postsynaptic density Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell. (Gene Ontology, GO_0014069)
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327 proteins co-occuring with the postsynaptic density cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.3577
SHANK3 SH3 and multiple ankyrin repeat domains 3 2.14423
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.14132
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.09255
HOMER1 homer scaffolding protein 1 2.0098
DLG3 discs, large homolog 3 (Drosophila) 1.96004
DLG1 discs, large homolog 1 (Drosophila) 1.91326
PSD pleckstrin and Sec7 domain containing 1.88072
TJP1 tight junction protein 1 1.85388
SHANK1 SH3 and multiple ankyrin repeat domains 1 1.76626
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.75467
GUK1 guanylate kinase 1 1.67204
DLG4 discs, large homolog 4 (Drosophila) 1.65453
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 1.51694
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.47344
LRRC7 leucine rich repeat containing 7 1.37796
BDNF brain-derived neurotrophic factor 1.33522
GPHN gephyrin 1.32708
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.27877
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.27824
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.27824
SYP synaptophysin 1.27239
GRIP1 glutamate receptor interacting protein 1 1.23557
PICK1 protein interacting with PRKCA 1 1.19777
GRM5 glutamate receptor, metabotropic 5 1.19777
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.1952
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 1.19108
HOMER2 homer scaffolding protein 2 1.17209
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.16389
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 1.13114
PPP1R9B protein phosphatase 1, regulatory subunit 9B 1.11327
NLGN1 neuroligin 1 1.1046
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.0812
GRM1 glutamate receptor, metabotropic 1 1.07968
PISD phosphatidylserine decarboxylase 1.04984
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.04934
CABP1 calcium binding protein 1 1.02929
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.02281
CRIPT cysteine-rich PDZ-binding protein 1.01585
BAIAP2 BAI1-associated protein 2 0.990247
RBM10 RNA binding motif protein 10 0.949236
RAP1GAP RAP1 GTPase activating protein 0.944956
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.944007
DBN1 drebrin 1 0.931716
ARC activity-regulated cytoskeleton-associated protein 0.928422
SYN1 synapsin I 0.927013
BSN bassoon presynaptic cytomatrix protein 0.921386
FYN FYN proto-oncogene, Src family tyrosine kinase 0.906926
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.904602
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.878712
NLGN2 neuroligin 2 0.863068
CTNND2 catenin (cadherin-associated protein), delta 2 0.86169
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.843778
IQSEC2 IQ motif and Sec7 domain 2 0.832761
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.804772
MPDZ multiple PDZ domain protein 0.801562
GRIK1 glutamate receptor, ionotropic, kainate 1 0.79927
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.795604
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.749546
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.741416
SDCBP2 syndecan binding protein (syntenin) 2 0.736464
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.731524
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.727494
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.723919
BEGAIN brain-enriched guanylate kinase-associated 0.717236
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.71457
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.713682
SHARPIN SHANK-associated RH domain interactor 0.713238
DNM3 dynamin 3 0.710136
PRR7 proline rich 7 (synaptic) 0.708808
PDZK1 PDZ domain containing 1 0.706156
PDLIM5 PDZ and LIM domain 5 0.70439
RGS7BP regulator of G-protein signaling 7 binding protein 0.700863
MAP2 microtubule-associated protein 2 0.69427
ERBB4 erb-b2 receptor tyrosine kinase 4 0.689013
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.683771
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.677238
CREB1 cAMP responsive element binding protein 1 0.656464
PVALB parvalbumin 0.654311
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.643572
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.636295
ACTN2 actinin, alpha 2 0.628187
HOMER3 homer scaffolding protein 3 0.617133
MAP1A microtubule-associated protein 1A 0.610355
RELN reelin 0.609509
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.608241
CTTN cortactin 0.603174
BAIAP2L1 BAI1-associated protein 2-like 1 0.601066
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.594332
FMR1 fragile X mental retardation 1 0.582176
LIN7A lin-7 homolog A (C. elegans) 0.573411
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.570496
CALB1 calbindin 1, 28kDa 0.569248
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.567585
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.567169
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.565508
ISL1 ISL LIM homeobox 1 0.564677
ANK1 ankyrin 1, erythrocytic 0.564262
CTBP2 C-terminal binding protein 2 0.558457
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.558042
NEXN nexilin (F actin binding protein) 0.555145
DISC1 disrupted in schizophrenia 1 0.551425
GDA guanine deaminase 0.550186
INA internexin neuronal intermediate filament protein, alpha 0.54771
TARP TCR gamma alternate reading frame protein 0.545236
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.539472
