positive regulation of mapk cascade Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. (Gene Ontology, GO_0043410)
External Link http://amigo.geneontology.org/amigo/term/GO:0043410
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Genes

407 genes participating in the positive regulation of mapk cascade biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADORA1 adenosine A1 receptor
ADORA2B adenosine A2b receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AJUBA ajuba LIM protein
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOX15 arachidonate 15-lipoxygenase
ANGPT1 angiopoietin 1
ANKRD6 ankyrin repeat domain 6
ARHGAP8 Rho GTPase activating protein 8
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
AVPI1 arginine vasopressin-induced 1
AXIN1 axin 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BIRC7 baculoviral IAP repeat containing 7
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPER BMP binding endothelial regulator
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1QTNF2 C1q and tumor necrosis factor related protein 2
C5 complement component 5
C5AR1 complement component 5a receptor 1
C5AR2 complement component 5a receptor 2
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CARD9 caspase recruitment domain family, member 9
CARTPT CART prepropeptide
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCR1 chemokine (C-C motif) receptor 1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD27 CD27 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK10 cyclin-dependent kinase 10
CDON cell adhesion associated, oncogene regulated
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1R colony stimulating factor 1 receptor
CSK c-src tyrosine kinase
CSPG4 chondroitin sulfate proteoglycan 4
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR4 chemokine (C-X-C motif) receptor 4
CYSLTR2 cysteinyl leukotriene receptor 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DAXX death-domain associated protein
DBNL drebrin-like
DCC DCC netrin 1 receptor
DIRAS1 DIRAS family, GTP-binding RAS-like 1
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DIXDC1 DIX domain containing 1
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP15 dual specificity phosphatase 15
DUSP19 dual specificity phosphatase 19
DUSP22 dual specificity phosphatase 22
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EDA2R ectodysplasin A2 receptor
EDN1 endothelin 1
EDN3 endothelin 3
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELANE elastase, neutrophil expressed
EPGN epithelial mitogen
EPHA4 EPH receptor A4
EPHA8 EPH receptor A8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC6 excision repair cross-complementation group 6
EREG epiregulin
ERP29 endoplasmic reticulum protein 29
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM58A family with sequence similarity 58, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FFAR4 free fatty acid receptor 4
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGF4 fibroblast growth factor 4
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FPR1 formyl peptide receptor 1
FRS2 fibroblast growth factor receptor substrate 2
FZD10 frizzled class receptor 10
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
GAB1 GRB2-associated binding protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GAREM GRB2 associated, regulator of MAPK1
GAS6 growth arrest-specific 6
GCG glucagon
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GLIPR2 GLI pathogenesis-related 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPER1 G protein-coupled estrogen receptor 1
GPR183 G protein-coupled receptor 183
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR37L1 G protein-coupled receptor 37 like 1
GPR55 G protein-coupled receptor 55
GRM1 glutamate receptor, metabotropic 1
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
HACD3 3-hydroxyacyl-CoA dehydratase 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK2 homeodomain interacting protein kinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL26 interleukin 26
IL6 interleukin 6
ILK integrin-linked kinase
INS insulin
INSR insulin receptor
IQGAP3 IQ motif containing GTPase activating protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
ITGA1 integrin, alpha 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KIAA1804 mixed lineage kinase 4
KIDINS220 kinase D-interacting substrate, 220kDa
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LEP leptin
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LRRK2 leucine-rich repeat kinase 2
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MADD MAP-kinase activating death domain
MAGED1 melanoma antigen family D1
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K15 mitogen-activated protein kinase kinase kinase 15
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDFI MyoD family inhibitor
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MID1 midline 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINK1 misshapen-like kinase 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MST1R macrophage stimulating 1 receptor
MT3 metallothionein 3
MUC20 mucin 20, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYDGF myeloid-derived growth factor
NDRG4 NDRG family member 4
NEK1 NIMA-related kinase 1
NEK10 NIMA-related kinase 10
NENF neudesin neurotrophic factor
NGF nerve growth factor (beta polypeptide)
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NODAL nodal growth differentiation factor
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NPNT nephronectin
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRK Nik related kinase
NRP1 neuropilin 1
NTF3 neurotrophin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPRM1 opioid receptor, mu 1
OSM oncostatin M
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDCD10 programmed cell death 10
PDE5A phosphodiesterase 5A, cGMP-specific
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PKN1 protein kinase N1
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G5 phospholipase A2, group V
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PRKCDBP protein kinase C, delta binding protein
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PROK1 prokineticin 1
PROK2 prokineticin 2
PSEN1 presenilin 1
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
PYCARD PYD and CARD domain containing
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARA retinoic acid receptor, alpha
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RPS27A ribosomal protein S27a
RYK receptor-like tyrosine kinase
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S1PR2 sphingosine-1-phosphate receptor 2
SAA1 serum amyloid A1
SASH1 SAM and SH3 domain containing 1
SBK2 SH3 domain binding kinase family, member 2
SCIMP SLP adaptor and CSK interacting membrane protein
SDCBP syndecan binding protein (syntenin)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SOD1 superoxide dismutase 1, soluble
SORBS3 sorbin and SH3 domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPAG9 sperm associated antigen 9
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSTR4 somatostatin receptor 4
STK25 serine/threonine kinase 25
STK3 serine/threonine kinase 3
SYK spleen tyrosine kinase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAOK1 TAO kinase 1
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TBX1 T-box 1
TDGF1 teratocarcinoma-derived growth factor 1
TEK TEK tyrosine kinase, endothelial
TENM1 teneurin transmembrane protein 1
TFF2 trefoil factor 2
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
THPO thrombopoietin
TIMP2 TIMP metallopeptidase inhibitor 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIK TRAF2 and NCK interacting kinase
TP73 tumor protein p73
TPD52L1 tumor protein D52-like 1
TRAF2 TNF receptor-associated factor 2
TRAF4 TNF receptor-associated factor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRIM5 tripartite motif containing 5
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UNC5CL unc-5 homolog C (C. elegans)-like
VANGL2 VANGL planar cell polarity protein 2
VEGFA vascular endothelial growth factor A
WNT16 wingless-type MMTV integration site family, member 16
WNT5A wingless-type MMTV integration site family, member 5A
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WWC1 WW and C2 domain containing 1
XDH xanthine dehydrogenase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZEB2 zinc finger E-box binding homeobox 2
ZNF622 zinc finger protein 622