progressive multifocal leukoencephalopathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. (Human Disease Ontology, DOID_643)
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Genes

87 genes co-occuring with the disease progressive multifocal leukoencephalopathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MXD4 MAX dimerization protein 4 2.1655
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.88713
CD4 CD4 molecule 1.86506
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 1.69587
TICAM2 toll-like receptor adaptor molecule 2 1.56711
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 1.49921
IFNB1 interferon, beta 1, fibroblast 1.45968
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 1.40439
CARTPT CART prepropeptide 1.18798
TAT tyrosine aminotransferase 1.11141
NFIA nuclear factor I/A 1.05471
NFIB nuclear factor I/B 1.03998
MBP myelin basic protein 1.00457
IGBP1 immunoglobulin (CD79A) binding protein 1 0.980531
CTXN2 cortexin 2 0.929587
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.922149
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.919261
CCNT1 cyclin T1 0.856087
RBM23 RNA binding motif protein 23 0.838476
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.790492
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.775341
EIF6 eukaryotic translation initiation factor 6 0.768801
IGHMBP2 immunoglobulin mu binding protein 2 0.699116
TP53 tumor protein p53 0.698313
BAG3 BCL2-associated athanogene 3 0.637889
NF1 neurofibromin 1 0.622575
FXYD1 FXYD domain containing ion transport regulator 1 0.613183
PURA purine-rich element binding protein A 0.597181
IL7 interleukin 7 0.591727
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.55945
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.533861
SRPR signal recognition particle receptor (docking protein) 0.52729
MAG myelin associated glycoprotein 0.514956
FOXH1 forkhead box H1 0.510728
CBX5 chromobox homolog 5 0.509192
CD19 CD19 molecule 0.502292
BAG1 BCL2-associated athanogene 0.48893
MARS methionyl-tRNA synthetase 0.480566
LBR lamin B receptor 0.476014
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.42814
COPS2 COP9 signalosome subunit 2 0.425514
TNF tumor necrosis factor 0.42289
SRSF1 serine/arginine-rich splicing factor 1 0.416521
POU2AF1 POU class 2 associating factor 1 0.415024
EPS15 epidermal growth factor receptor pathway substrate 15 0.410161
CXCL5 chemokine (C-X-C motif) ligand 5 0.396725
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.379626
TOP1 topoisomerase (DNA) I 0.372587
CD68 CD68 molecule 0.352291
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.346042
CD34 CD34 molecule 0.345308
ACTG1 actin gamma 1 0.328834
VPREB1 pre-B lymphocyte 1 0.324094
IL2 interleukin 2 0.321545
CXCL6 chemokine (C-X-C motif) ligand 6 0.320454
SSBP3 single stranded DNA binding protein 3 0.305948
CDK2 cyclin-dependent kinase 2 0.303781
SOX11 SRY (sex determining region Y)-box 11 0.295492
CD52 CD52 molecule 0.292616
OPRK1 opioid receptor, kappa 1 0.283655
CCR8 chemokine (C-C motif) receptor 8 0.274021
ALOX5 arachidonate 5-lipoxygenase 0.269043
MLX MLX, MAX dimerization protein 0.26514
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.248554
SPAG9 sperm associated antigen 9 0.246098
RAD51 RAD51 recombinase 0.237706
CCL13 chemokine (C-C motif) ligand 13 0.222136
HLA-A major histocompatibility complex, class I, A 0.21974
CDK9 cyclin-dependent kinase 9 0.215992
MEGF6 multiple EGF-like-domains 6 0.211597
DAND5 DAN domain family member 5, BMP antagonist 0.211261
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.208245
NAPSA napsin A aspartic peptidase 0.203275
PML promyelocytic leukemia 0.202618
GFAP glial fibrillary acidic protein 0.200982
TGFB2 transforming growth factor, beta 2 0.198709
CCR7 chemokine (C-C motif) receptor 7 0.198064
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.187719
SELL selectin L 0.18651
MECP2 methyl CpG binding protein 2 0.183248
PCNA proliferating cell nuclear antigen 0.178682
SP100 SP100 nuclear antigen 0.178403
CD247 CD247 molecule 0.172038
SALL4 spalt-like transcription factor 4 0.170789
CD40LG CD40 ligand 0.170054
IL2RG interleukin 2 receptor, gamma 0.166995
CCNB1 cyclin B1 0.162908