pimethixene-7468 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the pimethixene-7468 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACTL8 actin-like 8
ALDOB aldolase B, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC71 coiled-coil domain containing 71
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL6A1 collagen, type VI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHD2 EH-domain containing 2
EPOR erythropoietin receptor
ERAP1 endoplasmic reticulum aminopeptidase 1
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAM65A family with sequence similarity 65, member A
FMOD fibromodulin
GEM GTP binding protein overexpressed in skeletal muscle
GID4 GID complex subunit 4
GLRX glutaredoxin (thioltransferase)
HDAC5 histone deacetylase 5
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BO histone cluster 1, H2bo
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6R interleukin 6 receptor
INPP5K inositol polyphosphate-5-phosphatase K
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRT38 keratin 38, type I
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4 microtubule-associated protein 4
MED28 mediator complex subunit 28
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MID1 midline 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAAA N-acylethanolamine acid amidase
NIPAL2 NIPA-like domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCDHA5 protocadherin alpha 5
PDGFA platelet-derived growth factor alpha polypeptide
PLXNB1 plexin B1
POM121 POM121 transmembrane nucleoporin
PPP1R37 protein phosphatase 1, regulatory subunit 37
RAD54L2 RAD54-like 2 (S. cerevisiae)
RARB retinoic acid receptor, beta
RASAL1 RAS protein activator like 1 (GAP1 like)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF208 ring finger protein 208
RPL10L ribosomal protein L10-like
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A13 S100 calcium binding protein A13
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SGK2 serum/glucocorticoid regulated kinase 2
SH3BP2 SH3-domain binding protein 2
SH3GL3 SH3-domain GRB2-like 3
SIRT3 sirtuin 3
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC46A3 solute carrier family 46, member 3
SNTA1 syntrophin, alpha 1
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5B signal transducer and activator of transcription 5B
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TADA3 transcriptional adaptor 3
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D5 TBC1 domain family, member 5
TMCC2 transmembrane and coiled-coil domain family 2
TRIM29 tripartite motif containing 29
TUBA4B tubulin, alpha 4b
USP29 ubiquitin specific peptidase 29
VARS valyl-tRNA synthetase
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
WLS wntless Wnt ligand secretion mediator
XDH xanthine dehydrogenase
ZBTB48 zinc finger and BTB domain containing 48
ZNF362 zinc finger protein 362
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2A activin A receptor, type IIA
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ASTE1 asteroid homolog 1 (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BPHL biphenyl hydrolase-like (serine hydrolase)
C14ORF132 chromosome 14 open reading frame 132
C1ORF115 chromosome 1 open reading frame 115
C7ORF43 chromosome 7 open reading frame 43
CASZ1 castor zinc finger 1
CBR4 carbonyl reductase 4
CBX8 chromobox homolog 8
CCDC88C coiled-coil domain containing 88C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPT centromere protein T
COCH cochlin
CPOX coproporphyrinogen oxidase
CPT2 carnitine palmitoyltransferase 2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK1 dedicator of cytokinesis 1
DSCAM Down syndrome cell adhesion molecule
ERI3 ERI1 exoribonuclease family member 3
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FAM114A2 family with sequence similarity 114, member A2
FAM160B2 family with sequence similarity 160, member B2
FAN1 FANCD2/FANCI-associated nuclease 1
FUZ fuzzy planar cell polarity protein
HIST1H2AG histone cluster 1, H2ag
HIST1H4D histone cluster 1, H4d
HIST1H4J histone cluster 1, H4j
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HTRA1 HtrA serine peptidase 1
IRF6 interferon regulatory factor 6
KRT86 keratin 86, type II
LAMB2 laminin, beta 2 (laminin S)
LINC00339 long intergenic non-protein coding RNA 339
LRRC16A leucine rich repeat containing 16A
MAMLD1 mastermind-like domain containing 1
MANSC1 MANSC domain containing 1
MDM1 Mdm1 nuclear protein homolog (mouse)
METTL8 methyltransferase like 8
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTERF1 mitochondrial transcription termination factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NHLRC2 NHL repeat containing 2
NKX3-2 NK3 homeobox 2
NMU neuromedin U
NT5C 5', 3'-nucleotidase, cytosolic
PACS1 phosphofurin acidic cluster sorting protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX12 peroxisomal biogenesis factor 12
PGM1 phosphoglucomutase 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRPF39 pre-mRNA processing factor 39
PRR15L proline rich 15-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RECQL4 RecQ protein-like 4
RNF219 ring finger protein 219
RPL13P5 ribosomal protein L13 pseudogene 5
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1A SET domain containing 1A
SFT2D2 SFT2 domain containing 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNORA21 small nucleolar RNA, H/ACA box 21
SPIDR scaffolding protein involved in DNA repair
STARD13 StAR-related lipid transfer (START) domain containing 13
STK25 serine/threonine kinase 25
SUSD6 sushi domain containing 6
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TRIM25 tripartite motif containing 25
UNC13B unc-13 homolog B (C. elegans)
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
XPA xeroderma pigmentosum, complementation group A
ZBTB39 zinc finger and BTB domain containing 39
ZBTB6 zinc finger and BTB domain containing 6
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF672 zinc finger protein 672
ZNF813 zinc finger protein 813