prochlorperazine-2675 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the prochlorperazine-2675 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
C17ORF59 chromosome 17 open reading frame 59
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD83 CD83 molecule
CD86 CD86 molecule
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CRNN cornulin
CXCL8 chemokine (C-X-C motif) ligand 8
DNAH7 dynein, axonemal, heavy chain 7
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNMBP dynamin binding protein
DOPEY1 dopey family member 1
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM114A1 family with sequence similarity 114, member A1
FCMR Fc fragment of IgM receptor
FLOT1 flotillin 1
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GNLY granulysin
GOLGA2 golgin A2
HIPK3 homeodomain interacting protein kinase 3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL24 interleukin 24
IL3RA interleukin 3 receptor, alpha (low affinity)
INCENP inner centromere protein antigens 135/155kDa
ING2 inhibitor of growth family, member 2
INHBA inhibin, beta A
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LHFPL2 lipoma HMGIC fusion partner-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MTUS1 microtubule associated tumor suppressor 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP2 neuropilin 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PHACTR1 phosphatase and actin regulator 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPAP2A phosphatidic acid phosphatase type 2A
PPARG peroxisome proliferator-activated receptor gamma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCI protein kinase C, iota
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SGK1 serum/glucocorticoid regulated kinase 1
SLAMF7 SLAM family member 7
SPP1 secreted phosphoprotein 1
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STON1 stonin 1
STX11 syntaxin 11
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TFF2 trefoil factor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB2A tubulin, beta 2A class IIa
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBTD1 ubiquitin domain containing 1
ULBP2 UL16 binding protein 2
VCAN versican

decreased expression

Symbol Name
ANXA3 annexin A3
AOAH acyloxyacyl hydrolase (neutrophil)
ASGR2 asialoglycoprotein receptor 2
BNC2 basonuclin 2
C1RL complement component 1, r subcomponent-like
C22ORF46 chromosome 22 open reading frame 46
C7ORF69 chromosome 7 open reading frame 69
C8A complement component 8, alpha polypeptide
C9ORF9 chromosome 9 open reading frame 9
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCDC106 coiled-coil domain containing 106
CCDC176 coiled-coil domain containing 176
CCR2 chemokine (C-C motif) receptor 2
CDHR2 cadherin-related family member 2
CEP70 centrosomal protein 70kDa
CGA glycoprotein hormones, alpha polypeptide
CLDN3 claudin 3
CLIP2 CAP-GLY domain containing linker protein 2
CNN1 calponin 1, basic, smooth muscle
CPNE7 copine VII
CRYL1 crystallin, lambda 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DDN dendrin
DEAF1 DEAF1 transcription factor
DSPP dentin sialophosphoprotein
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHB6 EPH receptor B6
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM86B1 family with sequence similarity 86, member B1
FBRS fibrosin
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FRMPD1 FERM and PDZ domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GAMT guanidinoacetate N-methyltransferase
GATA6 GATA binding protein 6
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRB7 growth factor receptor-bound protein 7
HAMP hepcidin antimicrobial peptide
HIST1H2BI histone cluster 1, H2bi
HIST1H2BN histone cluster 1, H2bn
HYAL2 hyaluronoglucosaminidase 2
ICK intestinal cell (MAK-like) kinase
IL1B interleukin 1, beta
KDM5C lysine (K)-specific demethylase 5C
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLF1 Kruppel-like factor 1 (erythroid)
KRT81 keratin 81, type II
LPPR3 lipid phosphate phosphatase-related protein type 3
LRRC20 leucine rich repeat containing 20
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MANSC1 MANSC domain containing 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MMP9 matrix metallopeptidase 9
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
NAG18 NAG18 mRNA
NFE2 nuclear factor, erythroid 2
OCLN occludin
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G15 phospholipase A2, group XV
PRKCZ protein kinase C, zeta
PYCRL pyrroline-5-carboxylate reductase-like
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIN2 Ras and Rab interactor 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A9 S100 calcium binding protein A9
S1PR4 sphingosine-1-phosphate receptor 4
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIDT1 SID1 transmembrane family, member 1
SIX3 SIX homeobox 3
SLC16A6 solute carrier family 16, member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLITRK5 SLIT and NTRK-like family, member 5
SPIDR scaffolding protein involved in DNA repair
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYTL2 synaptotagmin-like 2
TAGLN transgelin
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGM5 transglutaminase 5
THBS4 thrombospondin 4
TMEM212 transmembrane protein 212
TNNT1 troponin T type 1 (skeletal, slow)
TONSL tonsoku-like, DNA repair protein
TSC22D4 TSC22 domain family, member 4
TSPAN5 tetraspanin 5
TTLL1 tubulin tyrosine ligase-like family member 1
ZNF226 zinc finger protein 226
ZNF250 zinc finger protein 250