positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction. (Gene Ontology, GO_0086094)
External Link http://amigo.geneontology.org/amigo/term/GO:0086094
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Genes

1 genes participating in the positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
RYR2 ryanodine receptor 2 (cardiac)