premature ovarian failure Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. (Human Disease Ontology, DOID_5426)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0008209
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Genes

101 genes associated with the premature ovarian failure phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 1.07748
MCC mutated in colorectal cancers 0.675718
PLXDC2 plexin domain containing 2 0.628991
DCP2 decapping mRNA 2 0.615351
SCARA5 scavenger receptor class A, member 5 0.614021
NEK11 NIMA-related kinase 11 0.58318
PUM2 pumilio RNA-binding family member 2 0.573361
PERP PERP, TP53 apoptosis effector 0.563675
KIAA1217 KIAA1217 0.541144
ZNF831 zinc finger protein 831 0.532619
CSMD1 CUB and Sushi multiple domains 1 0.531908
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.53086
FNDC3B fibronectin type III domain containing 3B 0.524164
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.522995
EPHA4 EPH receptor A4 0.521853
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.521572
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.515749
VCL vinculin 0.51476
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.507122
NPAP1 nuclear pore associated protein 1 0.502058
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.502058
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.501261
CADM2 cell adhesion molecule 2 0.50044
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.50044
SACS sacsin molecular chaperone 0.496025
HEG1 heart development protein with EGF-like domains 1 0.493763
NUP98 nucleoporin 98kDa 0.49303
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.492848
MAPK14 mitogen-activated protein kinase 14 0.484604
WDR26 WD repeat domain 26 0.484264
DOCK1 dedicator of cytokinesis 1 0.482921
LRP1B low density lipoprotein receptor-related protein 1B 0.481126
NIN ninein (GSK3B interacting protein) 0.4797
AQP9 aquaporin 9 0.479077
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.478768
BAHCC1 BAH domain and coiled-coil containing 1 0.478614
HUNK hormonally up-regulated Neu-associated kinase 0.477701
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.471968
PRKG1 protein kinase, cGMP-dependent, type I 0.470384
SPAG17 sperm associated antigen 17 0.46923
PVT1 Pvt1 oncogene (non-protein coding) 0.468662
PTCRA pre T-cell antigen receptor alpha 0.468239
PDGFD platelet derived growth factor D 0.467264
CACHD1 cache domain containing 1 0.46404
CSMD2 CUB and Sushi multiple domains 2 0.46404
GRID2 glutamate receptor, ionotropic, delta 2 0.46211
PARD3B par-3 family cell polarity regulator beta 0.461858
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.461606
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.460859
MR1 major histocompatibility complex, class I-related 0.460612
SASH1 SAM and SH3 domain containing 1 0.458078
IGF2R insulin-like growth factor 2 receptor 0.457491
NCKAP5 NCK-associated protein 5 0.456563
FRYL FRY-like 0.455651
NELL2 NEL-like 2 (chicken) 0.45519
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.454387
SLC44A3 solute carrier family 44, member 3 0.45382
PAX8 paired box 8 0.453483
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.452813
HELQ helicase, POLQ-like 0.451497
BTBD9 BTB (POZ) domain containing 9 0.450743
KIAA0226L KIAA0226-like 0.450636
ATP8B4 ATPase, class I, type 8B, member 4 0.450316
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.449471
LOXHD1 lipoxygenase homology domains 1 0.449158
TUBA8 tubulin, alpha 8 0.447311
DOCK2 dedicator of cytokinesis 2 0.446609
NLGN1 neuroligin 1 0.44631
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.445915
ZDHHC14 zinc finger, DHHC-type containing 14 0.444937
CYYR1 cysteine/tyrosine-rich 1 0.443785
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.443785
DROSHA drosha, ribonuclease type III 0.440552
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.439578
TPRG1 tumor protein p63 regulated 1 0.438739
ESPNL espin-like 0.438513
INTS9 integrator complex subunit 9 0.437029
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.436087
WWOX WW domain containing oxidoreductase 0.434812
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.434463
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.434394
MYOM2 myomesin 2 0.432488
BDNF-AS BDNF antisense RNA 0.431759
DNHD1 dynein heavy chain domain 1 0.43143
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 0.429318
PTPRT protein tyrosine phosphatase, receptor type, T 0.429318
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.428633
MGC27382 uncharacterized MGC27382 0.428386
MST1 macrophage stimulating 1 0.427291
THSD4 thrombospondin, type I, domain containing 4 0.427111
PKD1L1 polycystic kidney disease 1 like 1 0.426693
FRMD4A FERM domain containing 4A 0.426575
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.426575
GPR158 G protein-coupled receptor 158 0.425625
DISC1 disrupted in schizophrenia 1 0.425625
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.425507
MYO5C myosin VC 0.42535
C5ORF22 chromosome 5 open reading frame 22 0.42535
SCFD2 sec1 family domain containing 2 0.425155
TBX15 T-box 15 0.425117
TMEM164 transmembrane protein 164 0.424884