psoriasis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. (Experimental Factor Ontology, EFO_0000676)
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Genes

350 genes co-occuring with the biological term psoriasis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR2 atypical chemokine receptor 2
ADAM17 ADAM metallopeptidase domain 17
ADAM33 ADAM metallopeptidase domain 33
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA6 annexin A6
APOE apolipoprotein E
AREG amphiregulin
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AURKA aurora kinase A
AURKB aurora kinase B
B3GAT1 beta-1,3-glucuronyltransferase 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BSG basigin (Ok blood group)
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C6ORF15 chromosome 6 open reading frame 15
CA2 carbonic anhydrase II
CADM2 cell adhesion molecule 2
CAMP cathelicidin antimicrobial peptide
CARD14 caspase recruitment domain family, member 14
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL27 chemokine (C-C motif) ligand 27
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CCL4L1 chemokine (C-C motif) ligand 4-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD1D CD1d molecule
CD209 CD209 molecule
CD226 CD226 molecule
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD99 CD99 molecule
CDH13 cadherin 13
CDK6 cyclin-dependent kinase 6
CDSN corneodesmosin
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLDN1 claudin 1
CLDN4 claudin 4
CLDN7 claudin 7
CMKLR1 chemerin chemokine-like receptor 1
COMT catechol-O-methyltransferase
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CSTA cystatin A (stefin A)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR6 chemokine (C-X-C motif) receptor 6
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DCSTAMP dendrocyte expressed seven transmembrane protein
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB4A defensin, beta 4A
DPP4 dipeptidyl-peptidase 4
DST dystonin
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLG filaggrin
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
GCG glucagon
GJB2 gap junction protein, beta 2, 26kDa
GLP1R glucagon-like peptide 1 receptor
GPX1 glutathione peroxidase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSTM1 glutathione S-transferase mu 1
HAVCR2 hepatitis A virus cellular receptor 2
HAX1 HCLS1 associated protein X-1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HP haptoglobin
HPSE heparanase
HRH4 histamine receptor H4
HSPB1 heat shock 27kDa protein 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL21 interleukin 21
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27 interleukin 27
IL33 interleukin 33
IL36A interleukin 36, alpha
IL36G interleukin 36, gamma
IL36RN interleukin 36 receptor antagonist
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
ITGA1 integrin, alpha 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITLN1 intelectin 1 (galactofuranose binding)
JUN jun proto-oncogene
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
LCE3B late cornified envelope 3B
LCE3C late cornified envelope 3C
LCE3D late cornified envelope 3D
LCN2 lipocalin 2
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LNPEP leucyl/cystinyl aminopeptidase
LPA lipoprotein, Lp(a)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LYNX1 Ly6/neurotoxin 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MGST2 microsomal glutathione S-transferase 2
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR125B1 microRNA 125b-1
MIR143 microRNA 143
MIR19A microRNA 19a
MIR203A microRNA 203a
MIR21 microRNA 21
MIR210 microRNA 210
MIR221 microRNA 221
MIR222 microRNA 222
MIR223 microRNA 223
MIR31 microRNA 31
MIR4516 microRNA 4516
MIR492 microRNA 492
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MSN moesin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOA5 nuclear receptor coactivator 5
NCR2 natural cytotoxicity triggering receptor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH4 notch 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OCLN occludin
PEPD peptidase D
PF4 platelet factor 4
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPBPP1 pro-platelet basic protein pseudogene 1
PRDX2 peroxiredoxin 2
PRKCZ protein kinase C, zeta
PRL prolactin
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSORS1C1 psoriasis susceptibility 1 candidate 1
PSORS1C2 psoriasis susceptibility 1 candidate 2
PSORS4 psoriasis susceptibility 4
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX3 pentraxin 3, long
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
REG3A regenerating islet-derived 3 alpha
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RNF114 ring finger protein 114
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPTOR regulatory associated protein of MTOR, complex 1
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
SDC1 syndecan 1
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5
SELPLG selectin P ligand
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHBG sex hormone-binding globulin
SLC12A8 solute carrier family 12, member 8
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2A small proline-rich protein 2A
SPRR2B small proline-rich protein 2B
SPRR2D small proline-rich protein 2D
SPRR2E small proline-rich protein 2E
SPRR2F small proline-rich protein 2F
SPRR2G small proline-rich protein 2G
SPRR3 small proline-rich protein 3
SPRR4 small proline-rich protein 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STIP1 stress-induced phosphoprotein 1
SUMO4 small ubiquitin-like modifier 4
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGM5 transglutaminase 5
TIMP3 TIMP metallopeptidase inhibitor 3
TJP1 tight junction protein 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMPRSS11D transmembrane protease, serine 11D
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TP63 tumor protein p63
TRAF3IP2 TRAF3 interacting protein 2
TRD T cell receptor delta locus
TRG T cell receptor gamma locus
TRIM32 tripartite motif containing 32
TSPO translocator protein (18kDa)
UBE2N ubiquitin-conjugating enzyme E2N
USP15 ubiquitin specific peptidase 15
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WIF1 WNT inhibitory factor 1
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
ZNF148 zinc finger protein 148
ZNF750 zinc finger protein 750