primidone-6723 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the primidone-6723 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
ADCY2 adenylate cyclase 2 (brain)
ADGRF5 adhesion G protein-coupled receptor F5
ANKRD12 ankyrin repeat domain 12
ARG2 arginase 2
ARR3 arrestin 3, retinal (X-arrestin)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B9D1 B9 protein domain 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QTNF3 C1q and tumor necrosis factor related protein 3
C4BPA complement component 4 binding protein, alpha
CD58 CD58 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDC14B cell division cycle 14B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEND1 cell cycle exit and neuronal differentiation 1
CFP complement factor properdin
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CISH cytokine inducible SH2-containing protein
COBL cordon-bleu WH2 repeat protein
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTSS cathepsin S
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFS embryonal Fyn-associated substrate
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPS8L1 EPS8-like 1
EZR ezrin
FAM131B family with sequence similarity 131, member B
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA4 GATA binding protein 4
GPATCH4 G patch domain containing 4
GPR21 G protein-coupled receptor 21
GUK1 guanylate kinase 1
HIST1H4F histone cluster 1, H4f
IER3IP1 immediate early response 3 interacting protein 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB5 integrin, beta 5
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA1467 KIAA1467
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
LAG3 lymphocyte-activation gene 3
LDLR low density lipoprotein receptor
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MED25 mediator complex subunit 25
MFAP3L microfibrillar-associated protein 3-like
MRPL52 mitochondrial ribosomal protein L52
MST1 macrophage stimulating 1
MYBPC3 myosin binding protein C, cardiac
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNAT neuronatin
NOVA2 neuro-oncological ventral antigen 2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OGFR opioid growth factor receptor
PADI1 peptidyl arginine deiminase, type I
PAOX polyamine oxidase (exo-N4-amino)
PDCD2 programmed cell death 2
PDLIM3 PDZ and LIM domain 3
PGK1 phosphoglycerate kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPARD peroxisome proliferator-activated receptor delta
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKG2 protein kinase, cGMP-dependent, type II
PSORS1C1 psoriasis susceptibility 1 candidate 1
RAB2A RAB2A, member RAS oncogene family
RHEB Ras homolog enriched in brain
RPL14 ribosomal protein L14
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SAP30 Sin3A-associated protein, 30kDa
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
STK17A serine/threonine kinase 17a
TAL1 T-cell acute lymphocytic leukemia 1
TBXA2R thromboxane A2 receptor
TGFB2 transforming growth factor, beta 2
TM6SF1 transmembrane 6 superfamily member 1
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
UNC93B1 unc-93 homolog B1 (C. elegans)
VWA5A von Willebrand factor A domain containing 5A
ZBTB20 zinc finger and BTB domain containing 20
ZC3H7B zinc finger CCCH-type containing 7B
ZNF268 zinc finger protein 268
ZNF573 zinc finger protein 573
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AES amino-terminal enhancer of split
AMDHD2 amidohydrolase domain containing 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAD5 ATPase family, AAA domain containing 5
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BRMS1 breast cancer metastasis suppressor 1
CALCOCO1 calcium binding and coiled-coil domain 1
CBX8 chromobox homolog 8
CEP85 centrosomal protein 85kDa
CHM choroideremia (Rab escort protein 1)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC2B C-type lectin domain family 2, member B
CNN2 calponin 2
CORO1A coronin, actin binding protein, 1A
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRABP2 cellular retinoic acid binding protein 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSD cathepsin D
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTN dematin actin binding protein
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB1 ephrin-B1
ELP3 elongator acetyltransferase complex subunit 3
EPHX2 epoxide hydrolase 2, cytoplasmic
EXOC5 exocyst complex component 5
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
FSD1 fibronectin type III and SPRY domain containing 1
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
H1F0 H1 histone family, member 0
HDAC7 histone deacetylase 7
HIST1H2BN histone cluster 1, H2bn
HIST1H3B histone cluster 1, H3b
HOMER2 homer scaffolding protein 2
HSPA1L heat shock 70kDa protein 1-like
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLC2 kinesin light chain 2
KLF13 Kruppel-like factor 13
KLF3 Kruppel-like factor 3 (basic)
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIME1 Lck interacting transmembrane adaptor 1
LPAR4 lysophosphatidic acid receptor 4
LRRC61 leucine rich repeat containing 61
LY6E lymphocyte antigen 6 complex, locus E
MBTPS2 membrane-bound transcription factor peptidase, site 2
MVP major vault protein
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
MYL5 myosin, light chain 5, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUPR1 nuclear protein, transcriptional regulator, 1
ODF2 outer dense fiber of sperm tails 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OVGP1 oviductal glycoprotein 1, 120kDa
PCOLCE procollagen C-endopeptidase enhancer
PDE8B phosphodiesterase 8B
PES1 pescadillo ribosomal biogenesis factor 1
PKM pyruvate kinase, muscle
PLD3 phospholipase D family, member 3
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRB3 proline-rich protein BstNI subfamily 3
PRICKLE3 prickle homolog 3 (Drosophila)
PTK7 protein tyrosine kinase 7 (inactive)
RAPSN receptor-associated protein of the synapse
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TEAD3 TEA domain family member 3
TEX40 testis expressed 40
TMEM121 transmembrane protein 121
ULBP2 UL16 binding protein 2
VEGFB vascular endothelial growth factor B
ZFHX3 zinc finger homeobox 3
ZNF286A zinc finger protein 286A
ZNF669 zinc finger protein 669