proscillaridin-7340 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the proscillaridin-7340 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AFF4 AF4/FMR2 family, member 4
AKAP8L A kinase (PRKA) anchor protein 8-like
AMOTL2 angiomotin like 2
ATF3 activating transcription factor 3
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
BLZF1 basic leucine zipper nuclear factor 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC186 coiled-coil domain containing 186
CCNL1 cyclin L1
CLDN1 claudin 1
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EDRF1 erythroid differentiation regulatory factor 1
EEA1 early endosome antigen 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
EPHA2 EPH receptor A2
FAM46A family with sequence similarity 46, member A
FASTKD2 FAST kinase domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HCFC2 host cell factor C2
HIC2 hypermethylated in cancer 2
HIST2H2BE histone cluster 2, H2be
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC13 homeobox C13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL6 interleukin 6
IP6K2 inositol hexakisphosphate kinase 2
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR4A2 nuclear receptor subfamily 4, group A, member 2
OVOL1 ovo-like zinc finger 1
PCDH9 protocadherin 9
PNRC1 proline-rich nuclear receptor coactivator 1
POU2F1 POU class 2 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM5 RNA binding motif protein 5
SERTAD3 SERTA domain containing 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SIK1 salt-inducible kinase 1
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
STK17B serine/threonine kinase 17b
STX3 syntaxin 3
TCF25 transcription factor 25 (basic helix-loop-helix)
TGFB2 transforming growth factor, beta 2
TRA2A transformer 2 alpha homolog (Drosophila)
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
YTHDC1 YTH domain containing 1
ZBTB40 zinc finger and BTB domain containing 40
ZBTB43 zinc finger and BTB domain containing 43
ZFAND6 zinc finger, AN1-type domain 6
ZFX zinc finger protein, X-linked
ZMYM2 zinc finger, MYM-type 2
ZNF654 zinc finger protein 654
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADORA2B adenosine A2b receptor
AGGF1 angiogenic factor with G patch and FHA domains 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKRD46 ankyrin repeat domain 46
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMCX1 armadillo repeat containing, X-linked 1
ASB13 ankyrin repeat and SOCS box containing 13
BBX bobby sox homolog (Drosophila)
CBX7 chromobox homolog 7
CCDC15 coiled-coil domain containing 15
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CXORF40A chromosome X open reading frame 40A
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAAF2 dynein, axonemal, assembly factor 2
EAF2 ELL associated factor 2
EGR3 early growth response 3
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ETAA1 Ewing tumor-associated antigen 1
FADD Fas (TNFRSF6)-associated via death domain
FAM86B1 family with sequence similarity 86, member B1
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FHOD1 formin homology 2 domain containing 1
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GPR19 G protein-coupled receptor 19
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HIRIP3 HIRA interacting protein 3
HPS6 Hermansky-Pudlak syndrome 6
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IFRD1 interferon-related developmental regulator 1
IL4R interleukin 4 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KIAA0125 KIAA0125
KRCC1 lysine-rich coiled-coil 1
LOC100287590 uncharacterized LOC100287590
LRRC61 leucine rich repeat containing 61
MINA MYC induced nuclear antigen
MKKS McKusick-Kaufman syndrome
MNS1 meiosis-specific nuclear structural 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPS31 mitochondrial ribosomal protein S31
NELFE negative elongation factor complex member E
NOL8 nucleolar protein 8
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCF11 PCF11 cleavage and polyadenylation factor subunit
POLI polymerase (DNA directed) iota
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRR15L proline rich 15-like
PRR3 proline rich 3
PTCD2 pentatricopeptide repeat domain 2
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
RPP40 ribonuclease P/MRP 40kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
RUFY2 RUN and FYVE domain containing 2
RWDD2A RWD domain containing 2A
SALL2 spalt-like transcription factor 2
SAV1 salvador family WW domain containing protein 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPC25 SPC25, NDC80 kinetochore complex component
STARD7 StAR-related lipid transfer (START) domain containing 7
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYT17 synaptotagmin XVII
TBC1D31 TBC1 domain family, member 31
TFB1M transcription factor B1, mitochondrial
THAP7 THAP domain containing 7
TMEM177 transmembrane protein 177
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM27 tripartite motif containing 27
TRIM45 tripartite motif containing 45
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WDR3 WD repeat domain 3
WDR5B WD repeat domain 5B
XBP1 X-box binding protein 1
ZBED8 zinc finger, BED-type containing 8
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZMYM3 zinc finger, MYM-type 3
ZNF133 zinc finger protein 133
ZNF184 zinc finger protein 184
ZNF23 zinc finger protein 23
ZNF239 zinc finger protein 239
ZNF248 zinc finger protein 248
ZNF302 zinc finger protein 302
ZSCAN9 zinc finger and SCAN domain containing 9
ZXDC ZXD family zinc finger C