p53 signaling pathway Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description p53 transcription factor is a tumor suppressor frequently mutated in cancer. p53 is at the hub of many signaling and regulatory pathways. In response to various stresses, it promotes apoptosis, cell cycle arrest and other defense pathways via transcription dependent as well as independent routes. A key regulator of p53 is Mdm2. Mdm2 is a transcriptional target of p53 thus providing a negative feedback loop. (Pathway Ontology, PW_0000718)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04115.html
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64 proteins participating in the p53 signaling pathway pathway from the KEGG Pathways dataset.

Symbol Name
ADGRB1 adhesion G protein-coupled receptor B1
APAF1 apoptotic peptidase activating factor 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BID BH3 interacting domain death agonist
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNB3 cyclin B3
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD82 CD82 molecule
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CYCS cytochrome c, somatic
DDB2 damage-specific DNA binding protein 2, 48kDa
EI24 etoposide induced 2.4
FAS Fas cell surface death receptor
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GTSE1 G-2 and S-phase expressed 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTEN phosphatase and tensin homolog
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SESN2 sestrin 2
SESN3 sestrin 3
SFN stratifin
SIAH1 siah E3 ubiquitin protein ligase 1
STEAP3 STEAP family member 3, metalloreductase
THBS1 thrombospondin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TP73 tumor protein p73
TSC2 tuberous sclerosis 2
ZMAT3 zinc finger, matrin-type 3