHB lactate dehydrogenase B 0.210203
ALB albumin 0.207794
KLK15 kallikrein-related peptidase 15 0.20574
DDN dendrin 0.198325
CHKB choline kinase beta 0.196669
PIR pirin (iron-binding nuclear protein) 0.195681
ALPPL2 alkaline phosphatase, placental-like 2 0.192423
ALPL alkaline phosphatase, liver/bone/kidney 0.191777
ALPP alkaline phosphatase, placental 0.191456
G6PC glucose-6-phosphatase, catalytic subunit 0.188274
MMD monocyte to macrophage differentiation-associated 0.187646
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.184547
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.184547
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.183631
SRSF5 serine/arginine-rich splicing factor 5 0.180634
ZNF79 zinc finger protein 79 0.179752
PGLS 6-phosphogluconolactonase 0.178299
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.17687
GSR glutathione reductase 0.173003
LST1 leukocyte specific transcript 1 0.169604
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.167856
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.16477
LDHAL6B lactate dehydrogenase A-like 6B 0.16477
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.1632
FASN fatty acid synthase 0.161693
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.159462
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.159268
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.158129
ASL argininosuccinate lyase 0.157578
PDC phosducin 0.14196
CYR61 cysteine-rich, angiogenic inducer, 61 0.141356
RIPK4 receptor-interacting serine-threonine kinase 4 0.140955
GADD45A growth arrest and DNA-damage-inducible, alpha 0.140087
CD1D CD1d molecule 0.139315
CD99 CD99 molecule 0.138973
SIRT3 sirtuin 3 0.138299
TYRO3 TYRO3 protein tyrosine kinase 0.138032
VCP valosin containing protein 0.13756
P4HB prolyl 4-hydroxylase, beta polypeptide 0.133604
IRS1 insulin receptor substrate 1 0.132189
STAT1 signal transducer and activator of transcription 1, 91kDa 0.129103
GUSB glucuronidase, beta 0.129021
CALR calreticulin 0.128235