paracetamol-6284 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the paracetamol-6284 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABHD2 abhydrolase domain containing 2
ADAM22 ADAM metallopeptidase domain 22
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHNAK AHNAK nucleoprotein
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AOC2 amine oxidase, copper containing 2 (retina-specific)
ATP9A ATPase, class II, type 9A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BGN biglycan
BMP7 bone morphogenetic protein 7
BTBD7 BTB (POZ) domain containing 7
CA12 carbonic anhydrase XII
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASZ1 castor zinc finger 1
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CIDEB cell death-inducing DFFA-like effector b
COL21A1 collagen, type XXI, alpha 1
CORO2B coronin, actin binding protein, 2B
CXCR2 chemokine (C-X-C motif) receptor 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCAF15 DDB1 and CUL4 associated factor 15
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMP1 dentin matrix acidic phosphoprotein 1
DOCK10 dedicator of cytokinesis 10
DRD2 dopamine receptor D2
EDN1 endothelin 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESR1 estrogen receptor 1
FABP3 fatty acid binding protein 3, muscle and heart
FAM63A family with sequence similarity 63, member A
FGFR1 fibroblast growth factor receptor 1
GPR27 G protein-coupled receptor 27
HDAC11 histone deacetylase 11
HEXA hexosaminidase A (alpha polypeptide)
HIST1H4D histone cluster 1, H4d
HLA-DOB major histocompatibility complex, class II, DO beta
HOXB5 homeobox B5
HP haptoglobin
HPS1 Hermansky-Pudlak syndrome 1
IDS iduronate 2-sulfatase
IGHD immunoglobulin heavy constant delta
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB4 integrin, beta 4
KHSRP KH-type splicing regulatory protein
KLHL28 kelch-like family member 28
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MED18 mediator complex subunit 18
MMP7 matrix metallopeptidase 7
MR1 major histocompatibility complex, class I-related
NEURL1 neuralized E3 ubiquitin protein ligase 1
NR2E1 nuclear receptor subfamily 2, group E, member 1
NTSR1 neurotensin receptor 1 (high affinity)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA5 protocadherin alpha 5
PDE4DIP phosphodiesterase 4D interacting protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PIDD1 p53-induced death domain protein 1
PLCH1 phospholipase C, eta 1
PODNL1 podocan-like 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRDX2 peroxiredoxin 2
PRSS50 protease, serine, 50
PTCH1 patched 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBBP9 retinoblastoma binding protein 9
RBM19 RNA binding motif protein 19
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC6 sialic acid binding Ig-like lectin 6
SIT1 signaling threshold regulating transmembrane adaptor 1
SIX2 SIX homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A40 solute carrier family 25, member 40
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSX3 synovial sarcoma, X breakpoint 3
STON1 stonin 1
STXBP6 syntaxin binding protein 6 (amisyn)
SUGP1 SURP and G patch domain containing 1
SYK spleen tyrosine kinase
TBX10 T-box 10
TECPR2 tectonin beta-propeller repeat containing 2
TK2 thymidine kinase 2, mitochondrial
TNNT3 troponin T type 3 (skeletal, fast)
TOM1 target of myb1 (chicken)
TSC22D4 TSC22 domain family, member 4
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
ZHX3 zinc fingers and homeoboxes 3
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ADAM15 ADAM metallopeptidase domain 15
AHDC1 AT hook, DNA binding motif, containing 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
AUH AU RNA binding protein/enoyl-CoA hydratase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BIK BCL2-interacting killer (apoptosis-inducing)
C17ORF70 chromosome 17 open reading frame 70
C1ORF159 chromosome 1 open reading frame 159
CAPN15 calpain 15
CBR4 carbonyl reductase 4
CD70 CD70 molecule
CDC45 cell division cycle 45
CDIP1 cell death-inducing p53 target 1
CHMP6 charged multivesicular body protein 6
CLK1 CDC-like kinase 1
COPS7B COP9 signalosome subunit 7B
CRYBA2 crystallin, beta A2
CSRNP3 cysteine-serine-rich nuclear protein 3
CST6 cystatin E/M
DCAF17 DDB1 and CUL4 associated factor 17
DDIT3 DNA-damage-inducible transcript 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
EFNA1 ephrin-A1
EGLN2 egl-9 family hypoxia-inducible factor 2
ELOVL4 ELOVL fatty acid elongase 4
FAM50B family with sequence similarity 50, member B
FPGS folylpolyglutamate synthase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAL3ST4 galactose-3-O-sulfotransferase 4
GCHFR GTP cyclohydrolase I feedback regulator
GJC1 gap junction protein, gamma 1, 45kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRAMD4 GRAM domain containing 4
H2AFY2 H2A histone family, member Y2
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HOXB13 homeobox B13
HYAL3 hyaluronoglucosaminidase 3
IGSF3 immunoglobulin superfamily, member 3
IREB2 iron-responsive element binding protein 2
IRF6 interferon regulatory factor 6
KATNBL1 katanin p80 subunit B-like 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0894 KIAA0894 protein
KRI1 KRI1 homolog (S. cerevisiae)
LIMS2 LIM and senescent cell antigen-like domains 2
MAST3 microtubule associated serine/threonine kinase 3
MCRS1 microspherule protein 1
MTERF1 mitochondrial transcription termination factor 1
MUC7 mucin 7, secreted
MYO1D myosin ID
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5C 5', 3'-nucleotidase, cytosolic
NUBP2 nucleotide binding protein 2
OTUD3 OTU deubiquitinase 3
PALMD palmdelphin
PIAS3 protein inhibitor of activated STAT, 3
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLEKHA6 pleckstrin homology domain containing, family A member 6
PMCH pro-melanin-concentrating hormone
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP6R2 protein phosphatase 6, regulatory subunit 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PUS1 pseudouridylate synthase 1
RASA2 RAS p21 protein activator 2
RUSC2 RUN and SH3 domain containing 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SIPA1 signal-induced proliferation-associated 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLITRK5 SLIT and NTRK-like family, member 5
SPATA2L spermatogenesis associated 2-like
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TCTN1 tectonic family member 1
TEX40 testis expressed 40
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM159 transmembrane protein 159
TMEM183A transmembrane protein 183A
TMOD3 tropomodulin 3 (ubiquitous)
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TPCN1 two pore segment channel 1
TRAPPC6A trafficking protein particle complex 6A
TTC23 tetratricopeptide repeat domain 23
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR18 WD repeat domain 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF668 zinc finger protein 668