profenamine-3038 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the profenamine-3038 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMELX amelogenin, X-linked
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
ATN1 atrophin 1
BMP7 bone morphogenetic protein 7
C1ORF105 chromosome 1 open reading frame 105
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CAV2 caveolin 2
CD248 CD248 molecule, endosialin
CFAP70 cilia and flagella associated protein 70
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL17A1 collagen, type XVII, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPZ carboxypeptidase Z
CREBBP CREB binding protein
CSN2 casein beta
CSN3 casein kappa
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAGLA diacylglycerol lipase, alpha
DLL3 delta-like 3 (Drosophila)
DPYSL4 dihydropyrimidinase-like 4
EDDM3A epididymal protein 3A
EFNA5 ephrin-A5
ERBB3 erb-b2 receptor tyrosine kinase 3
EYA2 EYA transcriptional coactivator and phosphatase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FOXE1 forkhead box E1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZD10 frizzled class receptor 10
FZD4 frizzled class receptor 4
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GPR157 G protein-coupled receptor 157
GTPBP1 GTP binding protein 1
GVINP1 GTPase, very large interferon inducible pseudogene 1
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HOXB6 homeobox B6
HRASLS2 HRAS-like suppressor 2
IL2RA interleukin 2 receptor, alpha
ITGB4 integrin, beta 4
KAT8 K(lysine) acetyltransferase 8
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA1045 KIAA1045
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP1A microtubule-associated protein 1A
MBP myelin basic protein
MCF2 MCF.2 cell line derived transforming sequence
MPPE1 metallophosphoesterase 1
MTSS1 metastasis suppressor 1
MVD mevalonate (diphospho) decarboxylase
MYH14 myosin, heavy chain 14, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCKAP1 NCK-associated protein 1
NES nestin
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRCAM neuronal cell adhesion molecule
PDE4DIP phosphodiesterase 4D interacting protein
PKNOX1 PBX/knotted 1 homeobox 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PQBP1 polyglutamine binding protein 1
PRM2 protamine 2
PRO2964 uncharacterized protein PRO2964
PTGDR2 prostaglandin D2 receptor 2
PYY peptide YY
RAB26 RAB26, member RAS oncogene family
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCIN scinderin
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNPH syntaphilin
SORBS2 sorbin and SH3 domain containing 2
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYCP1 synaptonemal complex protein 1
TBX6 T-box 6
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLX3 T-cell leukemia homeobox 3
TRIM3 tripartite motif containing 3
TRO trophinin
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UNC93A unc-93 homolog A (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ACPP acid phosphatase, prostate
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AOAH acyloxyacyl hydrolase (neutrophil)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL15 ADP-ribosylation factor-like 15
BAMBI BMP and activin membrane-bound inhibitor
BANK1 B-cell scaffold protein with ankyrin repeats 1
C11ORF30 chromosome 11 open reading frame 30
C14ORF93 chromosome 14 open reading frame 93
C8ORF44 chromosome 8 open reading frame 44
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CCRL2 chemokine (C-C motif) receptor-like 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CELP carboxyl ester lipase pseudogene
CEP295 centrosomal protein 295kDa
CFP complement factor properdin
CGREF1 cell growth regulator with EF-hand domain 1
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DOCK4 dedicator of cytokinesis 4
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EGR2 early growth response 2
FHL3 four and a half LIM domains 3
FLT4 fms-related tyrosine kinase 4
FOXD1 forkhead box D1
FRS3 fibroblast growth factor receptor substrate 3
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GIPC1 GIPC PDZ domain containing family, member 1
GLCE glucuronic acid epimerase
GPATCH2L G patch domain containing 2-like
GSDMD gasdermin D
HHLA3 HERV-H LTR-associating 3
HIST1H1B histone cluster 1, H1b
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HRAS Harvey rat sarcoma viral oncogene homolog
IBSP integrin-binding sialoprotein
IFI30 interferon, gamma-inducible protein 30
IFT81 intraflagellar transport 81
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL11RA interleukin 11 receptor, alpha
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
LZTR1 leucine-zipper-like transcription regulator 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MTSS1L metastasis suppressor 1-like
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NIPAL2 NIPA-like domain containing 2
NME8 NME/NM23 family member 8
NOL10 nucleolar protein 10
NTSR1 neurotensin receptor 1 (high affinity)
OXCT2 3-oxoacid CoA transferase 2
PARP16 poly (ADP-ribose) polymerase family, member 16
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PRSS53 protease, serine, 53
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRS protein tyrosine phosphatase, receptor type, S
RARS arginyl-tRNA synthetase
RBL1 retinoblastoma-like 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS13 regulator of G-protein signaling 13
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN2 Ras and Rab interactor 2
RPGRIP1L RPGRIP1-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SAV1 salvador family WW domain containing protein 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35F5 solute carrier family 35, member F5
SLITRK5 SLIT and NTRK-like family, member 5
SNIP1 Smad nuclear interacting protein 1
SPATA20 spermatogenesis associated 20
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIAM2 T-cell lymphoma invasion and metastasis 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM120B transmembrane protein 120B
TMEM19 transmembrane protein 19
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPS1 trichorhinophalangeal syndrome I
TUFT1 tuftelin 1
XAB2 XPA binding protein 2
YOD1 YOD1 deubiquitinase
ZDHHC14 zinc finger, DHHC-type containing 14
ZMAT3 zinc finger, matrin-type 3
ZNF354A zinc finger protein 354A
ZNF768 zinc finger protein 768