progressive supranuclear palsy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain. (Human Disease Ontology, DOID_678)
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Genes

157 genes co-occuring with the disease progressive supranuclear palsy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MAPT microtubule-associated protein tau 2.66048
CBS cystathionine-beta-synthase 1.94219
GRN granulin 1.67955
HIST1H1C histone cluster 1, H1c 1.67322
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.53172
TARDBP TAR DNA binding protein 1.42498
STX6 syntaxin 6 1.39433
RD3 retinal degeneration 3 1.39171
C9ORF72 chromosome 9 open reading frame 72 1.30052
FUS FUS RNA binding protein 1.27606
CHMP2B charged multivesicular body protein 2B 1.24428
MOBP myelin-associated oligodendrocyte basic protein 1.23646
PORCN porcupine homolog (Drosophila) 1.149
APOE apolipoprotein E 1.14051
KANSL1 KAT8 regulatory NSL complex subunit 1 1.12319
HIST1H1E histone cluster 1, H1e 1.11477
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene 1.00668
PHF1 PHD finger protein 1 0.957033
IGLON5 IgLON family member 5 0.954108
CHAT choline O-acetyltransferase 0.948685
LRRK2 leucine-rich repeat kinase 2 0.929173
CRYAB crystallin, alpha B 0.922974
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.917611
VCP valosin containing protein 0.90732
TAGLN3 transgelin 3 0.876966
LRRC37A3 leucine rich repeat containing 37, member A3 0.867549
LRRC37A leucine rich repeat containing 37A 0.867549
TH tyrosine hydroxylase 0.855268
DCTN1 dynactin 1 0.850354
CRHR1 corticotropin releasing hormone receptor 1 0.836017
MAP2 microtubule-associated protein 2 0.825768
MAP4 microtubule-associated protein 4 0.816745
SPPL2C signal peptide peptidase like 2C 0.787623
ACHE acetylcholinesterase (Yt blood group) 0.781479
DRD2 dopamine receptor D2 0.729357
FXYD3 FXYD domain containing ion transport regulator 3 0.727738
PSPC1 paraspeckle component 1 0.717232
CRABP2 cellular retinoic acid binding protein 2 0.716021
GSK3A glycogen synthase kinase 3 alpha 0.678701
BCHE butyrylcholinesterase 0.674315
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.661594
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.658026
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.641039
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.639857
ADNP activity-dependent neuroprotector homeobox 0.635528
ATXN2 ataxin 2 0.628457
CSNK1D casein kinase 1, delta 0.61866
FTL ferritin, light polypeptide 0.593674
SRSF10 serine/arginine-rich splicing factor 10 0.593674
FTH1 ferritin, heavy polypeptide 1 0.593285
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.580828
UBB ubiquitin B 0.580439
CDK5 cyclin-dependent kinase 5 0.570718
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.562558
NTS neurotensin 0.557509
SGSH N-sulfoglucosamine sulfohydrolase 0.554403
SAMD9 sterile alpha motif domain containing 9 0.541992
SNCAIP synuclein, alpha interacting protein 0.53928
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.525746
SFTPC surfactant protein C 0.508808
MMRN1 multimerin 1 0.496939
APP amyloid beta (A4) precursor protein 0.493122
TGM1 transglutaminase 1 0.489691
PVALB parvalbumin 0.487788
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.471846
TRA2B transformer 2 beta homolog (Drosophila) 0.471089
PANK2 pantothenate kinase 2 0.467306
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.465794
RPS26 ribosomal protein S26 0.465416
MAPK13 mitogen-activated protein kinase 13 0.457487
HTT huntingtin 0.452585
PSEN1 presenilin 1 0.445429
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.436026
PARK7 parkinson protein 7 0.424765
CDK13 cyclin-dependent kinase 13 0.402318
NGF nerve growth factor (beta polypeptide) 0.401572
