presynaptic active zone Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix. (Gene Ontology, GO_0048786)
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Genes

204 proteins co-occuring with the presynaptic active zone cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BSN bassoon presynaptic cytomatrix protein 2.24589
RIMS1 regulating synaptic membrane exocytosis 1 1.6342
GPX5 glutathione peroxidase 5 1.61471
GPX4 glutathione peroxidase 4 1.60651
ERC1 ELKS/RAB6-interacting/CAST family member 1 1.60243
GPX1 glutathione peroxidase 1 1.59778
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.50114
SOD2 superoxide dismutase 2, mitochondrial 1.45873
CTBP2 C-terminal binding protein 2 1.45647
CAT catalase 1.45081
PCLO piccolo presynaptic cytomatrix protein 1.42936
UNC13A unc-13 homolog A (C. elegans) 1.40746
ERC2 ELKS/RAB6-interacting/CAST family member 2 1.36802
PHF20 PHD finger protein 20 1.15928
HSF4 heat shock transcription factor 4 1.15467
RIMS2 regulating synaptic membrane exocytosis 2 1.12705
UNC13B unc-13 homolog B (C. elegans) 1.12143
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 1.11939
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 1.09849
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.06094
LIF leukemia inhibitory factor 1.05236
GSR glutathione reductase 1.0104
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 1.00892
GRM7 glutamate receptor, metabotropic 7 0.998086
AANAT aralkylamine N-acetyltransferase 0.990736
TOB1 transducer of ERBB2, 1 0.962146
CABP4 calcium binding protein 4 0.918111
RIMS4 regulating synaptic membrane exocytosis 4 0.823123
PDZD11 PDZ domain containing 11 0.815781
CTBP1 C-terminal binding protein 1 0.784614
G6PD glucose-6-phosphate dehydrogenase 0.782326
OTOF otoferlin 0.777298
ZNF224 zinc finger protein 224 0.773188
KLK4 kallikrein-related peptidase 4 0.765893
SYP synaptophysin 0.75453
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.735115
DGCR14 DiGeorge syndrome critical region gene 14 0.703949
CPLX3 complexin 3 0.696465
EFHC2 EF-hand domain (C-terminal) containing 2 0.68639
ANTXR1 anthrax toxin receptor 1 0.666394
GNG13 guanine nucleotide binding protein (G protein), gamma 13 0.6638
KIF3A kinesin family member 3A 0.641858
RCVRN recoverin 0.639289
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.628187
CD248 CD248 molecule, endosialin 0.610355
IQSEC2 IQ motif and Sec7 domain 2 0.594332
IAPP islet amyloid polypeptide 0.589295
FUS FUS RNA binding protein 0.588875
MMP20 matrix metallopeptidase 20 0.588037
ZNF81 zinc finger protein 81 0.577164
CNOT8 CCR4-NOT transcription complex, subunit 8 0.570496
RIMBP3 RIMS binding protein 3 0.568001
GPR179 G protein-coupled receptor 179 0.568001
COPG1 coatomer protein complex, subunit gamma 1 0.561358
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.553905
AMBN ameloblastin (enamel matrix protein) 0.553491
HTRA3 HtrA serine peptidase 3 0.548535
ASMT acetylserotonin O-methyltransferase 0.547297
CPLX4 complexin 4 0.546472
WIBG within bgcn homolog (Drosophila) 0.541529
AMELX amelogenin, X-linked 0.539883
ALB albumin 0.525522
ENAM enamelin 0.516532
PROZ protein Z, vitamin K-dependent plasma glycoprotein 0.51327
PICK1 protein interacting with PRKCA 1 0.505944
EFHC1 EF-hand domain (C-terminal) containing 1 0.497826
TULP1 tubby like protein 1 0.493371
APOC2 apolipoprotein C-II 0.476429
WDR13 WD repeat domain 13 0.474822
MPO myeloperoxidase 0.47442
PHF6 PHD finger protein 6 0.472813
GDF5 growth differentiation factor 5 0.472412
PKDCC protein kinase domain containing, cytoplasmic 0.4672
GUCA1B guanylate cyclase activator 1B (retina) 0.466799
RGS11 regulator of G-protein signaling 11 0.464397
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 0.461599
IQSEC3 IQ motif and Sec7 domain 3 0.455613
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.454418
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.452825
TBKBP1 TBK1 binding protein 1 0.451631
FBLIM1 filamin binding LIM protein 1 0.448848
GCDH glutaryl-CoA dehydrogenase 0.448451
CABP7 calcium binding protein 7 0.447656
AMELY amelogenin, Y-linked 0.446862
MGAM maltase-glucoamylase 0.438937
CHGA chromogranin A 0.433012
GRM2 glutamate receptor, metabotropic 2 0.42082
RD3 retinal degeneration 3 0.420428
GRM8 glutamate receptor, metabotropic 8 0.420036
REG1B regenerating islet-derived 1 beta 0.415728
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.414946
SYN1 synapsin I 0.414164
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.41221
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.41221
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.408699
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.404804
TTYH1 tweety family member 1 0.400139
STX1A syntaxin 1A (brain) 0.399363
