psoriasis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales). (Human Phenotype Ontology, HP_0003765)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0003765
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Genes

142 genes associated with the psoriasis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-C major histocompatibility complex, class I, C 2.81405
C2 complement component 2 2.30667
MUC22 mucin 22 2.30364
TNXB tenascin XB 2.25159
HCP5 HLA complex P5 (non-protein coding) 2.13087
IL12B interleukin 12B 2.12703
NOTCH4 notch 4 2.08718
ABHD16A abhydrolase domain containing 16A 2.0769
CCHCR1 coiled-coil alpha-helical rod protein 1 2.01825
TNF tumor necrosis factor 2.00775
TRAF3IP2 TRAF3 interacting protein 2 1.99238
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 1.94848
LST1 leukocyte specific transcript 1 1.91652
HLA-DOB major histocompatibility complex, class II, DO beta 1.90677
LOC285626 uncharacterized LOC285626 1.86558
MUC21 mucin 21, cell surface associated 1.85908
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.85576
TRIM15 tripartite motif containing 15 1.84896
IL13 interleukin 13 1.71244
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.70308
TRIM40 tripartite motif containing 40 1.69048
C6ORF10 chromosome 6 open reading frame 10 1.66957
DDR1 discoidin domain receptor tyrosine kinase 1 1.63532
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 1.63258
TCF19 transcription factor 19 1.59583
DPCR1 diffuse panbronchiolitis critical region 1 1.56963
MCCD1 mitochondrial coiled-coil domain 1 1.55422
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.5239
HCG22 HLA complex group 22 1.4874
GJB2 gap junction protein, beta 2, 26kDa 1.48078
CAST calpastatin 1.47083
TYK2 tyrosine kinase 2 1.46277
NOS2 nitric oxide synthase 2, inducible 1.46277
ZNF816-ZNF321P ZNF816-ZNF321P readthrough 1.42236
FBXL19 F-box and leucine-rich repeat protein 19 1.35901
STAT2 signal transducer and activator of transcription 2, 113kDa 1.35521
CSMD1 CUB and Sushi multiple domains 1 1.28765
SPATA2 spermatogenesis associated 2 1.24751
KIAA0391 KIAA0391 1.21853
IL23R interleukin 23 receptor 1.19958
RNF114 ring finger protein 114 1.00059
COG6 component of oligomeric golgi complex 6 1.00059
OAF OAF homolog (Drosophila) 0.977911
ANO2 anoctamin 2, calcium activated chloride channel 0.956975
TFDP1 transcription factor Dp-1 0.956697
THTPA thiamine triphosphatase 0.953171
TSC1 tuberous sclerosis 1 0.899912
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.881079
BCL7C B-cell CLL/lymphoma 7C 0.87241
IMPG2 interphotoreceptor matrix proteoglycan 2 0.852507
LOC400655 uncharacterized LOC400655 0.846368
ANKRD55 ankyrin repeat domain 55 0.835282
LRRN2 leucine rich repeat neuronal 2 0.821408
ARHGAP31 Rho GTPase activating protein 31 0.81905
ACO1 aconitase 1, soluble 0.813733
SETD1A SET domain containing 1A 0.809986
FTO fat mass and obesity associated 0.802966
RYR2 ryanodine receptor 2 (cardiac) 0.800972
MYLK myosin light chain kinase 0.792855
EFCAB5 EF-hand calcium binding domain 5 0.792855
TSPAN18 tetraspanin 18 0.789144
C10ORF128 chromosome 10 open reading frame 128 0.788506
SOX5 SRY (sex determining region Y)-box 5 0.786
ILF3 interleukin enhancer binding factor 3, 90kDa 0.784165
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.780031
KIAA0922 KIAA0922 0.778318
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.777754
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 0.77499
MAML2 mastermind-like 2 (Drosophila) 0.761926
CD244 CD244 molecule, natural killer cell receptor 2B4 0.747666
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.744976
INSC inscuteable homolog (Drosophila) 0.741936
LOC440040 glutamate receptor, metabotropic 5 pseudogene 0.729372
STXBP6 syntaxin binding protein 6 (amisyn) 0.728537
C15ORF26 chromosome 15 open reading frame 26 0.726078
ESPNP espin pseudogene 0.726078
FAM91A1 family with sequence similarity 91, member A1 0.725273
TGM6 transglutaminase 6 0.721729
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.720577
EXOC2 exocyst complex component 2 0.717572
YPEL1 yippee-like 1 (Drosophila) 0.712886
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.710116
ELMO1 engulfment and cell motility 1 0.708265
MBNL2 muscleblind-like splicing regulator 2 0.702479
MAPK6 mitogen-activated protein kinase 6 0.701084
ANKRD44 ankyrin repeat domain 44 0.699027
CNTNAP5 contactin associated protein-like 5 0.694714
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.691522
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.683684
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.67542
CTNND2 catenin (cadherin-associated protein), delta 2 0.672779
DZANK1 double zinc ribbon and ankyrin repeat domains 1 0.669923
CDH13 cadherin 13 0.669923
SCG3 secretogranin III 0.668803
IQSEC2 IQ motif and Sec7 domain 2 0.658738
IL1R2 interleukin 1 receptor, type II 0.656743
TSEN54 TSEN54 tRNA splicing endonuclease subunit 0.654787
COL4A2 collagen, type IV, alpha 2 0.654545
ASL argininosuccinate lyase 0.650987
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.650754
LOC152225 uncharacterized LOC152225 0.643909
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.640092
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.640092
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.631549
ZNF365 zinc finger protein 365 0.631333
FAM35A family with sequence similarity 35, member A 0.629625
MOB3B MOB kinase activator 3B 0.627321
CDH19 cadherin 19, type 2 0.62227
CRLS1 cardiolipin synthase 1 0.617271
COL6A2 collagen, type VI, alpha 2 0.615351
LRP1B low density lipoprotein receptor-related protein 1B 0.614969
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.612151
ETV7 ets variant 7 0.610497
ZNF605 zinc finger protein 605 0.610497
GAK cyclin G associated kinase 0.602774
DPF3 D4, zinc and double PHD fingers, family 3 0.600435
LINC01194 long intergenic non-protein coding RNA 1194 0.596707
AKAP13 A kinase (PRKA) anchor protein 13 0.596548
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.593113
FA2H fatty acid 2-hydroxylase 0.592349
CEP72 centrosomal protein 72kDa 0.59024
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.58687
TCF4 transcription factor 4 0.585136
TTLL5 tubulin tyrosine ligase-like family member 5 0.579744
ZC3H12C zinc finger CCCH-type containing 12C 0.579512
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.579049
TMEM51-AS1 TMEM51 antisense RNA 1 0.576102
FUT2 fucosyltransferase 2 (secretor status included) 0.575658
C9ORF171 chromosome 9 open reading frame 171 0.575216
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.574447
PEMT phosphatidylethanolamine N-methyltransferase 0.57412
ERBB4 erb-b2 receptor tyrosine kinase 4 0.573902
SOS2 son of sevenless homolog 2 (Drosophila) 0.573145
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.531207
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.528162
CSN3 casein kappa 0.521853
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.498792
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.466034
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.458433
ERAP2 endoplasmic reticulum aminopeptidase 2 0.436956
BCL2 B-cell CLL/lymphoma 2 0.43652
ADAMTSL1 ADAMTS-like 1 0.425981