HIST1H1B histone cluster 1, H1b 0.396353
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.393374
TGM2 transglutaminase 2 0.391141
MAP6 microtubule-associated protein 6 0.387794
GSK3B glycogen synthase kinase 3 beta 0.386308
TMEM106B transmembrane protein 106B 0.379256
GAN gigaxonin 0.377402
CTBS chitobiase, di-N-acetyl- 0.374809
MAOB monoamine oxidase B 0.373328
PARK2 parkin RBR E3 ubiquitin protein ligase 0.370368
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.369628
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.36704
TPPP tubulin polymerization promoting protein 0.36187
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.361502
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.359289
SYP synaptophysin 0.356709
FKBP4 FK506 binding protein 4, 59kDa 0.354499
HMOX1 heme oxygenase 1 0.350084
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.347879
SOD2 superoxide dismutase 2, mitochondrial 0.345675
TREM2 triggering receptor expressed on myeloid cells 2 0.344207
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.331391
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.32701
NEFH neurofilament, heavy polypeptide 0.318635
ADCY3 adenylate cyclase 3 0.312102
ACO2 aconitase 2, mitochondrial 0.308118
PTBP2 polypyrimidine tract binding protein 2 0.305948
ACP2 acid phosphatase 2, lysosomal 0.303781
PRNP prion protein 0.30342
COPS2 COP9 signalosome subunit 2 0.301254
PNMA2 paraneoplastic Ma antigen 2 0.300894
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.300173
ELANE elastase, neutrophil expressed 0.299452
AMD1 adenosylmethionine decarboxylase 1 0.296931
FBXO7 F-box protein 7 0.296211
PANK1 pantothenate kinase 1 0.289386
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.289386
C1QB complement component 1, q subcomponent, B chain 0.28831
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.276514
MYO6 myosin VI 0.270819
WNT3 wingless-type MMTV integration site family, member 3 0.266913
NPC1 Niemann-Pick disease, type C1 0.262306
SQSTM1 sequestosome 1 0.260891
GCH1 GTP cyclohydrolase 1 0.255241
ANPEP alanyl (membrane) aminopeptidase 0.251366
LRG1 leucine-rich alpha-2-glycoprotein 1 0.250311
MAPK14 mitogen-activated protein kinase 14 0.247852
PNMA1 paraneoplastic Ma antigen 1 0.245396
PHF6 PHD finger protein 6 0.245046
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.242245
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.242245
RNF31 ring finger protein 31 0.23945
HCRT hypocretin (orexin) neuropeptide precursor 0.236312
TPH1 tryptophan hydroxylase 1 0.229024
GFAP glial fibrillary acidic protein 0.221108
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.215314
MIR96 microRNA 96 0.214636
MIR137 microRNA 137 0.214636
ZFPM1 zinc finger protein, FOG family member 1 0.208245
ATG4C autophagy related 4C, cysteine peptidase 0.20658
GPR15 G protein-coupled receptor 15 0.205585
MT3 metallothionein 3 0.205254
ALDOA aldolase A, fructose-bisphosphate 0.200982
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.198386
TFCP2 transcription factor CP2 0.19582
DDB2 damage-specific DNA binding protein 2, 48kDa 0.191097
PDHX pyruvate dehydrogenase complex, component X 0.190786
CA4 carbonic anhydrase IV 0.182957
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.182375
EN1 engrailed homeobox 1 0.180652
CHGB chromogranin B 0.175146
ATP13A2 ATPase type 13A2 0.174617
MBP myelin basic protein 0.173832
BCO1 beta-carotene oxygenase 1 0.172544
OMD osteomodulin 0.171785
AZU1 azurocidin 1 0.170789
NRCAM neuronal cell adhesion molecule 0.169571
CALB1 calbindin 1, 28kDa 0.165874
SNAP23 synaptosomal-associated protein, 23kDa 0.163729
PITX3 paired-like homeodomain 3 0.161716
CLDN11 claudin 11 0.158097