pituitary gland disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An endocrine system disease that is located_in the pituitary gland. (Human Disease Ontology, DOID_53)
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Genes

242 genes co-occuring with the disease pituitary gland disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 2.6244
AVP arginine vasopressin 2.56721
HESX1 HESX homeobox 1 2.26692
IGF1 insulin-like growth factor 1 (somatomedin C) 2.22873
PROP1 PROP paired-like homeobox 1 2.18978
GHRH growth hormone releasing hormone 2.11925
TRH thyrotropin-releasing hormone 2.07259
LHX4 LIM homeobox 4 2.04416
PRL prolactin 2.00562
LHX3 LIM homeobox 3 1.95582
POU1F1 POU class 1 homeobox 1 1.95018
SOX3 SRY (sex determining region Y)-box 3 1.90987
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.7939
INS insulin 1.72183
CRH corticotropin releasing hormone 1.70952
SST somatostatin 1.39564
IGFBP3 insulin-like growth factor binding protein 3 1.33894
AVPR2 arginine vasopressin receptor 2 1.31755
AQP2 aquaporin 2 (collecting duct) 1.30794
GCG glucagon 1.20872
GHRHR growth hormone releasing hormone receptor 1.14687
OTX2 orthodenticle homeobox 2 1.09923
GH1 growth hormone 1 1.07362
SOX2 SRY (sex determining region Y)-box 2 1.02819
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 1.01807
GLI2 GLI family zinc finger 2 0.977165
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.975482
TBX19 T-box 19 0.973801
NPPA natriuretic peptide A 0.854859
SCRT1 scratch family zinc finger 1 0.828639
MEN1 multiple endocrine neoplasia I 0.782707
RNPC3 RNA-binding region (RNP1, RRM) containing 3 0.771252
GHRL ghrelin/obestatin prepropeptide 0.75412
IGFBP1 insulin-like growth factor binding protein 1 0.728952
MNX1 motor neuron and pancreas homeobox 1 0.726929
REN renin 0.71078
PITX2 paired-like homeodomain 2 0.707157
PITX1 paired-like homeodomain 1 0.693098
SHBG sex hormone-binding globulin 0.617877
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.613965
FRS3 fibroblast growth factor receptor substrate 3 0.58939
GHR growth hormone receptor 0.585108
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.570718
ILVBL ilvB (bacterial acetolactate synthase)-like 0.559839
SIX3 SIX homeobox 3 0.55712
TSHB thyroid stimulating hormone, beta 0.555956
SHH sonic hedgehog 0.550134
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.548195
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.545093
LEP leptin 0.539667
CRHBP corticotropin releasing hormone binding protein 0.508424
ARPC5L actin related protein 2/3 complex, subunit 5-like 0.488549
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.486266
AIP aryl hydrocarbon receptor interacting protein 0.472604
TG thyroglobulin 0.469954
SIX6 SIX homeobox 6 0.458241
BGLAP bone gamma-carboxyglutamate (gla) protein 0.452208
GFRA2 GDNF family receptor alpha 2 0.449947
TLE2 transducin-like enhancer of split 2 0.430017
ATP11C ATPase, class VI, type 11C 0.427015
CSH2 chorionic somatomammotropin hormone 2 0.406425
NPAT nuclear protein, ataxia-telangiectasia locus 0.406051
IGF2 insulin-like growth factor 2 0.391885
AQP7 aquaporin 7 0.387794
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.359657
AQP4 aquaporin 4 0.346409
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.338707
PROKR2 prokineticin receptor 2 0.3292
OXT oxytocin/neurophysin I prepropeptide 0.30848
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.308118
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.307757
H1FX H1 histone family, member X 0.306672
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.302698
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.301976
HN1L hematological and neurological expressed 1-like 0.297651
BMP4 bone morphogenetic protein 4 0.296571
AQP6 aquaporin 6, kidney specific 0.282225
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.280082
FOXD3 forkhead box D3 0.272953
CFC1 cripto, FRL-1, cryptic family 1 0.260538
KLK8 kallikrein-related peptidase 8 0.260184
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.258417
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.248905
ALB albumin 0.248905
IVL involucrin 0.246799
ADGRV1 adhesion G protein-coupled receptor V1 0.246448
PROK2 prokineticin 2 0.235964
AR androgen receptor 0.23353
PIDD1 p53-induced death domain protein 1 0.227297
PTH parathyroid hormone 0.218715
CD68 CD68 molecule 0.209583
THAP3 THAP domain containing, apoptosis associated protein 3 0.207245
SSTR5 somatostatin receptor 5 0.204263
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 0.200331
HFE hemochromatosis 0.200006
CALCA calcitonin-related polypeptide alpha 0.194865
NODAL nodal growth differentiation factor 0.193285
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.192971
GNAS GNAS complex locus 0.191097
CHD7 chromodomain helicase DNA binding protein 7 0.190786
GLB1 galactosidase, beta 1 0.188632
SYP synaptophysin 0.187113
CHGA chromogranin A 0.185612
TF transferrin 0.185612
ZIC3 Zic family member 3 0.180937
RHOD ras homolog family member D 0.180367
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.177029
SIM1 single-minded family bHLH transcription factor 1 0.175679
CRP C-reactive protein, pentraxin-related 0.172544
IRF6 interferon regulatory factor 6 0.172291
TRHR thyrotropin-releasing hormone receptor 0.171036
HADH hydroxyacyl-CoA dehydrogenase 0.168854
CNTN5 contactin 5 0.160574
ADM2 adrenomedullin 2 0.158266
SIX4 SIX homeobox 4 0.158097
GSAP gamma-secretase activating protein 0.142628
SETD2 SET domain containing 2 0.140039
SETD1A SET domain containing 1A 0.139345
