psoriasis Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales). (Human Phenotype Ontology, HP_0003765)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:8893
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Genes

151 genes associated with the disease psoriasis in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
C2 complement component 2 2.32917
MUC22 mucin 22 2.32485
TNXB tenascin XB 2.30208
HLA-C major histocompatibility complex, class I, C 2.26651
HCP5 HLA complex P5 (non-protein coding) 2.18136
IL12B interleukin 12B 2.17705
NOTCH4 notch 4 2.12391
ABHD16A abhydrolase domain containing 16A 2.11485
CCHCR1 coiled-coil alpha-helical rod protein 1 2.05528
TNF tumor necrosis factor 2.04254
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.00264
LST1 leukocyte specific transcript 1 1.97152
HLA-DOB major histocompatibility complex, class II, DO beta 1.96593
LOC285626 uncharacterized LOC285626 1.92668
MUC21 mucin 21, cell surface associated 1.91997
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.91712
TRIM15 tripartite motif containing 15 1.91137
TRAF3IP2 TRAF3 interacting protein 2 1.8787
IL13 interleukin 13 1.80297
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.79836
TRIM40 tripartite motif containing 40 1.79149
C6ORF10 chromosome 6 open reading frame 10 1.77339
ZMIZ1 zinc finger, MIZ-type containing 1 1.74809
DDR1 discoidin domain receptor tyrosine kinase 1 1.7424
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 1.74
TCF19 transcription factor 19 1.71445
DPCR1 diffuse panbronchiolitis critical region 1 1.69863
MCCD1 mitochondrial coiled-coil domain 1 1.68731
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.65151
HCG22 HLA complex group 22 1.62287
GJB2 gap junction protein, beta 2, 26kDa 1.61744
CAST calpastatin 1.60875
NOS2 nitric oxide synthase 2, inducible 1.60174
TYK2 tyrosine kinase 2 1.60174
ZNF816-ZNF321P ZNF816-ZNF321P readthrough 1.56047
FBXL19 F-box and leucine-rich repeat protein 19 1.51254
STAT2 signal transducer and activator of transcription 2, 113kDa 1.50906
CSMD1 CUB and Sushi multiple domains 1 1.45826
SPATA2 spermatogenesis associated 2 1.42467
KIAA0391 KIAA0391 1.39396
IL23R interleukin 23 receptor 1.37327
ZNF365 zinc finger protein 365 1.36661
NOTCH1 notch 1 1.274
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 1.17002
COG6 component of oligomeric golgi complex 6 1.14463
RNF114 ring finger protein 114 1.14463
OAF OAF homolog (Drosophila) 1.11813
ANO2 anoctamin 2, calcium activated chloride channel 1.09343
TFDP1 transcription factor Dp-1 1.09313
THTPA thiamine triphosphatase 1.08934
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.0793
LDLRAD3 low density lipoprotein receptor class A domain containing 3 1.0725
TSC1 tuberous sclerosis 1 1.02476
ZDHHC23 zinc finger, DHHC-type containing 23 1.00407
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 1.00185
BCL7C B-cell CLL/lymphoma 7C 0.991428
CAPZB capping protein (actin filament) muscle Z-line, beta 0.986376
IMPG2 interphotoreceptor matrix proteoglycan 2 0.967726
LOC400655 uncharacterized LOC400655 0.960778
ANKRD55 ankyrin repeat domain 55 0.948266
LRRN2 leucine rich repeat neuronal 2 0.932777
ARHGAP31 Rho GTPase activating protein 31 0.930169
ACO1 aconitase 1, soluble 0.92437
SETD1A SET domain containing 1A 0.920453
RALGDS ral guanine nucleotide dissociation stimulator 0.918185
FTO fat mass and obesity associated 0.912987
RYR2 ryanodine receptor 2 (cardiac) 0.910724
MYLK myosin light chain kinase 0.901524
EFCAB5 EF-hand calcium binding domain 5 0.901524
TSPAN18 tetraspanin 18 0.897579
C10ORF128 chromosome 10 open reading frame 128 0.896938
SOX5 SRY (sex determining region Y)-box 5 0.894421
ILF3 interleukin enhancer binding factor 3, 90kDa 0.892579
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.888428
KIAA0922 KIAA0922 0.886521
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.885884
