presynaptic active zone Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix. (Gene Ontology, GO_0048786)
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25 proteins localized to the presynaptic active zone cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.237908
BSN bassoon presynaptic cytomatrix protein 0.237908
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.237908
GRM7 glutamate receptor, metabotropic 7 0.237908
UNC13B unc-13 homolog B (C. elegans) 0.237908
UNC13C unc-13 homolog C (C. elegans) 0.237908
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.237908
GPER1 G protein-coupled estrogen receptor 1 0.237908
UNC13A unc-13 homolog A (C. elegans) 0.237908
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.237908
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.237908
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.237908
RIMS3 regulating synaptic membrane exocytosis 3 0.237908
RIMS1 regulating synaptic membrane exocytosis 1 0.237908
RIMS4 regulating synaptic membrane exocytosis 4 0.237908
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.237908
FZD3 frizzled class receptor 3 0.098109
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.03318
GRM4 glutamate receptor, metabotropic 4 0.03318
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.03318
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.03318
SV2A synaptic vesicle glycoprotein 2A 0.03318
ADORA1 adenosine A1 receptor 0.03318
SYP synaptophysin 0.03318
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.03318