paroxetine-3904 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the paroxetine-3904 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM2 adrenomedullin 2
AIRE autoimmune regulator
ALPK1 alpha-kinase 1
AMPD3 adenosine monophosphate deaminase 3
APOL6 apolipoprotein L, 6
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BGN biglycan
BMP5 bone morphogenetic protein 5
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C10ORF12 chromosome 10 open reading frame 12
C10ORF95 chromosome 10 open reading frame 95
C17ORF59 chromosome 17 open reading frame 59
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CD53 CD53 molecule
CDK3 cyclin-dependent kinase 3
CRAT carnitine O-acetyltransferase
CREBBP CREB binding protein
CRYM crystallin, mu
CTF1 cardiotrophin 1
CTSE cathepsin E
CXORF21 chromosome X open reading frame 21
DCBLD2 discoidin, CUB and LCCL domain containing 2
DPF1 D4, zinc and double PHD fingers family 1
DRD2 dopamine receptor D2
EDNRB endothelin receptor type B
EGR1 early growth response 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOSC1 exosome component 1
EZR ezrin
FAM182B family with sequence similarity 182, member B
FAM63B family with sequence similarity 63, member B
FCMR Fc fragment of IgM receptor
FGF6 fibroblast growth factor 6
FLT3LG fms-related tyrosine kinase 3 ligand
FRMD8 FERM domain containing 8
GGT1 gamma-glutamyltransferase 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPR25 G protein-coupled receptor 25
GPSM3 G-protein signaling modulator 3
GRIK5 glutamate receptor, ionotropic, kainate 5
HOXB9 homeobox B9
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICOS inducible T-cell co-stimulator
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA10 interferon, alpha 10
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IMPG2 interphotoreceptor matrix proteoglycan 2
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IVL involucrin
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KRT8 keratin 8, type II
LHB luteinizing hormone beta polypeptide
LOXL3 lysyl oxidase-like 3
MAGEA5 melanoma antigen family A5
MMP11 matrix metallopeptidase 11
MST1 macrophage stimulating 1
MYO1A myosin IA
NABP1 nucleic acid binding protein 1
NCOA2 nuclear receptor coactivator 2
NEFL neurofilament, light polypeptide
NNAT neuronatin
NOTCH4 notch 4
NOVA2 neuro-oncological ventral antigen 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP214 nucleoporin 214kDa
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P3H2 prolyl 3-hydroxylase 2
PDE9A phosphodiesterase 9A
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGR polymeric immunoglobulin receptor
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAUR plasminogen activator, urokinase receptor
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PQLC2 PQ loop repeat containing 2
PRX periaxin
RORC RAR-related orphan receptor C
RUSC2 RUN and SH3 domain containing 2
SASH3 SAM and SH3 domain containing 3
SAYSD1 SAYSVFN motif domain containing 1
SIRT5 sirtuin 5
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SPEG SPEG complex locus
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBXA2R thromboxane A2 receptor
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UBR2 ubiquitin protein ligase E3 component n-recognin 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
ZBED4 zinc finger, BED-type containing 4
ZC3H7B zinc finger CCCH-type containing 7B
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADCY6 adenylate cyclase 6
AGMAT agmatine ureohydrolase (agmatinase)
AMT aminomethyltransferase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BIRC7 baculoviral IAP repeat containing 7
C3 complement component 3
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC64 coiled-coil domain containing 64
CCNK cyclin K
CHKB choline kinase beta
CNGB3 cyclic nucleotide gated channel beta 3
CNR2 cannabinoid receptor 2 (macrophage)
CORO7 coronin 7
CRLF1 cytokine receptor-like factor 1
CSF1R colony stimulating factor 1 receptor
DGKE diacylglycerol kinase, epsilon 64kDa
DPY19L1P1 DPY19L1 pseudogene 1
DSCAM Down syndrome cell adhesion molecule
EMP3 epithelial membrane protein 3
ERCC2 excision repair cross-complementation group 2
ETNK2 ethanolamine kinase 2
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FMOD fibromodulin
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GEM GTP binding protein overexpressed in skeletal muscle
GPR176 G protein-coupled receptor 176
GRB7 growth factor receptor-bound protein 7
HIST1H3E histone cluster 1, H3e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC10 homeobox C10
HOXC4 homeobox C4
IL12RB1 interleukin 12 receptor, beta 1
IRF6 interferon regulatory factor 6
ITM2C integral membrane protein 2C
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLK8 kallikrein-related peptidase 8
KRT13 keratin 13, type I
LARP6 La ribonucleoprotein domain family, member 6
LIME1 Lck interacting transmembrane adaptor 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK10 mitogen-activated protein kinase 10
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBNL3 muscleblind-like splicing regulator 3
MFGE8 milk fat globule-EGF factor 8 protein
MMP17 matrix metallopeptidase 17 (membrane-inserted)
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPTX1 neuronal pentraxin I
NXPE3 neurexophilin and PC-esterase domain family, member 3
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB3 protocadherin beta 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLA2G3 phospholipase A2, group III
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCH pro-melanin-concentrating hormone
PODNL1 podocan-like 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRAMEF11 PRAME family member 11
PRSS53 protease, serine, 53
QPCT glutaminyl-peptide cyclotransferase
RAB3D RAB3D, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF170 ring finger protein 170
RPAP2 RNA polymerase II associated protein 2
RPGRIP1L RPGRIP1-like
SCARA3 scavenger receptor class A, member 3
SIRT4 sirtuin 4
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STAB2 stabilin 2
SYNC syncoilin, intermediate filament protein
TBC1D2 TBC1 domain family, member 2
TGFBR3 transforming growth factor, beta receptor III
TH tyrosine hydroxylase
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TSC22D4 TSC22 domain family, member 4
UNC93B1 unc-93 homolog B1 (C. elegans)
USP6NL USP6 N-terminal like
WNT16 wingless-type MMTV integration site family, member 16
ZNF137P zinc finger protein 137, pseudogene
ZNF34 zinc finger protein 34
ZNF492 zinc finger protein 492
ZNF623 zinc finger protein 623