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.135766
IVD isovaleryl-CoA dehydrogenase 0.135736
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.135688
MAP9 microtubule-associated protein 9 0.135563
MC3R melanocortin 3 receptor 0.135412
SSTR2 somatostatin receptor 2 0.13421
SCG5 secretogranin V 0.133166
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.132826
GHDC GH3 domain containing 0.131761
CD59 CD59 molecule, complement regulatory protein 0.129789
PPY pancreatic polypeptide 0.128636
SSTR1 somatostatin receptor 1 0.127491
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.126425
RPL22 ribosomal protein L22 0.125704
SNED1 sushi, nidogen and EGF-like domains 1 0.125561
VIP vasoactive intestinal peptide 0.124246
GAST gastrin 0.123261
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.122837
LIM2 lens intrinsic membrane protein 2, 19kDa 0.120622
LIN7A lin-7 homolog A (C. elegans) 0.120104
SSTR3 somatostatin receptor 3 0.119893
GH2 growth hormone 2 0.118886
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.117514
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.116433
ACOT13 acyl-CoA thioesterase 13 0.115683
GAL galanin/GMAP prepropeptide 0.115356
CD3D CD3d molecule, delta (CD3-TCR complex) 0.11429
SALL1 spalt-like transcription factor 1 0.113851
IGFBP5 insulin-like growth factor binding protein 5 0.113341
SSTR4 somatostatin receptor 4 0.113243
GHSR growth hormone secretagogue receptor 0.111141
AQP3 aquaporin 3 (Gill blood group) 0.109495
ESRP1 epithelial splicing regulatory protein 1 0.108848
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.108757
HES5 hes family bHLH transcription factor 5 0.106451
ADCY3 adenylate cyclase 3 0.106235
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.106091
KL klotho 0.105629
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.104413
AQP8 aquaporin 8 0.10411
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.10363
CORIN corin, serine peptidase 0.103164
DRD2 dopamine receptor D2 0.102698
PNMA2 paraneoplastic Ma antigen 2 0.102595
ADCY5 adenylate cyclase 5 0.102306
EP300 E1A binding protein p300 0.102173
SALL4 spalt-like transcription factor 4 0.102041
VPREB1 pre-B lymphocyte 1 0.101855
CCDC34 coiled-coil domain containing 34 0.101164
CCK cholecystokinin 0.100865
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.099857
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.099357
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.098913
ALPPL2 alkaline phosphatase, placental-like 2 0.09883
ALPP alkaline phosphatase, placental 0.098802
ALPL alkaline phosphatase, liver/bone/kidney 0.098746
ISL1 ISL LIM homeobox 1 0.098661
ZIC2 Zic family member 2 0.098348
SATB2 SATB homeobox 2 0.098348
HCRT hypocretin (orexin) neuropeptide precursor 0.09832
C2 complement component 2 0.098065
CPOX coproporphyrinogen oxidase 0.097411
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.097179
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.096976
MLN motilin 0.096657
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.09657
TNNT1 troponin T type 1 (skeletal, slow) 0.09631
INSR insulin receptor 0.096135
PTPRS protein tyrosine phosphatase, receptor type, S 0.096105
HSPG2 heparan sulfate proteoglycan 2 0.095454
PAX7 paired box 7 0.095336
MRGPRX2 MAS-related GPR, member X2 0.094411
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.094049
PGK1 phosphoglycerate kinase 1 0.093929
TCHH trichohyalin 0.093446
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.093261
NOTCH2 notch 2 0.092923
IL6 interleukin 6 0.09277
NOTCH2NL notch 2 N-terminal like 0.092708
ADCY2 adenylate cyclase 2 (brain) 0.092555
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.092524
CFD complement factor D (adipsin) 0.092493
RTN1 reticulon 1 0.089225
PRLR prolactin receptor 0.088287
IGFBP6 insulin-like growth factor binding protein 6 0.087771
ALAD aminolevulinate dehydratase 0.087738
SACS sacsin molecular chaperone 0.087606
LGI1 leucine-rich, glioma inactivated 1 0.087442
PTGDR prostaglandin D2 receptor (DP) 0.086161
NEUROD1 neuronal differentiation 1 0.08503
MMP12 matrix metallopeptidase 12 0.084763
STAT5B signal transducer and activator of transcription 5B 0.08446
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.083819
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.083751
F10 coagulation factor X 0.083549
WIPF2 WAS/WASL interacting protein family, member 2 0.083448
NPS neuropeptide S 0.083177
RAB18 RAB18, member RAS oncogene family 0.082938
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.08287
LPXN leupaxin 0.082187
CERS4 ceramide synthase 4 0.082085
PNOC prepronociceptin 0.081812
FOXH1 forkhead box H1 0.08171
PRTN3 proteinase 3 0.081364
CORT cortistatin 0.081156
APOB apolipoprotein B 0.080949
CETP cholesteryl ester transfer protein, plasma 0.080569
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.080156
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.079317
SRL sarcalumenin 0.079282
AVPR1B arginine vasopressin receptor 1B 0.078409
GCK glucokinase (hexokinase 4) 0.078374
TUBA1A tubulin, alpha 1a 0.078197
LGALS3 lectin, galactoside-binding, soluble, 3 0.077704
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.077211
GLI3 GLI family zinc finger 3 0.076538
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.076431
LPL lipoprotein lipase 0.076111
GIP gastric inhibitory polypeptide 0.07565
BMP2 bone morphogenetic protein 2 0.075366
DSC3 desmocollin 3 0.075043
AASS aminoadipate-semialdehyde synthase 0.074936
AFP alpha-fetoprotein 0.074864
SHOX short stature homeobox 0.074756