postsynaptic density Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell. (Gene Ontology, GO_0014069)
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87 proteins localized to the postsynaptic density cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NLGN4X neuroligin 4, X-linked 0.663342
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.663342
DTNBP1 dystrobrevin binding protein 1 0.663342
MPDZ multiple PDZ domain protein 0.663342
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.663342
NCS1 neuronal calcium sensor 1 0.663342
DNM2 dynamin 2 0.663342
HOMER2 homer scaffolding protein 2 0.663342
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.663342
CABP1 calcium binding protein 1 0.663342
GPER1 G protein-coupled estrogen receptor 1 0.237908
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.237908
DNM3 dynamin 3 0.237908
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.237908
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.237908
DLG4 discs, large homolog 4 (Drosophila) 0.237908
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.237908
SYNDIG1 synapse differentiation inducing 1 0.237908
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.237908
STRN striatin, calmodulin binding protein 0.237908
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.237908
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.237908
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 0.237908
PDLIM5 PDZ and LIM domain 5 0.237908
RGS14 regulator of G-protein signaling 14 0.237908
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.237908
SRCIN1 SRC kinase signaling inhibitor 1 0.237908
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.237908
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.237908
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.237908
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.237908
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.237908
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.237908
CDK5 cyclin-dependent kinase 5 0.237908
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.237908
AXIN1 axin 1 0.098109
GRM1 glutamate receptor, metabotropic 1 0.098109
GRM5 glutamate receptor, metabotropic 5 0.098109
LRP4 low density lipoprotein receptor-related protein 4 0.098109
PTK2B protein tyrosine kinase 2 beta 0.098109
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.098109
AXIN2 axin 2 0.098109
CRIPT cysteine-rich PDZ-binding protein 0.098109
ADD1 adducin 1 (alpha) 0.03318
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.03318
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.03318
FYN FYN proto-oncogene, Src family tyrosine kinase 0.03318
IFNGR1 interferon gamma receptor 1 0.03318
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.03318
HOMER3 homer scaffolding protein 3 0.03318
PLCB4 phospholipase C, beta 4 0.03318
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.03318
ITGA8 integrin, alpha 8 0.03318
LZTS1 leucine zipper, putative tumor suppressor 1 0.03318
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.03318
MYD88 myeloid differentiation primary response 88 0.03318
EPS8 epidermal growth factor receptor pathway substrate 8 0.03318
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.03318
SHARPIN SHANK-associated RH domain interactor 0.03318
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 0.03318
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.03318
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.03318
FBXO45 F-box protein 45 0.03318
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.03318
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.03318
EPHA4 EPH receptor A4 0.03318
LYN LYN proto-oncogene, Src family tyrosine kinase 0.03318
SOS1 son of sevenless homolog 1 (Drosophila) 0.03318
KLHL17 kelch-like family member 17 0.03318
ADAM10 ADAM metallopeptidase domain 10 0.03318
DRD2 dopamine receptor D2 0.03318
ADORA1 adenosine A1 receptor 0.03318
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.03318
DBNL drebrin-like 0.03318
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.03318
GRM3 glutamate receptor, metabotropic 3 0.03318
CHRM1 cholinergic receptor, muscarinic 1 0.03318
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.03318
GRIK5 glutamate receptor, ionotropic, kainate 5 0.03318
GRIK2 glutamate receptor, ionotropic, kainate 2 0.03318
ARRB1 arrestin, beta 1 0.03318
ARRB2 arrestin, beta 2 0.03318
DLG1 discs, large homolog 1 (Drosophila) 0.03318
ACTB actin, beta 0.03318
RAB8A RAB8A, member RAS oncogene family 0.03318
RAB8B RAB8B, member RAS oncogene family 0.03318
PTCH1 patched 1 0.03318