SCRIB scribbled planar cell polarity protein 0.530028
CDK5 cyclin-dependent kinase 5 0.528388
RNASE13 ribonuclease, RNase A family, 13 (non-active) 0.522659
SYNGAP1 synaptic Ras GTPase activating protein 1 0.520206
SDCBP syndecan binding protein (syntenin) 0.516124
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.5149
GJD2 gap junction protein, delta 2, 36kDa 0.512862
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.507163
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.506757
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.505537
ZDHHC8 zinc finger, DHHC-type containing 8 0.500664
PRICKLE2 prickle homolog 2 (Drosophila) 0.500258
PTCHD1 patched domain containing 1 0.498231
RAP1GAP2 RAP1 GTPase activating protein 2 0.492561
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2 0.492157
EPHB2 EPH receptor B2 0.490539
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.489327
LRRC4 leucine rich repeat containing 4 0.487711
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.4865
FBXO33 F-box protein 33 0.486096
LZTS2 leucine zipper, putative tumor suppressor 2 0.483676
ADGRL3 adhesion G protein-coupled receptor L3 0.483676
GAP43 growth associated protein 43 0.482467
SEZ6 seizure related 6 homolog (mouse) 0.48005
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.473215
ARF6 ADP-ribosylation factor 6 0.4676
ZDHHC2 zinc finger, DHHC-type containing 2 0.4672
PLEK pleckstrin 0.464798
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.462798
ADGRL2 adhesion G protein-coupled receptor L2 0.461199
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.4608
NCR3 natural cytotoxicity triggering receptor 3 0.459602
DMD dystrophin 0.458803
EPHB3 EPH receptor B3 0.458006
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.446862
ABI2 abl-interactor 2 0.446069
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.446069
GOPC golgi-associated PDZ and coiled-coil motif containing 0.438542
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.434985
SNTA1 syntrophin, alpha 1 0.433801
BTBD3 BTB (POZ) domain containing 3 0.426711
CBLN1 cerebellin 1 precursor 0.425924
GRIK2 glutamate receptor, ionotropic, kainate 2 0.425924
KALRN kalirin, RhoGEF kinase 0.422782
NRXN1 neurexin 1 0.422389
TH tyrosine hydroxylase 0.421997
ZMYND19 zinc finger, MYND-type containing 19 0.41886
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.417685
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.417294
GRM3 glutamate receptor, metabotropic 3 0.41612
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.41612
PSD2 pleckstrin and Sec7 domain containing 2 0.415337
PDZD3 PDZ domain containing 3 0.41221
VEZT vezatin, adherens junctions transmembrane protein 0.411039
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.40714
NLGN3 neuroligin 3 0.40247
AKAP5 A kinase (PRKA) anchor protein 5 0.400916
NSF N-ethylmaleimide-sensitive factor 0.398975
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.39626
MECP2 methyl CpG binding protein 2 0.391228
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive 0.389296
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.377354
SERF1A small EDRK-rich factor 1A (telomeric) 0.375434
SERF1B small EDRK-rich factor 1B (centromeric) 0.375434
APLP1 amyloid beta (A4) precursor-like protein 1 0.373516
ARHGAP32 Rho GTPase activating protein 32 0.371982
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.371599
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.370833
ASIC3 acid sensing (proton gated) ion channel 3 0.37045
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.370067
IQSEC3 IQ motif and Sec7 domain 3 0.369684
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.369684
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.367388
TBKBP1 TBK1 binding protein 1 0.365477
KLHL17 kelch-like family member 17 0.364331
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 0.363567
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.363185
KARS lysyl-tRNA synthetase 0.358228
TRIM11 tripartite motif containing 11 0.351382
MORN4 MORN repeat containing 4 0.350622
GRID2 glutamate receptor, ionotropic, delta 2 0.349863
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.346829
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.337373
SHISA9 shisa family member 9 0.336996
GRM2 glutamate receptor, metabotropic 2 0.33511
EZR ezrin 0.333979
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.333225
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.332472
PTPRD protein tyrosine phosphatase, receptor type, D 0.330966
SYNPO synaptopodin 0.328708
IL16 interleukin 16 0.326453
EPHA4 EPH receptor A4 0.324951
NRG1 neuregulin 1 0.324951
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.324951
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.323825
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.32345
DNM2 dynamin 2 0.3227
CADM1 cell adhesion molecule 1 0.32195
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.321201
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 0.321201
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.318953
NGF nerve growth factor (beta polypeptide) 0.318953
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.318579
ADAM22 ADAM metallopeptidase domain 22 0.315212
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.313344
PTK2B protein tyrosine kinase 2 beta 0.312224
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.311851
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.311105
DTNB dystrobrevin, beta 0.30924
