primary pulmonary hypertension Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling. (Human Disease Ontology, DOID_14557)
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Genes

124 genes co-occuring with the disease primary pulmonary hypertension in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.49857
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 1.43069
ATL3 atlastin GTPase 3 1.40526
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.11519
EDN1 endothelin 1 1.11393
G6PC3 glucose 6 phosphatase, catalytic, 3 0.986849
TGFB1 transforming growth factor, beta 1 0.97338
NPPA natriuretic peptide A 0.954525
EDNRA endothelin receptor type A 0.921736
ACVRL1 activin A receptor type II-like 1 0.871234
IGLV1-36 immunoglobulin lambda variable 1-36 0.829049
ACE angiotensin I converting enzyme 0.811411
BMP4 bone morphogenetic protein 4 0.791721
SMAD6 SMAD family member 6 0.760231
PDE5A phosphodiesterase 5A, cGMP-specific 0.711587
EXOC2 exocyst complex component 2 0.707157
IPO7 importin 7 0.701928
ADM adrenomedullin 0.699517
VWF von Willebrand factor 0.687091
BMP2 bone morphogenetic protein 2 0.682294
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.681495
CKAP4 cytoskeleton-associated protein 4 0.673518
HOXB2 homeobox B2 0.656046
MAP2K5 mitogen-activated protein kinase kinase 5 0.652484
HOXB6 homeobox B6 0.652484
THBD thrombomodulin 0.650903
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.649323
GRP gastrin-releasing peptide 0.622575
PDE9A phosphodiesterase 9A 0.571107
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.561004
NOS3 nitric oxide synthase 3 (endothelial cell) 0.557509
NCR3 natural cytotoxicity triggering receptor 3 0.541992
FBN1 fibrillin 1 0.536957
RTN4 reticulon 4 0.526132
ADCY2 adenylate cyclase 2 (brain) 0.523816
MME membrane metallo-endopeptidase 0.518805
PLAT plasminogen activator, tissue 0.513033
SMAD2 SMAD family member 2 0.504973
ERAS ES cell expressed Ras 0.504973
CALCA calcitonin-related polypeptide alpha 0.490072
F8 coagulation factor VIII, procoagulant component 0.488549
PLG plasminogen 0.488169
ADRB2 adrenoceptor beta 2, surface 0.486646
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.475634
OSTM1 osteopetrosis associated transmembrane protein 1 0.466928
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.449947
ACTC1 actin, alpha, cardiac muscle 1 0.447311
FNDC3A fibronectin type III domain containing 3A 0.42214
HOXA5 homeobox A5 0.405305
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.398589
TGFBR3 transforming growth factor, beta receptor III 0.398589
NPPB natriuretic peptide B 0.388909
BMP1 bone morphogenetic protein 1 0.388166
HMGB2 high mobility group box 2 0.385193
KNG1 kininogen 1 0.380739
ACTA2 actin, alpha 2, smooth muscle, aorta 0.379997
SMAD4 SMAD family member 4 0.379256
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.376661
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.374809
CLCN7 chloride channel, voltage-sensitive 7 0.372217
LHB luteinizing hormone beta polypeptide 0.36741
ACVR2A activin A receptor, type IIA 0.36704
GRAP2 GRB2-related adaptor protein 2 0.36704
HOXB7 homeobox B7 0.365562
LIMK1 LIM domain kinase 1 0.362978
RFC2 replication factor C (activator 1) 2, 40kDa 0.351187
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.347511
BMP7 bone morphogenetic protein 7 0.338341
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.332852
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.32774
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.324458
ACVR1 activin A receptor, type I 0.322637
PDLIM1 PDZ and LIM domain 1 0.318635
ACE2 angiotensin I converting enzyme 2 0.317545
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.313552
YME1L1 YME1-like 1 ATPase 0.308118
CCL3 chemokine (C-C motif) ligand 3 0.307033
DYNLT1 dynein, light chain, Tctex-type 1 0.301615
MLX MLX, MAX dimerization protein 0.301615
FBLIM1 filamin binding LIM protein 1 0.300894
CFL1 cofilin 1 (non-muscle) 0.300894
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.297651
PDGFA platelet-derived growth factor alpha polypeptide 0.296931
CYCS cytochrome c, somatic 0.293334
FLNB filamin B, beta 0.290821
MAOA monoamine oxidase A 0.290821
GZMM granzyme M (lymphocyte met-ase 1) 0.28294
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.277584
F3 coagulation factor III (thromboplastin, tissue factor) 0.272953
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.267977
HMGA2 high mobility group AT-hook 2 0.266203
CENPB centromere protein B, 80kDa 0.265494
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.256652
ALOX5 arachidonate 5-lipoxygenase 0.245747
SPINK5 serine peptidase inhibitor, Kazal type 5 0.238054
PTGIS prostaglandin I2 (prostacyclin) synthase 0.231448
GDF5 growth differentiation factor 5 0.229024
KLF6 Kruppel-like factor 6 0.22454
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.223509
RPSA ribosomal protein SA 0.217693
PROS1 protein S (alpha) 0.214975
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.212945
NDP Norrie disease (pseudoglioma) 0.210253
CASQ2 calsequestrin 2 (cardiac muscle) 0.210253
HTRA2 HtrA serine peptidase 2 0.206913
HLA-C major histocompatibility complex, class I, C 0.205585
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.204593
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.198709
HBA2 hemoglobin, alpha 2 0.198386
RYR2 ryanodine receptor 2 (cardiac) 0.192344
ECE1 endothelin converting enzyme 1 0.191719
STAT5A signal transducer and activator of transcription 5A 0.191719
EPHX2 epoxide hydrolase 2, cytoplasmic 0.188938
APEH acylaminoacyl-peptide hydrolase 0.182957
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.174617
STAT5B signal transducer and activator of transcription 5B 0.173571
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.173314
CAV1 caveolin 1, caveolae protein, 22kDa 0.173057
BMP6 bone morphogenetic protein 6 0.172291
NONO non-POU domain containing, octamer-binding 0.170054
VIP vasoactive intestinal peptide 0.165001
REN renin 0.162707
SCARB2 scavenger receptor class B, member 2 0.158605
GYPE glycophorin E (MNS blood group) 0.158097