protease Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

446 genes co-occuring with the biological term protease in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE2 angiotensin I converting enzyme 2
ACO2 aconitase 2, mitochondrial
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
ADAM17 ADAM metallopeptidase domain 17
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADAM9 ADAM metallopeptidase domain 9
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AFG3L2 AFG3-like AAA ATPase 2
AGER advanced glycosylation end product-specific receptor
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AIP aryl hydrocarbon receptor interacting protein
APAF1 apoptotic peptidase activating factor 1
APIP APAF1 interacting protein
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASPRV1 aspartic peptidase, retroviral-like 1
ATF1 activating transcription factor 1
ATF6 activating transcription factor 6
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
AXIN1 axin 1
AXIN2 axin 2
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BAK1 BCL2-antagonist/killer 1
BID BH3 interacting domain death agonist
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP1 bone morphogenetic protein 1
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C5 complement component 5
C5AR1 complement component 5a receptor 1
CAMP cathelicidin antimicrobial peptide
CAPN1 calpain 1, (mu/I) large subunit
CAPN10 calpain 10
CAPN2 calpain 2, (m/II) large subunit
CAPN9 calpain 9
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFH complement factor H
CFHR1 complement factor H-related 1
CFI complement factor I
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CMA1 chymase 1, mast cell
CMKLR1 chemerin chemokine-like receptor 1
CORIN corin, serine peptidase
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPA4 carboxypeptidase A4
CRBN cereblon
CREB3 cAMP responsive element binding protein 3
CRYBA1 crystallin, beta A1
CSN2 casein beta
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CST1 cystatin SN
CST3 cystatin C
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTGF connective tissue growth factor
CTRL chymotrypsin-like
CTSB cathepsin B
CTSD cathepsin D
CTSG cathepsin G
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CTSV cathepsin V
CTTN cortactin
CUL1 cullin 1
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCD dermcidin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND6A DENN/MADD domain containing 6A
DGKD diacylglycerol kinase, delta 130kDa
DLD dihydrolipoamide dehydrogenase
DMBT1 deleted in malignant brain tumors 1
DPP4 dipeptidyl-peptidase 4
DPP9 dipeptidyl-peptidase 9
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELANE elastase, neutrophil expressed
ELK1 ELK1, member of ETS oncogene family
ELN elastin
EP300 E1A binding protein p300
EPPIN epididymal peptidase inhibitor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
F10 coagulation factor X
F11 coagulation factor XI
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FAP fibroblast activation protein, alpha
FBN1 fibrillin 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF23 fibroblast growth factor 23
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FURIN furin (paired basic amino acid cleaving enzyme)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALE UDP-galactose-4-epimerase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPX8 glutathione peroxidase 8 (putative)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMM granzyme M (lymphocyte met-ase 1)
HABP2 hyaluronan binding protein 2
HAMP hepcidin antimicrobial peptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HM13 histocompatibility (minor) 13
HMGB2 high mobility group box 2
HP haptoglobin
HPN hepsin
HPSE heparanase
HPSE2 heparanase 2 (inactive)
HPX hemopexin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTRA3 HtrA serine peptidase 3
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IFIH1 interferon induced with helicase C domain 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL13 interleukin 13
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
ISG15 ISG15 ubiquitin-like modifier
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF1B kinesin family member 1B
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KMT2A lysine (K)-specific methyltransferase 2A
LAMA1 laminin, alpha 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEPR leptin receptor
LIPG lipase, endothelial
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTF lactotransferrin
LY96 lymphocyte antigen 96
MALT1 MALT1 paracaspase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MAVS mitochondrial antiviral signaling protein
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN1 mucolipin 1
MESDC2 mesoderm development candidate 2
MFGE8 milk fat globule-EGF factor 8 protein
