prochlorperazine-455 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the prochlorperazine-455 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF1 AF4/FMR2 family, member 1
AGMAT agmatine ureohydrolase (agmatinase)
AKAP13 A kinase (PRKA) anchor protein 13
AMBRA1 autophagy/beclin-1 regulator 1
APCS amyloid P component, serum
ATXN2 ataxin 2
ATXN2L ataxin 2-like
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C16ORF62 chromosome 16 open reading frame 62
C5ORF45 chromosome 5 open reading frame 45
CA12 carbonic anhydrase XII
CCDC176 coiled-coil domain containing 176
CCNG2 cyclin G2
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEP76 centrosomal protein 76kDa
CHMP1B charged multivesicular body protein 1B
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNTFR ciliary neurotrophic factor receptor
COBL cordon-bleu WH2 repeat protein
COX5B cytochrome c oxidase subunit Vb
CSH2 chorionic somatomammotropin hormone 2
CSN2 casein beta
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPY19L1 dpy-19-like 1 (C. elegans)
DRP2 dystrophin related protein 2
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
FAM110B family with sequence similarity 110, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GAB2 GRB2-associated binding protein 2
GAS7 growth arrest-specific 7
GATAD1 GATA zinc finger domain containing 1
GP2 glycoprotein 2 (zymogen granule membrane)
GRIP2 glutamate receptor interacting protein 2
HECA headcase homolog (Drosophila)
HIST3H2A histone cluster 3, H2a
HLA-G major histocompatibility complex, class I, G
HPGDS hematopoietic prostaglandin D synthase
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
ILK integrin-linked kinase
INSIG1 insulin induced gene 1
KIAA0141 KIAA0141
KIF5B kinesin family member 5B
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MBNL2 muscleblind-like splicing regulator 2
MFAP2 microfibrillar-associated protein 2
MNT MAX network transcriptional repressor
MST1 macrophage stimulating 1
MVK mevalonate kinase
MXD4 MAX dimerization protein 4
MYL12B myosin, light chain 12B, regulatory
MZF1 myeloid zinc finger 1
NCR1 natural cytotoxicity triggering receptor 1
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NIPAL2 NIPA-like domain containing 2
NOP16 NOP16 nucleolar protein
NPPA natriuretic peptide A
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP160 nucleoporin 160kDa
PAIP2B poly(A) binding protein interacting protein 2B
PCSK7 proprotein convertase subtilisin/kexin type 7
PILRB paired immunoglobin-like type 2 receptor beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PNRC1 proline-rich nuclear receptor coactivator 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRG3 proteoglycan 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RABGAP1 RAB GTPase activating protein 1
RNF44 ring finger protein 44
RPS11 ribosomal protein S11
RUNDC3A RUN domain containing 3A
SBNO2 strawberry notch homolog 2 (Drosophila)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFRP4 secreted frizzled-related protein 4
SFTPC surfactant protein C
SFXN3 sideroflexin 3
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SMAD3 SMAD family member 3
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TCF3 transcription factor 3
TCP11L1 t-complex 11, testis-specific-like 1
TMPRSS2 transmembrane protease, serine 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I11 tumor protein p53 inducible protein 11
TRAF4 TNF receptor-associated factor 4
TRIM33 tripartite motif containing 33
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VGLL4 vestigial-like family member 4
ZFP36 ZFP36 ring finger protein
ZNF335 zinc finger protein 335

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ASB9 ankyrin repeat and SOCS box containing 9
ATXN8OS ATXN8 opposite strand (non-protein coding)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BMP10 bone morphogenetic protein 10
C2CD2 C2 calcium-dependent domain containing 2
CALB2 calbindin 2
CAV3 caveolin 3
CCDC91 coiled-coil domain containing 91
CD300C CD300c molecule
CHD2 chromodomain helicase DNA binding protein 2
CIDEB cell death-inducing DFFA-like effector b
CPTP ceramide-1-phosphate transfer protein
CRIP2 cysteine-rich protein 2
CRYAB crystallin, alpha B
CYB5R3 cytochrome b5 reductase 3
DAAM2 dishevelled associated activator of morphogenesis 2
DCAF10 DDB1 and CUL4 associated factor 10
DCSTAMP dendrocyte expressed seven transmembrane protein
DIO3 deiodinase, iodothyronine, type III
DNAI1 dynein, axonemal, intermediate chain 1
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTX4 deltex 4, E3 ubiquitin ligase
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGFL6 EGF-like-domain, multiple 6
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM86C1 family with sequence similarity 86, member C1
FASTKD3 FAST kinase domains 3
FBXO5 F-box protein 5
FGFBP1 fibroblast growth factor binding protein 1
FHL3 four and a half LIM domains 3
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXC1 forkhead box C1
FOXD1 forkhead box D1
FOXI1 forkhead box I1
GRWD1 glutamate-rich WD repeat containing 1
HCG9 HLA complex group 9 (non-protein coding)
HIST1H1C histone cluster 1, H1c
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KRT1 keratin 1, type II
LRRC20 leucine rich repeat containing 20
LRRC49 leucine rich repeat containing 49
LZTS3 leucine zipper, putative tumor suppressor family member 3
MATK megakaryocyte-associated tyrosine kinase
MGC2889 uncharacterized protein MGC2889
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MOXD1 monooxygenase, DBH-like 1
MRPL12 mitochondrial ribosomal protein L12
MRPL44 mitochondrial ribosomal protein L44
MSX1 msh homeobox 1
NCS1 neuronal calcium sensor 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
ODF2 outer dense fiber of sperm tails 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAK1IP1 PAK1 interacting protein 1
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLA2G12A phospholipase A2, group XIIA
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PQLC3 PQ loop repeat containing 3
PRF1 perforin 1 (pore forming protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSAT1 phosphoserine aminotransferase 1
RANBP6 RAN binding protein 6
RIPPLY3 ripply transcriptional repressor 3
RNF39 ring finger protein 39
S100A1 S100 calcium binding protein A1
SDC3 syndecan 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SLC17A4 solute carrier family 17, member 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SURF2 surfeit 2
SYT2 synaptotagmin II
TAGLN transgelin
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TET3 tet methylcytosine dioxygenase 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM115 transmembrane protein 115
TMEM176A transmembrane protein 176A
TMEM53 transmembrane protein 53
TMPRSS5 transmembrane protease, serine 5
TP53BP1 tumor protein p53 binding protein 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UNC93B1 unc-93 homolog B1 (C. elegans)
WNT16 wingless-type MMTV integration site family, member 16
ZNF652 zinc finger protein 652
ZNF668 zinc finger protein 668
ZNF7 zinc finger protein 7