phagocytic cup Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. (Gene Ontology, GO_0001891)
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Genes

123 proteins co-occuring with the phagocytic cup cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RASA4 RAS p21 protein activator 4 1.32817
MYO1B myosin IB 1.11735
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 1.0253
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.02281
CDC42 cell division cycle 42 0.983906
SYK spleen tyrosine kinase 0.977589
WAS Wiskott-Aldrich syndrome 0.976619
PLD2 phospholipase D2 0.920918
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.818075
VAV1 vav 1 guanine nucleotide exchange factor 0.703067
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.702626
CDC42SE2 CDC42 small effector 2 0.701304
VAMP3 vesicle-associated membrane protein 3 0.698663
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.689013
CDC42SE1 CDC42 small effector 1 0.688576
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.682027
CH25H cholesterol 25-hydroxylase 0.673762
MYO1E myosin IE 0.656033
ABR active BCR-related 0.651299
MYO1C myosin IC 0.648291
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.642286
CD300LF CD300 molecule-like family member f 0.625206
MYO1A myosin IA 0.621379
AMPH amphiphysin 0.612048
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 0.610355
RAB20 RAB20, member RAS oncogene family 0.609086
PLEK pleckstrin 0.580086
RGCC regulator of cell cycle 0.572994
TRIP10 thyroid hormone receptor interactor 10 0.565923
CLEC4E C-type lectin domain family 4, member E 0.5568
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.555559
SYT5 synaptotagmin V 0.552251
MYO10 myosin X 0.543176
ARF6 ADP-ribosylation factor 6 0.536594
OCRL oculocerebrorenal syndrome of Lowe 0.53454
DOCK1 dedicator of cytokinesis 1 0.527979
LYN LYN proto-oncogene, Src family tyrosine kinase 0.521432
BTK Bruton agammaglobulinemia tyrosine kinase 0.51164
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.510011
BAIAP2L1 BAI1-associated protein 2-like 1 0.507163
CMKLR1 chemerin chemokine-like receptor 1 0.507163
FNBP1 formin binding protein 1 0.505131
CABP1 calcium binding protein 1 0.499853
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.499447
PFN4 profilin family, member 4 0.4958
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.495395
FMN1 formin 1 0.493775
ADGRB1 adhesion G protein-coupled receptor B1 0.492561
ELMO1 engulfment and cell motility 1 0.486904
CHN1 chimerin 1 0.484079
PFN2 profilin 2 0.480855
AIF1 allograft inflammatory factor 1 0.474018
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.473215
DNM2 dynamin 2 0.472011
PFN1 profilin 1 0.462798
FMNL1 formin-like 1 0.459602
COTL1 coactosin-like F-actin binding protein 1 0.44052
DOCK2 dedicator of cytokinesis 2 0.437356
GDI1 GDP dissociation inhibitor 1 0.43538
CLEC7A C-type lectin domain family 7, member A 0.419252
CSF1 colony stimulating factor 1 (macrophage) 0.418077
HCK HCK proto-oncogene, Src family tyrosine kinase 0.41612
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.415728
SNX3 sorting nexin 3 0.40714
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.40675
DBNL drebrin-like 0.403248
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.402081
RAB21 RAB21, member RAS oncogene family 0.399751
DOCK5 dedicator of cytokinesis 5 0.383895
MFGE8 milk fat globule-EGF factor 8 protein 0.383509
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.381584
FSCN1 fascin actin-bundling protein 1 0.381584
ICAM5 intercellular adhesion molecule 5, telencephalin 0.380429
PLS1 plastin 1 0.372749
CALR calreticulin 0.35899
DIAPH1 diaphanous-related formin 1 0.358228
STX4 syntaxin 4 0.352142
DAAM1 dishevelled associated activator of morphogenesis 1 0.347967
TGM2 transglutaminase 2 0.34645
IQGAP1 IQ motif containing GTPase activating protein 1 0.343799
ARHGAP1 Rho GTPase activating protein 1 0.338128
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.333602
RAB35 RAB35, member RAS oncogene family 0.331719
ARF5 ADP-ribosylation factor 5 0.32345
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.310358
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.30626
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.296601
RALB v-ral simian leukemia viral oncogene homolog B 0.294007
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.293637
PLCD1 phospholipase C, delta 1 0.286245
FYB FYN binding protein 0.278877
NMS neuromedin S 0.277038
PI3 peptidase inhibitor 3, skin-derived 0.270068
MARCKS myristoylated alanine-rich protein kinase C substrate 0.263485
SNAP23 synaptosomal-associated protein, 23kDa 0.26166
STXBP3 syntaxin binding protein 3 0.260202
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.250026
SYT7 synaptotagmin VII 0.235966
HIP1 huntingtin interacting protein 1 0.228819
GAS6 growth arrest-specific 6 0.226686
TLN1 talin 1 0.225622
STAB2 stabilin 2 0.22279
VASP vasodilator-stimulated phosphoprotein 0.214017
CKB creatine kinase, brain 0.21228
GAB2 GRB2-associated binding protein 2 0.210894
TNF tumor necrosis factor 0.209513
ACTN1 actinin, alpha 1 0.207108
CLINT1 clathrin interactor 1 0.202009
FGR FGR proto-oncogene, Src family tyrosine kinase 0.200663
STK38 serine/threonine kinase 38 0.198991
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.195025
TYROBP TYRO protein tyrosine kinase binding protein 0.191777
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.182122
ARF1 ADP-ribosylation factor 1 0.179459
WASL Wiskott-Aldrich syndrome-like 0.177154
SIL1 SIL1 nucleotide exchange factor 0.175745
PLD1 phospholipase D1, phosphatidylcholine-specific 0.16477
TMSB4X thymosin beta 4, X-linked 0.163641
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.16233
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.16233
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.162117
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.162117
ACTN2 actinin, alpha 2 0.159658