MIR145 microRNA 145
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP21 matrix metallopeptidase 21
MMP25 matrix metallopeptidase 25
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTDH metadherin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC7 mucin 7, secreted
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFS1 NFS1 cysteine desulfurase
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOX1 NADPH oxidase 1
NPSA novel prostate-specific antigen
NRF1 nuclear respiratory factor 1
NUCB1 nucleobindin 1
NUP98 nucleoporin 98kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PCDHGC3 protocadherin gamma subfamily C, 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK9 proprotein convertase subtilisin/kexin type 9
PDGFD platelet derived growth factor D
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PEX5 peroxisomal biogenesis factor 5
PGAM5 phosphoglycerate mutase family member 5
PGC progastricsin (pepsinogen C)
PI3 peptidase inhibitor 3, skin-derived
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PINK1 PTEN induced putative kinase 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PML promyelocytic leukemia
POR P450 (cytochrome) oxidoreductase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS1 protease, serine, 1 (trypsin 1)
PRSS16 protease, serine, 16 (thymus)
PRSS22 protease, serine, 22
PRSS3 protease, serine, 3
PRSS36 protease, serine, 36
PRSS50 protease, serine, 50
PRSS56 protease, serine, 56
PRSS8 protease, serine, 8
PRTN3 proteinase 3
PSAP prosaposin
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
PYCARD PYD and CARD domain containing
RAB14 RAB14, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RHBDD1 rhomboid domain containing 1
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
S100P S100 calcium binding protein P
SCARA3 scavenger receptor class A, member 3
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC1 syndecan 1
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SENP1 SUMO1/sentrin specific peptidase 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SENP6 SUMO1/sentrin specific peptidase 6
SENP7 SUMO1/sentrin specific peptidase 7
SENP8 SUMO/sentrin specific peptidase family member 8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SET SET nuclear proto-oncogene
SFTPC surfactant protein C
SFTPD surfactant protein D
SKP1 S-phase kinase-associated protein 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLPI secretory leukocyte peptidase inhibitor
SMAD2 SMAD family member 2
SMN1 survival of motor neuron 1, telomeric
SNAP25 synaptosomal-associated protein, 25kDa
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPINK6 serine peptidase inhibitor, Kazal type 6
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPINT3 serine peptidase inhibitor, Kunitz type, 3
SPPL3 signal peptide peptidase like 3
SRA1 steroid receptor RNA activator 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAMBP STAM binding protein
STAR steroidogenic acute regulatory protein
STEAP3 STEAP family member 3, metalloreductase
STK38 serine/threonine kinase 38
STK38L serine/threonine kinase 38 like
STOM stomatin
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TAGLN transgelin
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TMPRSS11B transmembrane protease, serine 11B
TMPRSS11D transmembrane protease, serine 11D
TMPRSS13 transmembrane protease, serine 13
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TMPRSS5 transmembrane protease, serine 5
TMPRSS6 transmembrane protease, serine 6
TMPRSS9 transmembrane protease, serine 9
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TP73 tumor protein p73
TPP1 tripeptidyl peptidase I
TPP2 tripeptidyl peptidase II
TPSG1 tryptase gamma 1
TRABD2A TraB domain containing 2A
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRIM25 tripartite motif containing 25
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSPYL2 TSPY-like 2
TTR transthyretin
TYSND1 trypsin domain containing 1
UFM1 ubiquitin-fold modifier 1
ULBP1 UL16 binding protein 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP12 ubiquitin specific peptidase 12
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP15 ubiquitin specific peptidase 15
USP16 ubiquitin specific peptidase 16
USP18 ubiquitin specific peptidase 18
USP2 ubiquitin specific peptidase 2
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
USP34 ubiquitin specific peptidase 34
USP37 ubiquitin specific peptidase 37
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
VASP vasodilator-stimulated phosphoprotein
VEGFC vascular endothelial growth factor C
VIM vimentin
VWF von Willebrand factor
WFDC12 WAP four-disulfide core domain 12
WFDC2 WAP four-disulfide core domain 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZMPSTE24 zinc metallopeptidase STE24