pronetalol-7322 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pronetalol-7322 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM22 ADAM metallopeptidase domain 22
ADAM8 ADAM metallopeptidase domain 8
ADCY9 adenylate cyclase 9
ADRBK2 adrenergic, beta, receptor kinase 2
AGMAT agmatine ureohydrolase (agmatinase)
AKAP7 A kinase (PRKA) anchor protein 7
ALDOB aldolase B, fructose-bisphosphate
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP9A ATPase, class II, type 9A
ATXN2L ataxin 2-like
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C19ORF73 chromosome 19 open reading frame 73
CA5BP1 carbonic anhydrase VB pseudogene 1
CACFD1 calcium channel flower domain containing 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CENPO centromere protein O
COL11A2 collagen, type XI, alpha 2
CPQ carboxypeptidase Q
CSF1R colony stimulating factor 1 receptor
CYHR1 cysteine/histidine-rich 1
CYLD cylindromatosis (turban tumor syndrome)
DCTN1 dynactin 1
DLC1 DLC1 Rho GTPase activating protein
DTNA dystrobrevin, alpha
EFNA3 ephrin-A3
EMC3 ER membrane protein complex subunit 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EVI2B ecotropic viral integration site 2B
EZR ezrin
FBLN1 fibulin 1
FBXO2 F-box protein 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GOLGA2 golgin A2
GRK5 G protein-coupled receptor kinase 5
GSPT1 G1 to S phase transition 1
HYAL4 hyaluronoglucosaminidase 4
IGHA1 immunoglobulin heavy constant alpha 1
IL23A interleukin 23, alpha subunit p19
INHBE inhibin, beta E
INTS7 integrator complex subunit 7
KRT83 keratin 83, type II
LDB3 LIM domain binding 3
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP13 matrix metallopeptidase 13
MTRF1L mitochondrial translational release factor 1-like
MUC2 mucin 2, oligomeric mucus/gel-forming
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCLN nicalin
NF1 neurofibromin 1
NKX3-2 NK3 homeobox 2
NME5 NME/NM23 family member 5
NR2F1 nuclear receptor subfamily 2, group F, member 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PHF20 PHD finger protein 20
POU6F1 POU class 6 homeobox 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
RASL11B RAS-like, family 11, member B
RGS12 regulator of G-protein signaling 12
RIF1 replication timing regulatory factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SECTM1 secreted and transmembrane 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK2 salt-inducible kinase 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLMO1 slowmo homolog 1 (Drosophila)
SOX12 SRY (sex determining region Y)-box 12
SSPN sarcospan
STK17B serine/threonine kinase 17b
SUGP1 SURP and G patch domain containing 1
TCHH trichohyalin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM2D1 TM2 domain containing 1
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRIB2 tribbles pseudokinase 2
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WDR4 WD repeat domain 4
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB33 zinc finger and BTB domain containing 33
ZNF286A zinc finger protein 286A
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC6 armadillo repeat containing 6
AXIN1 axin 1
BCL9 B-cell CLL/lymphoma 9
BMP4 bone morphogenetic protein 4
BRPF1 bromodomain and PHD finger containing, 1
C14ORF132 chromosome 14 open reading frame 132
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC170 coiled-coil domain containing 170
CCDC85C coiled-coil domain containing 85C
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEP131 centrosomal protein 131kDa
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCF1 cardiotrophin-like cytokine factor 1
CLDN15 claudin 15
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTAGE9 CTAGE family, member 9
DCAF13 DDB1 and CUL4 associated factor 13
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAL4 dynein, axonemal, light chain 4
ETAA1 Ewing tumor-associated antigen 1
FANCE Fanconi anemia, complementation group E
FBXL6 F-box and leucine-rich repeat protein 6
FCHO1 FCH domain only 1
FKBP10 FK506 binding protein 10, 65 kDa
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GLB1L2 galactosidase, beta 1-like 2
GLI3 GLI family zinc finger 3
GRB7 growth factor receptor-bound protein 7
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2BC histone cluster 1, H2bc
HIST1H2BE histone cluster 1, H2be
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSPA2 heat shock 70kDa protein 2
IL17RA interleukin 17 receptor A
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KDM8 lysine (K)-specific demethylase 8
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMB3 laminin, beta 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBTPS2 membrane-bound transcription factor peptidase, site 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFSD11 major facilitator superfamily domain containing 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTRF1 mitochondrial translational release factor 1
NDE1 nudE neurodevelopment protein 1
NFE2L3 nuclear factor, erythroid 2-like 3
ONECUT2 one cut homeobox 2
OTUD3 OTU deubiquitinase 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PDGFRL platelet-derived growth factor receptor-like
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRICKLE3 prickle homolog 3 (Drosophila)
RNF19B ring finger protein 19B
RNF25 ring finger protein 25
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SDC3 syndecan 3
SETD8 SET domain containing (lysine methyltransferase) 8
SNIP1 Smad nuclear interacting protein 1
SPAG7 sperm associated antigen 7
SPHK1 sphingosine kinase 1
SRD5A3 steroid 5 alpha-reductase 3
SREK1IP1 SREK1-interacting protein 1
TAOK1 TAO kinase 1
TMEM110 transmembrane protein 110
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TPCN1 two pore segment channel 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRAPPC2 trafficking protein particle complex 2
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
YEATS2 YEATS domain containing 2
ZMAT5 zinc finger, matrin-type 5
ZNF428 zinc finger protein 428
ZNF768 zinc finger protein 768
ZNF862 zinc finger protein 862
ZSCAN26 zinc finger and SCAN domain containing 26