prolonged qt interval Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave (Mammalian Phenotype Ontology, MP_0003233)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001657
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Genes

69 genes associated with the prolonged qt interval phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.51121
CNOT1 CCR4-NOT transcription complex, subunit 1 2.10659
CEP85L centrosomal protein 85kDa-like 2.04042
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.84227
RNF207 ring finger protein 207 1.81736
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.75033
SCN5A sodium channel, voltage gated, type V alpha subunit 1.68604
LIG3 ligase III, DNA, ATP-dependent 1.5239
FADS1 fatty acid desaturase 1 1.1838
C18ORF21 chromosome 18 open reading frame 21 1.09906
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) 1.08774
DPT dermatopontin 1.08558
ARHGAP10 Rho GTPase activating protein 10 1.0674
TMEM44 transmembrane protein 44 1.0674
PTPRG protein tyrosine phosphatase, receptor type, G 1.05869
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 1.04774
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.04365
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.04365
ELMO1 engulfment and cell motility 1 1.00059
NRG3 neuregulin 3 1.00059
CLDN15 claudin 15 1.00059
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.00059
NUBPL nucleotide binding protein-like 1.00059
TTN titin 1.00059
IL5RA interleukin 5 receptor, alpha 1.00059
SLCO3A1 solute carrier organic anion transporter family, member 3A1 1.00059
CELF4 CUGBP, Elav-like family member 4 0.969142
OSBPL6 oxysterol binding protein-like 6 0.969142
PALLD palladin, cytoskeletal associated protein 0.969142
CERKL ceramide kinase-like 0.969142
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 0.969142
CCND2 cyclin D2 0.942765
PDZRN3 PDZ domain containing ring finger 3 0.942765
CNTNAP2 contactin associated protein-like 2 0.942765
CLDN14 claudin 14 0.919744
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.899912
FOXP1 forkhead box P1 0.899912
LDB2 LIM domain binding 2 0.882984
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.868241
ADAMTSL1 ADAMTS-like 1 0.868241
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.868241
PRKCE protein kinase C, epsilon 0.868241
FGF14 fibroblast growth factor 14 0.868241
CREBBP CREB binding protein 0.855449
MBP myelin basic protein 0.855449
NME7 NME/NM23 family member 7 0.845939
NUAK1 NUAK family, SNF1-like kinase, 1 0.845831
UNC13C unc-13 homolog C (C. elegans) 0.845086
FRMD6 FERM domain containing 6 0.844241
NCOA2 nuclear receptor coactivator 2 0.823019
NKX2-5 NK2 homeobox 5 0.758788
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.721344
AJAP1 adherens junctions associated protein 1 0.697346
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.682533
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.643425
SOX5 SRY (sex determining region Y)-box 5 0.624461
TUSC3 tumor suppressor candidate 3 0.62227
CORIN corin, serine peptidase 0.571756
C11ORF21 chromosome 11 open reading frame 21 0.545167
USP31 ubiquitin specific peptidase 31 0.54245
TCEA3 transcription elongation factor A (SII), 3 0.533704
LPP LIM domain containing preferred translocation partner in lipoma 0.530515
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.483588
SLC22A23 solute carrier family 22, member 23 0.474018
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.462619
ASTN1 astrotactin 1 0.46012
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.453036
AKAP6 A kinase (PRKA) anchor protein 6 0.447717
LYRM4 LYR motif containing 4 0.447009