NRCAM neuronal cell adhesion molecule 0.308122
KIF26B kinesin family member 26B 0.305888
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.302168
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 0.301797
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.299197
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.295489
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.293267
DRD2 dopamine receptor D2 0.292897
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.292527
CDC42 cell division cycle 42 0.292527
SRCIN1 SRC kinase signaling inhibitor 1 0.286614
PBK PDZ binding kinase 0.284401
CCDC88C coiled-coil domain containing 88C 0.282189
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.281453
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.281085
DAGLA diacylglycerol lipase, alpha 0.279245
MYO5A myosin VA (heavy chain 12, myoxin) 0.276304
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.275202
SLC16A4 solute carrier family 16, member 4 0.274468
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.273
CRMP1 collapsin response mediator protein 1 0.268603
STRN striatin, calmodulin binding protein 0.268237
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.260202
HTRA2 HtrA serine peptidase 2 0.258381
TRIM3 tripartite motif containing 3 0.256925
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.256197
ADGRL1 adhesion G protein-coupled receptor L1 0.25547
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.249302
NTNG1 netrin G1 0.24894
PHC3 polyhomeotic homolog 3 (Drosophila) 0.24713
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.245685
CALB2 calbindin 2 0.243879
LGI1 leucine-rich, glioma inactivated 1 0.243879
GRIP2 glutamate receptor interacting protein 2 0.242797
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.242076
EPB41 erythrocyte membrane protein band 4.1 0.238478
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.235966
RGS9 regulator of G-protein signaling 9 0.235249
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.234891
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.234174
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.228464
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.228464
NLGN4X neuroligin 4, X-linked 0.227752
DGKB diacylglycerol kinase, beta 90kDa 0.225976
SAMD4A sterile alpha motif domain containing 4A 0.22385
PCDH9 protocadherin 9 0.221378
NOS1 nitric oxide synthase 1 (neuronal) 0.221025
DTNBP1 dystrobrevin binding protein 1 0.220321
DRP2 dystrophin related protein 2 0.220321
PDLIM2 PDZ and LIM domain 2 (mystique) 0.219969
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.21716
INADL InaD-like (Drosophila) 0.21646
KIF1B kinesin family member 1B 0.21646
CPLX2 complexin 2 0.215761
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.213322
RIMS3 regulating synaptic membrane exocytosis 3 0.212974
APC adenomatous polyposis coli 0.21228
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 0.211587
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.21124
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.210549
PLK2 polo-like kinase 2 0.209858
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.209858
GSK3B glycogen synthase kinase 3 beta 0.207108
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.206423
NGFR nerve growth factor receptor 0.206423
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.206423
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.206423
FXYD6 FXYD domain containing ion transport regulator 6 0.205059
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.203361
MYH15 myosin, heavy chain 15 0.199325
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.197993
UBE3A ubiquitin protein ligase E3A 0.195025
CYLD cylindromatosis (turban tumor syndrome) 0.194698
NOSIP nitric oxide synthase interacting protein 0.193394
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.191456
CPLX1 complexin 1 0.189857
VASP vasodilator-stimulated phosphoprotein 0.186708
SYT1 synaptotagmin I 0.185777
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.182122
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.182122
MAPT microtubule-associated protein tau 0.181227
AMPH amphiphysin 0.180045
LRRC4C leucine rich repeat containing 4C 0.179459
VANGL2 VANGL planar cell polarity protein 2 0.178299
HTT huntingtin 0.178011
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.177724
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.174911
DYNLL2 dynein, light chain, LC8-type 2 0.174911
UTRN utrophin 0.172201
TLL1 tolloid-like 1 0.170114
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.169604
INSR insulin receptor 0.169604
SNAP25 synaptosomal-associated protein, 25kDa 0.168101
RTN4 reticulon 4 0.166167
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.165463
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.165231
CNR1 cannabinoid receptor 1 (brain) 0.165231
APP amyloid beta (A4) precursor protein 0.164542
AGRN agrin 0.16298
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.162763
PDLIM4 PDZ and LIM domain 4 0.162117
GIPC1 GIPC PDZ domain containing family, member 1 0.161484
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.161484
NDFIP1 Nedd4 family interacting protein 1 0.160863
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.160053
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.159856
WDR92 WD repeat domain 92 0.159462
NTNG2 netrin G2 0.158692
TIAM2 T-cell lymphoma invasion and metastasis 2 0.158129
NTF4 neurotrophin 4 0.157218
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.157218
NRP1 neuropilin 1 0.156342