primary open angle glaucoma Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_1070)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0012108
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Genes

65 genes associated with the primary open angle glaucoma phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
PTGER3 prostaglandin E receptor 3 (subtype EP3) 1.90394
CDKN2B-AS1 CDKN2B antisense RNA 1 1.88591
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.72215
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 1.5685
PLEKHA7 pleckstrin homology domain containing, family A member 7 1.52822
COL11A1 collagen, type XI, alpha 1 1.35901
CAV2 caveolin 2 1.35178
DCLK1 doublecortin-like kinase 1 1.24751
CHEK2 checkpoint kinase 2 1.24751
BCAS3 breast carcinoma amplified sequence 3 1.19958
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 1.18063
RERE arginine-glutamic acid dipeptide (RE) repeats 1.17192
LOXL1 lysyl oxidase-like 1 1.15953
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 1.1361
TXNRD2 thioredoxin reductase 2 1.12851
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.11203
CADPS Ca++-dependent secretion activator 1.06777
PRKCH protein kinase C, eta 1.03761
ZNF827 zinc finger protein 827 1.00488
ITPKB inositol-trisphosphate 3-kinase B 1.00286
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.984214
LOC643339 uncharacterized LOC643339 0.984214
SIX6 SIX homeobox 6 0.976676
PTPRD protein tyrosine phosphatase, receptor type, D 0.972518
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.969142
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.963603
PDE4D phosphodiesterase 4D, cAMP-specific 0.962153
RGS6 regulator of G-protein signaling 6 0.938611
PLB1 phospholipase B1 0.935362
CPB1 carboxypeptidase B1 (tissue) 0.926745
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.909045
ANKRD44 ankyrin repeat domain 44 0.860885
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.857387
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.849662
FOCAD focadhesin 0.844346
RCAN2 regulator of calcineurin 2 0.778318
WDR82 WD repeat domain 82 0.768701
CDKN2A cyclin-dependent kinase inhibitor 2A 0.750439
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.749505
FAM169B family with sequence similarity 169, member B 0.749505
DSTYK dual serine/threonine and tyrosine protein kinase 0.739827
RPSAP52 ribosomal protein SA pseudogene 52 0.702128
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.688736
NPAS3 neuronal PAS domain protein 3 0.684556
SRBD1 S1 RNA binding domain 1 0.682247
PARD3B par-3 family cell polarity regulator beta 0.675718
MTAP methylthioadenosine phosphorylase 0.659752
ZDHHC2 zinc finger, DHHC-type containing 2 0.648123
MAML2 mastermind-like 2 (Drosophila) 0.638234
SOD2 superoxide dismutase 2, mitochondrial 0.628362
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.621094
NWD2 NACHT and WD repeat domain containing 2 0.617271
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.616892
CDH13 cadherin 13 0.601932
LOC729911 0.599122
BBS9 Bardet-Biedl syndrome 9 0.597988
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.593421
PXDNL peroxidasin-like 0.59296
CSMD1 CUB and Sushi multiple domains 1 0.582458
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.531908
ZSWIM3 zinc finger, SWIM-type containing 3 0.522136
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.496801
GFAP glial fibrillary acidic protein 0.496025
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.448846
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.440822