GRM4 glutamate receptor, metabotropic 4 0.394323
IQSEC1 IQ motif and Sec7 domain 1 0.386593
VEZF1 vascular endothelial zinc finger 1 0.385051
UNC13C unc-13 homolog C (C. elegans) 0.372749
BDNF brain-derived neurotrophic factor 0.364331
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.357847
ATM ATM serine/threonine kinase 0.356324
MAGEE1 melanoma antigen family E1 0.353282
RPS19BP1 ribosomal protein S19 binding protein 1 0.351762
CALN1 calneuron 1 0.351382
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 0.350243
EPHB3 EPH receptor B3 0.338506
GSTA3 glutathione S-transferase alpha 3 0.337373
NLGN2 neuroligin 2 0.337373
GSTA4 glutathione S-transferase alpha 4 0.335487
GSTA2 glutathione S-transferase alpha 2 0.335487
KARS lysyl-tRNA synthetase 0.334733
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.334356
GSTA1 glutathione S-transferase alpha 1 0.333225
CABP2 calcium binding protein 2 0.330213
CADM1 cell adhesion molecule 1 0.330213
GRM1 glutamate receptor, metabotropic 1 0.329837
HAND2 heart and neural crest derivatives expressed 2 0.329837
NRXN1 neurexin 1 0.328708
DNMBP dynamin binding protein 0.324951
RIMS3 regulating synaptic membrane exocytosis 3 0.32195
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.312597
AVPR2 arginine vasopressin receptor 2 0.311478
EPHA4 EPH receptor A4 0.30924
LRRC4 leucine rich repeat containing 4 0.308867
MAPT microtubule-associated protein tau 0.307004
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.304771
SCN10A sodium channel, voltage gated, type X alpha subunit 0.30254
RAB3A RAB3A, member RAS oncogene family 0.30254
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.302168
FEZF1 FEZ family zinc finger 1 0.301054
PFN2 profilin 2 0.298826
FGF14 fibroblast growth factor 14 0.296972
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.293637
WDR92 WD repeat domain 92 0.282558
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.282189
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.279612
F2 coagulation factor II (thrombin) 0.2719
FEZF2 FEZ family zinc finger 2 0.271533
TH tyrosine hydroxylase 0.267505
CALB1 calbindin 1, 28kDa 0.266042
VSX2 visual system homeobox 2 0.264215
POU4F1 POU class 4 homeobox 1 0.258745
ELANE elastase, neutrophil expressed 0.257652
NYX nyctalopin 0.257652
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.255834
SYNJ1 synaptojanin 1 0.252564
SRR serine racemase 0.252202
NTNG2 netrin G2 0.252202
GRM6 glutamate receptor, metabotropic 6 0.249664
DNAH8 dynein, axonemal, heavy chain 8 0.248216
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2 0.244601
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.241356
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.240996
RHO rhodopsin 0.240996
OPLAH 5-oxoprolinase (ATP-hydrolysing) 0.240276
FAM134B family with sequence similarity 134, member B 0.238478
ADCY8 adenylate cyclase 8 (brain) 0.238478
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.238478
TUFT1 tuftelin 1 0.237042
GGT1 gamma-glutamyltransferase 1 0.235966
GIN1 gypsy retrotransposon integrase 1 0.233459
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.232386
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.230958
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.22385
PFN4 profilin family, member 4 0.223497
ENO2 enolase 2 (gamma, neuronal) 0.217511
FBL fibrillarin 0.21716
HBE1 hemoglobin, epsilon 1 0.215412
XYLT1 xylosyltransferase I 0.215063
CHURC1 churchill domain containing 1 0.215063
CS citrate synthase 0.211587
UBE4B ubiquitination factor E4B 0.199659
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.199325
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.199325
LIAS lipoic acid synthetase 0.199325
PFN1 profilin 1 0.195681
KIRREL2 kin of IRRE like 2 (Drosophila) 0.195025
LIN7C lin-7 homolog C (C. elegans) 0.194045
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.193719
NGEF neuronal guanine nucleotide exchange factor 0.192423
RGN regucalcin 0.188274
KRT36 keratin 36, type I 0.186397
SPAG9 sperm associated antigen 9 0.186397
PAH phenylalanine hydroxylase 0.183025
SAG S-antigen; retina and pineal gland (arrestin) 0.179167
SYT2 synaptotagmin II 0.178299
RPH3A rabphilin 3A 0.175188
CNR1 cannabinoid receptor 1 (brain) 0.174635
S1PR4 sphingosine-1-phosphate receptor 4 0.170629
CLDN14 claudin 14 0.169604
EPHB2 EPH receptor B2 0.168349
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.166167
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.166167
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.165932
CRP C-reactive protein, pentraxin-related 0.165932
SST somatostatin 0.165697
GAST gastrin 0.164089
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.160254
SFTPA2 surfactant protein A2 0.160053
GSTM2 glutathione S-transferase mu 2 (muscle) 0.156342