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 0.882764
MAML2 mastermind-like 2 (Drosophila) 0.868556
IL1R2 interleukin 1 receptor, type II 0.865959
CD244 CD244 molecule, natural killer cell receptor 2B4 0.853791
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.850837
INSC inscuteable homolog (Drosophila) 0.847502
LOC440040 glutamate receptor, metabotropic 5 pseudogene 0.834806
STXBP6 syntaxin binding protein 6 (amisyn) 0.83399
ESPNP espin pseudogene 0.831584
C15ORF26 chromosome 15 open reading frame 26 0.831584
FAM91A1 family with sequence similarity 91, member A1 0.830742
TGM6 transglutaminase 6 0.826866
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.825607
EXOC2 exocyst complex component 2 0.822323
YPEL1 yippee-like 1 (Drosophila) 0.817207
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.814185
ELMO1 engulfment and cell motility 1 0.812342
MBNL2 muscleblind-like splicing regulator 2 0.806666
MAPK6 mitogen-activated protein kinase 6 0.805298
ANKRD44 ankyrin repeat domain 44 0.80328
CNTNAP5 contactin associated protein-like 5 0.798811
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.795282
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.786631
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.778061
CTNND2 catenin (cadherin-associated protein), delta 2 0.775452
CDH13 cadherin 13 0.772631
DZANK1 double zinc ribbon and ankyrin repeat domains 1 0.772631
SCG3 secretogranin III 0.771525
IQSEC2 IQ motif and Sec7 domain 2 0.760692
TSEN54 TSEN54 tRNA splicing endonuclease subunit 0.756331
COL4A2 collagen, type IV, alpha 2 0.756064
ASL argininosuccinate lyase 0.752142
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.751885
LOC152225 uncharacterized LOC152225 0.744948
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.741181
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.741181
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.732392
FAM35A family with sequence similarity 35, member A 0.730285
MOB3B MOB kinase activator 3B 0.727764
CDH19 cadherin 19, type 2 0.722241
CRLS1 cardiolipin synthase 1 0.716781
COL6A2 collagen, type VI, alpha 2 0.714752
LRP1B low density lipoprotein receptor-related protein 1B 0.714351
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.71139
ETV7 ets variant 7 0.709651
ZNF605 zinc finger protein 605 0.709651
GAK cyclin G associated kinase 0.701544
DPF3 D4, zinc and double PHD fingers, family 3 0.699101
LINC01194 long intergenic non-protein coding RNA 1194 0.695208
AKAP13 A kinase (PRKA) anchor protein 13 0.695042
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.691457
FA2H fatty acid 2-hydroxylase 0.69066
CEP72 centrosomal protein 72kDa 0.688459
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.684944
TCF4 transcription factor 4 0.683009
TTLL5 tubulin tyrosine ligase-like family member 5 0.676587
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.676587
ZC3H12C zinc finger CCCH-type containing 12C 0.67631
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.67576
TMEM51-AS1 TMEM51 antisense RNA 1 0.672258
FUT2 fucosyltransferase 2 (secretor status included) 0.67173
C9ORF171 chromosome 9 open reading frame 171 0.671205
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.670361
PEMT phosphatidylethanolamine N-methyltransferase 0.670054
ERBB4 erb-b2 receptor tyrosine kinase 4 0.669849
SOS2 son of sevenless homolog 2 (Drosophila) 0.669138
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.625315
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.621951
CSN3 casein kappa 0.614766
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.586345
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.54661
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.537527
ERAP2 endoplasmic reticulum aminopeptidase 2 0.5118
BCL2 B-cell CLL/lymphoma 2 0.511215
ADAMTSL1 ADAMTS-like 1 0.499161